African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2284

Full Length Research Paper

A comparative study on the status of Zn and Cu in diabetic and non diabetic males in Punjab, Pakistan

Anbreen Anjum1, Muhammad Yousaf2*, Muhammad Zuber1, Tanveer Hussain Bukhari2, Ameer Fawad Zahoor2, Zafar Iqbal Khan3, Shazia Naheed2, Kulsoom Ghulam Ali2,  Bushra Purveen2, Kafeel Ahmad3, Muhammad Khalid Mukhtar3, Saira Hina4, Sajjad Ahmad5, Muhammad Umair Tariq2 and Ghulam Hussain5    
1Department of Applied Chemistry, Government College University, Faisalabad, Pakistan. 2Department of Chemistry, Government College University, Faisalabad 38040, Pakistan. 3Department of Biological Sciences, University of Sargodha, Pakistan. 4Department of Bioinformatics and Biotechnology, GC University, Faisalabad, Pakistan. 5Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.      
Email: [email protected]

  •  Accepted: 03 April 2012
  •  Published: 29 May 2012

Abstract

Minerals play a considerable role in the prolongation of all biological and psychological processes in the body. The present study was aimed to determine and to compare the concentration of zinc and copper in the serum samples of diabetic and non diabetic males of different age groups, that is, between one to seventy five years. Fasting blood samples of diabetic males as well as of non diabetics of selected age groups were collected for the study. Blood serum was obtained after centrifugation of blood samples. Level of zinc and copper in blood serum samples were determined by using atomic absorption spectrophotometer. The data obtained was processed statistically by using student’s t- test. A highly significant (p<0.01) lower levels of zinc and a highly significant (p<0.01) higher levels of copper were found in blood serum of diabetic males when they were compared with non-diabetic ones.The results reflect that the diabetic patients had a higher mean concentration of Zn (0.577 ppm), lower mean concentration of Zn (0.467 ppm), higher mean concentration of Cu (2.713 ppm) and lower mean concentration of Cu (2.207 ppm). It has also been represented by our results that the non diabetic males had higher mean concentration of Zn (1.94 ppm), lower mean concentration of Zn (0.937 ppm), higher mean concentration of Cu (1.31 ppm) and lower mean concentration of Cu (1.077 ppm). It has been concluded that the diabetic males of all age groups are deficient of zinc and they contain a higher level of copper in their blood serum.

 

Key words: Diabetic patients, minerals, blood serum, atomic absorption spectrophotometer.