African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2272

Full Length Research Paper

The effects of dialysers on some blood biochemical parameters in hemodialysis patients

Yazar Hayrullah1*, Balci Mehmet2, Basarali Kemal Mustafa3, Gocmen Ayse Yesim1and Buyukbas Sadik3
1Department of Biochemistry, Bozok University Medical Faculty, Yozgat, Turkey. 2Department of Infectious Diseases and Clinical Microbiology, Bozok University Medical Faculty, Yozgat, Turkey.
Email: [email protected]

  •  Accepted: 29 November 2011
  •  Published: 15 December 2011


The aim of this study is to compare some blood biochemical parameters in hemodialysis (HD) patients treated with different dialyser filters. In 70 hemodialysis patients, in six-month period, the monthly retrospective analysis of blood biochemical values has been studied. The differences in urea input/output, creatine input/output and phosphorus (P) levels were evaluated. The dialyser blood flow rate was found to be between 280 to 300 ml/min and dialysate flow rate was 500 ml/min. We found a decrease in urea and creatine levels. At the end of six-month, the most widely used dialyser was 1.5 L (50.8% of total used dialyser), followed by 1.7 L (19.4% of total use) and 1.4 L (17.4% of total use). The least used dialysers were 1.3 L (0.5% of total use used dialyser) and 1.2 L (1.3% of total use used dialyser). The average phosphorus (P) levels were different among the filters 1.4, 1.7 and 2.1 L (P < 0.05) and between 1.5 and 2.1 L (P <0.05). We found 87.6% decrease in urea and creatine, which was associated with only 3 filters (1.4, 1.5 and 1.7 L). In conclusion, the frequently used dialyser filter was1.5 L in our center, but we observed that 1.3 L was more effective in decreasing creatine and urea levels. On the other, even though we observed difference in phosphorus levels, this difference might be multifactorial and unrelated to filters used.


Key words: Dialyser filters, phosphorus, urea, creatine.