African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2221

Table of Content: October 2010; 4(10)

October 2010

Effects of intestinal trefoil factor on PI3K and caspase-3/9 in newborn rats with necrotizing enterocolitis

PI3K/Akt signal pathway was blocked by Wortmannin, a specific inhibitor of phosphoinositide-3 kinase (PI3K), and the effects of intestinal trefoil factor (ITF) on PI3K and caspase-3/9 in newborn rats with necrotizing enterocolitis (NEC) were investigated to explore the protective mechanism of ITF against NEC. Experimental NEC was induced by exposure to hypoxia for 60 sec followed by cold stress at 4°C for 10 min. A...

Author(s): Cai-Xia Yan, He-Sheng Luo, Bing-Hong Zhang, Ri-Hong Zhao and Hai-Xia Zhang

October 2010

Microencapsulation and pharmacological evaluations for the anti-fertility effect of castor bean extract in female mice

Castor Bean (Ricinus communis, Family Euphorbiaceae) ethanol extraction (CBE) possesses potent antifertility effect, but the absorption of it is limited. Therefore, this study was aimed to prepare CBE microparticles for targeted drug effect. Poly (toluene-2, 4-di-isocyanate and ethylene alcohol) (TDI-EA) microparticles loaded with CBE were prepared by Interracial polymerization, a semi-industrial technique capable of...

Author(s): Yi-ling Hou, Xiang Ding, Shuang-quan Duan, Zhi-rong Yang and Ping Gao

October 2010

Cytotoxic activity of leaf and rhizome extracts of Alpinia scabra (Blume) Náves, a wild ginger from Peninsular Malaysia

The leaves and rhizomes of Alpinia scabra (Zingiberaceae) were investigated for their cytotoxic effect against selected human cancer cell lines, namely MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line) and SKOV-3 (ovarian cancer cell line) by using an in vitro neutral red cytotoxicity assay. The methanol extracts of both leaves and rhizomes did not show active...

Author(s): H. Ibrahim, K. S. Sim, D. R. Syamsir, N. R. Mohd. Nor, A. M. Sri Nurestriand K. Awang

October 2010

Polyphenolic fractions of Algerian propolis reverses doxorubicin induced acute renal oxidative stress

The most important pharmacologically active constituents in propolis are flavanoids with a broad spectrum of biological activities varying with their chemical composition. Propolis chemical composition depends on the floral and geographical origin present at the site of collection and thus in the climatic characteristics. However, until now, no mitochondrial functions in relation to stress and apoptotic process were...

Author(s): Mesbah Lahouel, Kheira Boutabet, Wided Kebsa and Mohamed Alyane

October 2010

Recent progress in the chemo-enzymatic peptide synthesis

Peptides are molecules of paramount importance in several fields, especially in health care and nutrition. They have many beneficial health effects, such as antimicrobial, antiviral, antitumor, neuroactive and immunoactive activity. Several technologies for their production are now available such as chemical synthesis, biosynthesis and chemo-enzymatic peptide synthesis. For combining the advantages of chemical and...

Author(s): Feifei Chen, , Fangkai Zhang, , Anming Wang, Haifeng Li, Qiuyan Wang, Zhaowu Zeng, Shuling Wang and Tian Xie

October 2010

Hepatoprotective activity of Morus alba (Linn.) leaves extract against carbon tetrachloride induced hepatotoxicity in rats

The aim of the study is to investigate the hepatoprotective activity of Morus alba Linn. leaves extracts against carbon tetrachloride (CCl4) induced hepatotoxicity. Leaves powder of Morus alba was successively extracted with petroleum ether extract (PEE), chloroform extract (CHE), alcoholic extract (ALE) and water extract (AQE) against carbon tetrachloride (CCl4) induced hepatotoxicity using...

Author(s): M. G. Hogade , K. S. Patil, G. H Wadkar, S. S Mathapati and P. B Dhumal

October 2010

Effect of intra-uterine injection of H2 receptor blockers on implantation in albino Wistar rats

The role of histamine in various stages of female reproductive functions is now understood. The anti-implantation activity of various H2 receptor blockers had been established earlier by our laboratory. The present studies were conducted to evaluate the local effects of direct intra-uterine injection of H2 receptor blockers on implantation in albino Wistar rats. The individual administration of...

Author(s): Shyam S. Agrawal and Sibi P. Ittiyavirah

October 2010

Fish lipid contents and classes of selected fish species found in Lake Naivasha (Kenya) and the fish feeding habits of the lake’s inhabitants

Consumption of marine natural products including fish is very beneficial to the health and development of the human body. These natural products provide essential nutrients that are unavailable in terrestrial plants and animal natural products. Data on the levels of lipid contents, lipid classes and fatty acid composition in the total lipid of fishes found in the fresh and marine waters of Kenya have not been...

Author(s): Keriko, J. M., Chege, C. W., Magu, M. M., Mwachiro, E. C., Murigi, A. N., Githua, M. N. and Kareru, P. G.

October 2010

Protective response to Sulfadoxine-pyrimethamine during intermittent presumptive treatment of malaria in pregnant women in Sagamu, Nigeria

We study the protective response to sulfadoxine-pyrimethamine (SP) during intermittent presumptive treatment (IPT) of malaria in pregnant women. Pregnant women attending the antenatal service of the primary health centre in Sagamu, Nigeria were enrolled into the study. In addition to the usual treatment with haematinics, participants were randomized into two treatments; SP treated (SPTG) and no SP treated (NSPTG)...

Author(s): Ahmed A. Adedeji, Ernest Tambo, Fatai A. Fehintola, Mufliat Akinwunmi, Olubukola A. Tikare, Oriola I. Mebude and Olusoji E. Jagun

October 2010

Evaluation of use of antibiotic without prescription among young adults

Antibiotics are usually prescription only medicines. A high percentage of world’s antibiotics are however used in the community without prescriptions. The study evaluated use of antibiotics without prescription among young adults in Nigeria. A questionnaire was designed to assess reported purchase, name and use of antibiotic without prescription. 38.79% respondents reported purchase of an antibiotic without a...

Author(s): Oyetunde, Olubukola O., Olugbake, Olubusola A. and Famudehin, Kehinde F.