African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2199

Full Length Research Paper

In vivo analyses of the effects of co-administration of Carica papaya leaf extract with ciprofloxacin

N. O. A. Imaga1*, G. E. Ukpo2, M. A. Owolabi2, A. I. Shekoni1 and G. O. Gbenle1
1Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine of the University of Lagos, P. M. B.12003, Idi-Araba, Lagos State, Nigeria. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, CMUL Campus, Idi-Araba, Lagos State, Nigeria.
Email: [email protected], [email protected]

  •  Accepted: 14 November 2012
  •  Published: 29 December 2012

Abstract

Carica papaya leaf extract is an antisickling phytomedicine reported to inhibit the polymerisation of defective hemoglobin S molecules in sickle cell individuals. In this research, the biochemical effects of ciprofloxacin, a wide spectrum antibiotic, co-administered with C. papaya leaf extract was studied. Using standard methods for biochemical, hematological and antioxidant assays, results showed that ciprofloxacin administration gave rise to increase in oxidative stress markers, which lowered considerably during co-administration with C. papayaleaf extract, whereas administration of C. papaya leaf extract alone did not produce any of such side-effects. Co-administration of both drugs was found to have no deleterious effects on body organs and erythrocytes. This suggests that the presence of C. papaya leaf extract had a palliative effect on the free radicals produced during ciprofloxacin administration.

 

Key words:  Carica papaya, ciprofloxacin, antisickling agents, antibiotics, antioxidants.