African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Review

Advances in the study of the biological function of Daxx

Jinhong Liu1*, Guozuo Xiong2, Duanfang Liao1, 3, and Qinhui Tuo1
1Learning Key Laboratory for Pharmacoproteomics, School of Life Science and Technology, University of South China, Hengyang 421001, China. 2Department of General Surgery, The Second Affiliated Hospital in University of South China, Hengyang 421001, China. 3Department of Traditional Chinese Diagnotics, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208.
Email: [email protected]

  •  Accepted: 10 March 2012
  •  Published: 22 May 2013

Abstract

Death domain-associated protein (Daxx) was originally identified as a protein that specifically binds to the death domain of the transmembrane death receptor Fas (also called CD95) in the cytoplasm and potentiates Fas-induced apoptosis. Over expression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx was found in the nuclears where it localizes to promyelocytic leukaemia (PML) oncogenic domains (PODs). As a highly conserved nuclear protein, Daxx plays an important role in proapoptosis, antiapoptosis and transcriptional regulation. This article reviews the latest advances in the study of the biological function of Daxx.

 

Key words: Death domain-associated protein (Daxx), cell apoptosis, transcriptional regulation, biological function.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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