African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2191

Full Length Research Paper

Evaluation of the antimicrobial activities of two Ziziphus species (Ziziphus mauritiana L. and Ziziphus spinachristi L.) on some microbial pathogens

M. E. Abalaka1*, S. Y. Daniyan1 and A. Mann2
1Department of microbiology, Federal University of Technology, Minna, Niger State, Nigeria. 2Department of Science Laboratory Technology, the Federal Polytechnic, Bida, Niger State, Nigeria.
Email: [email protected]

  •  Accepted: 26 January 2010
  •  Published: 30 April 2010


The antimicrobial effects Ethanolic extracts of leaves of two species of genusZiziphus were determined against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Aspergillus niger and Candida albicansS. pyogeneswas the most susceptible followed by E. coli while S. aureus was the least susceptible. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were 1 mg, 5 mg ml-1 and 20 mg, 40 mg ml-1, respectively. Extracts showed no activity against the fungal isolates - A. niger and C. albicans. The plants cannot be used in treating any type of fungal infections (dermatophycoses). The phytochemicals identified were cardiac glycosides, polyphenols, saponins and tannins. Extracts from these plants could be useful in the treatment of nosocomial infections, opportunistic infection of the unary tract (UTI), infantile gastroenteritis, travelers’ diarrhea, wound infection, meningitis, and wounds infection which are diseases caused by some of these organisms.


Key words: Antimicrobial activity, pathogenic microbes, phytochemical constituents, Ziziphus.