African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Review

Review: The potential of chalcones as a source of drugs

Rosa Martha Perez Gutierrez*
  • Rosa Martha Perez Gutierrez*
  • Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, IPN. Av. Instituto Politecnico Nacional S/N Unidad Profesional Adolfo Lopez Mateos, Col. Zacatenco, CP 07758, Mexico D.F., Mexico.
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Alethia Muniz-Ramirez
  • Alethia Muniz-Ramirez
  • Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, IPN. Av. Instituto Politecnico Nacional S/N Unidad Profesional Adolfo Lopez Mateos, Col. Zacatenco, CP 07758, Mexico D.F., Mexico.
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Jahel Valdes Sauceda
  • Jahel Valdes Sauceda
  • Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas, IPN. Av. Instituto Politecnico Nacional S/N Unidad Profesional Adolfo Lopez Mateos, Col. Zacatenco, CP 07758, Mexico D.F., Mexico.
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  •  Received: 03 January 2014
  •  Accepted: 30 January 2015
  •  Published: 28 February 2015

Abstract

Chalcone and dihydrochalcones are intermediates in the biosynthesis of flavonoids and isoflavonoids in plants. These compounds are widely investigated for their anticancer, anti-inflammatory, antimicrobial, antiprotozoal, antifilarial, larvicidal, anticonvulsant, anti-rheumatoid and antioxidant activities and their use as food additives. Chalcones are considered to be an active ingredient in a large number of medicinal herbs. Further chemical investigation of these plants has now resulted in the isolation of chalcone and biologically active derivatives. Chalcone and their derivatives are an attractive molecular scaffold for the search of new biologically active molecules. This review provides a comprehensive analysis of the source plants, chemistry, structure-activity, pharmacological reports of chalcone and derivatives isolated and identified from plants. In recent years a considerable number of investigations conducted on the biological activities of these compounds suggested a wide range of clinical applications.

Key words: Chalcones, dihydrochalcones, derivatives, bioactives, flavonoids, phytochemistry.