African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 29 December, 2012; 6(48)

December 2012

In vivo analyses of the effects of co-administration of Carica papaya leaf extract with ciprofloxacin

Carica papaya leaf extract is an antisickling phytomedicine reported to inhibit the polymerisation of defective hemoglobin S molecules in sickle cell individuals. In this research, the biochemical effects of ciprofloxacin, a wide spectrum antibiotic, co-administered with C. papaya leaf extract was studied. Using standard methods for biochemical, hematological and antioxidant assays, results showed that...

Author(s): N. O. A. Imaga, G. E. Ukpo, M. A. Owolabi, A. I. Shekoni and G. O. Gbenle

December 2012

Formulation and evaluation of Cymbopogon citratus dried leaf-powder tablets

The objective of this study was to formulate Cymbopogon citratus leaves powder into tablets using both acacia and gelatin as binders at concentrations of 2, 4, 6 and 8% w/w, respectively. The tablets were evaluated using the necessary official and unofficial tests. The results showed that all the batches of tablets passed the uniformity of weight test. The hardness of the tablets was significantly affected by...

Author(s): A. Chime Salome, C. Ugwuoke Christopher Emeka, V. Onyishi Ikechukwu, A. Brown Sinye, E. Ugwu Calister and C. Onunkwo Godswill

December 2012

Effects of erythropoietin on methotrexate induced lung injury in rats

The aim of our study was to investigate the effect of erythropoietin on methotrexate induced lung injury in rats. Twenty-one female Sprague-Dawley rats were randomly assigned into 3 groups (n=7). Single-dose subcutaneous injections of 0.3 ml serum physiologic was administered to sham group, single-dose 20 mg/kg methotrexate was administered to the control group, and single-dose 20 mg/kg methotrexate and 5000 IU/kg...

Author(s): Hasan Kahraman, Vedat Bakan, Ergul Kurutas, Mahmut Tokur, Nurhan Koksal and Harun Cıralik

December 2012

Synthesis and characterization of hydrophobically modified chitosan

The aim of this paper was to prepare and evaluate the feasibility of hydrophobically modified chitosan for hemostatic use. Chitosan was grafted with different branched chains by schiff reaction with salicylaldehyde and dodecyl aldehyde and followed by reductive amination with NaBH4. Elemental analysis was carried out to calculate the degree of substitution (DS) for NH2. Fourier transform infrared spectroscopy (FTIR) and...

Author(s): Qin He, Jing Guan, Miaolei Jing, Shujie Huang, Cheng Xu, Zhihong Li, Jimin Wuand Xizheng Zhang

December 2012

Cell division inhibitor minC from Lactobacillus Acidophilus VTCC-B-871 and detection of antimicrobial activities in functional study

The minC gene of Lactobacillus acidophilus VTCC-B-871 was identified based on the genome data of L. rhamnous strains in genebank, and antimicrobial activities other than cell division inhibitor was detected. After cloning and sequencing, there was 99.1% homology betweenminC gene of L. acidophilus VTCC-B-871 and L. rhamnous GG using...

Author(s): Tu Nguyen, H. K., Vinh Doan, T. T., Ly Ha, D. and Huu Nguyen, N.

December 2012

Potentialization of antioxidant activity of Piper umbellata (Piperaceae) leaves after their metabolism in Heraclides brasiliensis larvae (Lepidoptera: Papilionidae)

Piper umbellata leaves accumulate the compound, 4-nerolidylcatechol, which is responsible for the antioxidant power of the plant. Surprisingly, in this study we observed a significant increase in the antioxidant activity of P. umbellata leaves after their metabolism on Heraclides brasiliensis larvae. The total phenolic concentrations of the extracts from the leaves and...

Author(s): Clécio S. Ramos, Andra J. L. N. Paz, Telma M. G. da Silva and Tânia M. S. da Silva

December 2012

Phytochemical analysis and antimicrobial activity of Persea duthiei

Persea duthiei plant crude extracts were subjected to evaluation for antibacterial and antifungal activities. For antibacterial activities, seven bacterial strains; Escherichia coli(NCTC 10418), Pseudomonas aeruginosa, Klebsiella pneumonia (ATCC 700603),Staphylococcus epidermidis (NCTC 11047), Staphylococcus aureus, methicillin resistant S. aureus (MRSA: NCTC 13143)...

Author(s): Shabir Ahmad, Jameel Ahmad Khader, Riaz Ullah, Naser Mohamed AbdEIslam, Salah ud Din, Rashid Khan and Shokat Mehmood

December 2012

Carnosine and cyclosporine A alleviate brain damage after traumatic brain injury in rats

The present study investigates the effects of carnosine and/or cyclosporine A (CyA) treatment against traumatic brain injury (TBI) in immature rats. Traumatized rats received carnosine [(200 mg/kg/day, in pre-and post-treatment (i.p.)] for 7 consecutive days following TBI. CyA (20 mg/kg, i.p.) was administrated 15 min and 24 h after TBI. The results revealed that TBI caused sever brain injury indicated by increased...

Author(s): L.M. Faddah, Nayira A. Abdel Baky,, Nouf M. Al-Rasheed, Azza M. Mohamed,  and Nawal M. Al-Rasheed