African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2183

Full Length Research Paper

Properties of constituents from Maytenus gonoclada against Entamoeba histolytica and two leukemia cell strains

Thaisa H. S. Fonseca
  • Thaisa H. S. Fonseca
  • Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
  • Google Scholar
Fernando C. Silva
  • Fernando C. Silva
  • Departamento de Quimica,Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
  • Google Scholar
Haendel G. N. O. Busatti
  • Haendel G. N. O. Busatti
  • Universidade de Itauna, Rodovia MG 431, Km 45 (Trevo Itauna, Para de Minas), Caixa Postal 100, Itauna, CEP 35.680-142, MG, Brazil.
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Michelle O. Chacon
  • Michelle O. Chacon
  • Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
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Carla R. A. Batista
  • Carla R. A. Batista
  • Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
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Caryne M. Bertollo
  • Caryne M. Bertollo
  • Centro de Pesquisas Rene Rachou, Fiocruz, Av. Augusto de Lima, 1715. Barro Preto, Belo Horizonte, CEP 30190-002, MG, Brazil.
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Elaine M. Souza-Fagundes
  • Elaine M. Souza-Fagundes
  • Departmento de Fisiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627. Belo Horizonte. CEP 31270-901, MG, Brazil.
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Sidney A. Vieira-Filho
  • Sidney A. Vieira-Filho
  • Escola de Farmacia, Universidade Federal de Ouro Preto (UFOP), Campus Morro do Cruzeiro, s/n. 171, CEP 35400-000, Ouro Preto, MG, Brazil.
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Lucienir P. Duarte
  • Lucienir P. Duarte
  • Departamento de Quimica,Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
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Maria A. Gomes*
  • Maria A. Gomes*
  • Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 Belo Horizonte, CEP 31270-901, MG, Brazil.
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  •  Received: 18 June 2015
  •  Accepted: 01 July 2015
  •  Published: 08 August 2015

Abstract

Species of genus Maytenus represents promising sources of bioactive compounds, mainly pentacyclic triterpenes of medicinal interest. The properties of crude extracts and three known triterpenes obtained from branches and roots of Maytenus gonoclada, against Entamoeba histolytica and human promyelocytic leukemia HL-60 (myeloid leukemia), and Jurkat (lymphocytic leukemia) cells were in vitro evaluated. For crude extracts, lupeol and 3-oxo-11α-hydroxylup-20(29)-ene activity were not observed against E. histolytica, and neither against leukemic cells. Nevertheless, in relation to tingenone considerable biological effect was detected. The cytotoxic effect of tingenone was evaluated upon human peripheral blood mononuclear cells. The cytotoxic dose showed higher efficacy, compared to the other assays. The present study signalizes the importance of tingenone, as well as its use in the production of derivatives with potential antiparasitic and antitumoral properties.

Key words: Maytenus gonoclada, anti-Entamoeba histolytica activity, anti-leukemic cells activity.