African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2198


Study progress of homocellular and heterocellular gap junctions in vessel wall

Yingkun He1†, Kuo Gao2†, Mingjing Zhao1*, Hong Chang1, Yonghong Gao1, Huan Lei1, Yizhou Zhao1 and Shuoren Wang1
1Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China. 2Beijing University of Chinese Medicine, Beijing 100029, China.
Email: [email protected]

  •  Accepted: 08 November 2012
  •  Published: 15 December 2012


There were four different degrees which were related to organs, tissues, cells and molecules in the study of physiopathologic process and treatment of vessel remodeling diseases. More people concentrated on the research of one kind of cell, for example, the vascular smooth muscle cell (VSMC) or adventitial fibroblast (AF) and their effect on the vessel rebuilding. However, the human body is an organic whole, so the structural and functional contacts among vascular endothelial cell, smooth muscle cell (SMC) and AF should be paid more attention to. Books and articles on the gap junction (GJ) were collected and studied. Gap junction between and among cells of the vessel wall played a critical role in many aspects of vascular function and pathology. There was homocellular communication in intima, tunicae media and adventitia singly, and also, heterocellular communication among different cells of the vessel wall. As a result, a link network was formed among cells of the vessel wall and the vessel had integrated function in the physiological and pathological process. Hence, a summary was made about the homocellular and heterocellular gap junctions, hoping that there would be more people concentrating on the whole function of vessels.


Key words: Homocellular, heterocellular, gap junctions, vessel wall.