African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2241

Full Length Research Paper

Prophylactic use of antibiotics for clean operative procedures

Lidao Bao1, Xianhua Ren 1, Yi Wang1 and Nan Wang2*
1Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010059, China. 2Department of Stomatolgy, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010059, China.
Email: [email protected]

  •  Accepted: 11 October 2011
  •  Published: 15 November 2011

Abstract

To present the current situation of prophylactic use of antibiotics for clean operative procedures in the department of surgery of our hospital, a total of 2000 cases with clean operative procedures were randomly selected from January 2011 to June 2011 and reviewed. Results showed all patients received prophylactic use of antibiotics (100%), which was performed at 0.5 to 2 h before surgery in 1204 cases (60.2%), at >2 h before surgery in 452 cases (22.6%), before and during surgery in 19 cases (0.95%) and after surgery in 325 cases (16.25%). Cephalosporin antibiotics were the most frequently used in 1883 cases (94.15%). Combination application of antibiotics was found in 254 cases (12.7%). The indications for prophylactic use of antibiotics in patients undergoing clean operative procedures are extensive, high-level antibiotics are used, the time of antibiotic delivery is improper and the post-operative appli-cation of antibiotics is long. Therefore, it is imperative to control the improper prophylactic application of antibiotics and develop strict principles for prophylactic application of antibiotics.

 

Key words: Rational drug use, prophylactic therapy, antibiotics, clean operative procedure.