African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2183

Short Communication

In vitro activity of cranberry extract against etiological agents of urinary tract infections

Mohammad Rahbar1 and Kambiz Diba2
1Department of Microbiology, Reference laboratories of Iran, Tehran, Iran. 2Department of Microbiology, Faculty of Medicine, Uremia University of Medical sciences, Uremia, Iran.
Email: [email protected]

  • Article Number - D73DE4725743
  • Vol.4(5), pp. 286-288 , May 2010
  •  Accepted: 06 April 2010
  •  Published: 31 May 2010

Abstract

Cranberries have long been the focus of interest for their beneficial effects in preventing urinary tract infections (UTIs). The objective of this study was to determine in vitro activity of cranberry extract on common etiologic agents of urinary tract infections isolated from patients. Filter sterilized methanol extract of cranberry was prepared and used in the present study. The minimum inhibitory concentration (MIC) was evaluated for active crude extract. The MIC value of methanol extract were 0.391 mg/ml for Enterobacter aerogenes andStaphylococcus aureus whereas the MIC of methanol extract of cranberry were 1.2500 and 0.0195 mg/ml for Escherichia coli and Klebsiella pneumoniae, respectively. The lower MIC value of cranberry extract against K. pneumoniae in comparison to other three organisms suggests that K. pneumoniae showed greater sensitivity towards the extracts of the cranberry extract.

 

Key words: Antibacterial activity, cranberry, urinary tract infections.