African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2274

Full Length Research Paper

The in vivo antihypertensive effects of standardized methanol extracts of Orthosiphon stamineus on spontaneous hypertensive rats: A preliminary study

Nurul Alia Azizan1, Rashidi Ahmad2*, Khaleed Mohamed1, Mohd Zikri Ahmad2 and Zaini Asmawi3
1Advanced Medical and Dental Institute, Bertam, Penang, Malaysia. 2School of Medical Sciences, Health Campus USM, Kelantan, Malaysia. 3School of Pharmaceuticals Sciences, Main Campus, Penang, Malaysia.
Email: [email protected]

  •  Accepted: 20 January 2012
  •  Published: 15 February 2012

Abstract

The purpose of this randomized control trial study was to investigate the effect of oralOrthosiphon stamineus (OS) on the systolic blood pressure of spontaneous hypertensive rats (SHR). The rats were divided randomly into five different groups of three rats each; group 1 received irbesartan (IR) drug (20 mg/kg) served as positive control group, group 2 received distilled water (control group) and group 3, 4 and 5 were treated with 250, 500 and 1000 mg/kg of OS extracts, respectively. Systolic blood pressure (SBP) was measured prior to and 2 weeks after intervention. There was a significant mean reduction of blood pressure among the intervention group. The efficacy of OS as antihypertensive is comparable with irbesartan 20 mg/kg.

 

Key words: Orthosiphon stamineus, systolic blood pressure, spontaneous hypertensive rats.