African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2173

Short Communication

Protective effects of Launaea procumbens against KBrO3-induced hepatic serum marker enzymes

Rahmat Ali Khan1*, Muhammad Rashid Khan2, Sumaira Sahreen2, Nasir Ali Shah2, Jasia Bokhari2, Maria Shabbir2, Umbreen Rashid2 and Shumila Jan2
1Department of Biotechnology, University of Science and Technology, KPK, Pakistan. 2Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Pakistan.
Email: [email protected]

  •  Accepted: 02 December 2011
  •  Published: 22 December 2011

Abstract

Launaea procumbens (LP) traditionally has been used in hepatic disorders. In this study, protective effects of methanol extract (LP) were evaluated in male Sprague Dawley rats biweekly for 4 weeks against KBrO3. KBrO3 induced elevation of liver serum marker enzymes (alanine transaminase (ALT), amino transaminase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)) as well as the alteration of cholesterol profile total cholesterol, triglycerides low density lipoprotein (LDL) and high density lipoprotein (HDL). The results showed that the administration of LP significantly lowered the KBrO3-induced serum level of hepatic marker enzymes (ALT, AST, ALP and LDH), total cholesterol, triglycerides low density lipoprotein (LDL) and high density lipoprotein (HDL). These results suggest that LP could protect liver against the KBrO3-induced oxidative damage in rats.

 

Key words: Launaea procumbens, amino transaminase (AST), potassium bromate (KBrO3), low density lipoprotein (LDL)-cholesterol.

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