African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2246

Full Length Research Paper

Assessment of household knowledge, attitude and practices on disposal methods of expired and unused medicines among residents of Lusaka City, Zambia

Martin Kampamba
  • Martin Kampamba
  • Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia.
  • Google Scholar
Martin Nyirenda
  • Martin Nyirenda
  • Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia.
  • Google Scholar
Hanzooma Hatwiko
  • Hanzooma Hatwiko
  • Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia.
  • Google Scholar
Davies Kampamba
  • Davies Kampamba
  • Department of Pharmacy, Women and New-born University Teaching Hospital, Zambia.
  • Google Scholar
Christabel Nangandu Hikaambo
  • Christabel Nangandu Hikaambo
  • Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia.
  • Google Scholar

  •  Received: 05 June 2020
  •  Accepted: 14 July 2020
  •  Published: 31 August 2020


Medicines play an important role in treating different diseases and conditions, but when left unused or to expire at home and improperly disposed, they may cause environmental pollution and can be hazardous to health. In this study, assessment of household knowledge attitude and practices on disposal methods of expired and unused medicines among residents was done in selected areas of Lusaka City, Zambia. This was achieved through the use of a standardized questionnaire among 385 participants. The study revealed that 94.5% of participants never received information towards safe disposal methods of expired and unused household medicines. Our study also found that 97% of participants threw away the expired drugs while 95% kept unused medicines in their homes. Only 2% and 1% of participants returned expired and unused household medicines to pharmacies respectively. In this study, there was lack of household knowledge on safe disposal methods among the majority of participants and most disposal methods used by participants are not recommended. However, participants had positive attitude towards safe disposal methods and therefore, there is need to establish state run drug take-back program of collecting unused and expired household medicines.

Key words: Disposal methods, knowledge, attitude, medicines, practices, unused, expired.



Improper disposal methods of expired and unused medicines are a global problem and occur in both developing and developed countries. In developing countries, this problem is enormous and not well documented (Atinafu et al., 2014; Hahladakis et al., 2018). Improper disposal of medicines is  associated  with environmental pollution and is a health hazard (Ajah et al., 2015; Yang et al., 2018). Improper drug disposal can lead to contamination of drinking water, development of antibiotic resistance and exposure of people to irritant or mutagenic anticancer drugs (Al-Naggar and Alareefi, 2010;  Kraemer  et  al.,  2019).   Factors   such   as   poor adherence, discontinuation of medication, adverse effects and dose changes have led to accumulation of expired and unused medicines in some households (Lystlund et al., 2014; Makki et al., 2019). A study which was conducted in Ethiopia showed that 89.1% of medicines that are procured by consumers are never used (Atinafu et al., 2014). Therefore, this may suggest that many patients and families are in possession of unused or expired medicines (Bashaar et al., 2017; Ananth et al., 2010).

Different studies conducted in different parts of the world on disposal practices for unused medicines revealed that the most popular method for household drug disposal was by trashing into the garbage (24% to 89%) or rinsing down in the toilet or sink (2 to 55%) (Atinafu et al., 2014). In a study conducted in India, most consumers stated that they dispose their medicines in the garbage and sink (Swaroop et al., 2015). In a survey conducted in the United States, more than half of the patients reported storing unused and expired medications in their homes, and of those, more than half had flushed unused and expired medicines down the toilet (Seehusen and Edwards, 2006). In Qatar, an exploratory study on medications in households conducted by Kheir and colleagues (2011) found that the majority of their study population shared prescription medications and disposed unused medicines in the garbage (Kheir et al., 2011).

In Nairobi, Kenya, a study was done on Household Knowledge and Perceptions on Disposal Practices of Unused Medicines and found that households’ knowledge on disposal practices was deficient due to lack of public outreach and awareness campaigns, negligence among healthcare professionals to provide disposal guidance at hospitals and pharmacies, unclear disposal instructions on medicine packages and negligence to read disposal instructions (Ang'ienda, 2017). Although international guidelines exist on proper disposal methods of expired and unused medicines (Abahussain and Ball, 2007), these guidelines are usually not properly enforced and very little information which is sometimes contradictory is available to the public (Peake et al., 2015; Abruquah et al., 2014).

Even though different studies have been conducted in different parts of the world to show the pattern of improper disposal of expired and unused medicines, it is not known how Lusaka residents dispose expired and unused medicine because there is currently no system that has been put in place by the regulatory authority on how to handle expired and unused medicines at household level

Furthermore there has not been any published study on assessment of household knowledge, attitude and practices on disposal methods of expired and unused medicines in Zambia. It is therefore, important to assess how expired and unused medicines are disposed of in Lusaka City.



Study design and description of study settings

This is a cross-sectional study conducted among residents of selected areas in Lusaka City from 11th June to 11th July, 2018.  The areas that were covered are low densely populated (Olympia, Woodlands) and high densely populated (Kanyama, Mtendere) which are inhabited by people from different cultural, educational and social backgrounds.

Study design

This study was undertaken through a face to face interview using structured questionnaires adopted from Ayele and Mamu (2018) to assess the knowledge, attitude and practices towards disposal of unused and expired pharmaceuticals among selected households in Lusaka City, Zambia. The questionnaire was slightly modified after pretesting to suit our setting; it comprised three parts: part I included demographic details of the study participants such as gender, age, residential area and level of education. Part II comprised questions regarding the knowledge of unused and expired drugs. In Part III, the questions were related to altitude and practices of unused and expired drug disposal.

Study population

The study population included residents of either sex (male or female) who comprised students, public and private sector employees, storekeepers and population from other walks of life regardless of ethnicity or employment status, above the age of 18 years, who were residents of Olympia, Woodlands, Kanyama and Mtendere in Lusaka, Zambia.

Sample size determination and sampling technique

The sample size was calculated using the proportion formula: n = Z²p (1-p)/e² and confidence interval level was set at 95% = 1.96. The estimated population proportion was 50% since the total population for the study areas was  unknown and margin of error was set at 5% n = (1.96)2 (0.5) (1 – 0.5) / (0.05)2 = 384.16 = 385 participants. According to Zambia Classified Urban Areas 2 (C.S.O), the approximate number of households in the following residential areas (Olympia, Woodlands, Kanyama and Mtendere) was 2240, 3614, 15084 and 11853 respectively. The approximate total number of households in all the residential areas was 32791. Therefore, the sample size was divided among the four residential areas by the use of probability-proportion to size. For Olympia, n = 2240 / 32791× 385 = 27 participants. For Woodlands, n = 3614 32791× 385 = 43 participants. For Kanyama, n = 15084 / 32791 × 385 = 178 participants. For Mtendere, n = 11853 / 32791 × 385 = 140 participants. We first randomly selected the four residential areas from the low (Olympia and woodlands) and high (Kanyama, and Mtendere) density townships around Lusaka city so that we have a sample that is well represented. We then used systemic sampling to select the households in these areas. Every fourteenth and ninth household was selected in Olympia and woodlands respectively. For Kanyama and Mtendere every second and third household was selected respectively. Only one participant from each household participated in the study.

Data processing and analysis

All  the  questionnaires  were  double-checked   for   accuracy   and sorted out manually. The raw data were then entered in Microsoft Excel spreadsheet and exported to Stata version 13 for statistical analysis. Descriptive statistics on sample characteristics was computed including median, interquartile range, frequencies and percentages. These were presented using tables and figures.

Ethical considerations

The research proposal was submitted to the University of Zambia, School of Health Sciences Research Ethics Committee in order to obtain ethical approval (Ref: 20171226145). Written and verbal consent was obtained from potential participants by explaining the objectives and anticipated benefits of the study. Their participation was on a voluntary basis and their confidentiality was assured before filling the questionnaire. No risks in participating in the study were assured to potential participants.



Social-demographic profile of participants

A total of 385 households were visited and of these households, majority were from Kanyama 175 (45.5%), followed by Mtendere 140 (36.4%), Woodlands 43 (11.1%) and Olympia 27 (7.0%) respectively. Of the participants, 344 (89.4%) were females and 41 (10.6%) were males. The median age of the participants was 30 years (IQR = 18-79). In terms of education, 99 (25.7%) of the participants attained primary education, 217 (56.4%) secondary education with 69 (17.9%) attaining tertiary education as presented in Table 1.



Participants’ knowledge on disposal methods of expired and unused medicines

As shown in Table 2, about half of the participants 200 (51.9%)  knew   about  medication  waste.  However,  the majority of participants 364 (94.5%) had never received any information about the safe and proper way to dispose medication waste. Interesting enough, a large portion of the participants 255 (66.2%) did not ever read medicines disposal instructions. Majority of the participants 212 (55.1%) responded that improper disposal of unused and expired medicines could affect the environment and health. In response on how to achieve community awareness on proper medicine waste disposal, 40.2% suggested that the media was the best source followed by doctors with 18.2% and Pharmacist with 13.0%.



Participants’ attitude on unused and expire household medicines

A total of 328 (85.2%) of the participants “strongly agreed” that children are more vulnerable to the risks associated with unused and expired household medicines. Further, 199 (51.7%) of the participants “strongly agreed” that there is no adequate information regarding the safe disposal of unused and expired household medicines hence, Pharmacists, doctors and other healthcare professionals should provide advice on safe medicine waste disposal. The majority of participants [259 (67.3%) also “strongly agreed” that take-back programs of unused and expired medicines should be introduced in communities as indicated in Table 3.



Disposal practices of unused and expired medicines among participants

100% of the participants agreed to have kept either unused or expired medicines in their homes before. When   asked   what   they   did  with  expired  medicines, majority of them [375 (97%)] stated that they threw them away while 2.8% of them returned the medicines to pharmacies. On the other hand, 364 (95%) of the participants stated that they kept the unused medicines, while 1% of them returned them to pharmacies (Table 4. Majority of the participants [232 (60.3%)] disposed their medicines in household garbage and 117 (30.4%) flushed them in toilets. The most common classes of medicines kept in households were antibiotics (55.9%) followed by analgesics (34.1%) (Figure 1). Reasons of having unused or expired medicines were mainly due to improved disease or symptoms (45.9%), followed by excess quantity supplied (29.9%) and experiencing of side effects (21.9%) (Figure 2).










This study was aimed at assessing household knowledge and attitude on disposal methods of expired and unused medicines among residents of Olympia, Woodlands, Kanyama and Mtendere in Lusaka District, Zambia. The study was cross-sectional, questionnaire-based conducted in 385 households of which majority households were from high densely populated area (Kanyama). Majority (94.5%) of the participants in this study reported that they had never received any information about the safe and proper way to dispose expired or unused medicines. The few (5.5%) participants who had received information reported obtaining such information from health professionals. This finding is consistent   with   studies  conducted  in  the  Kingdom  of Saudi Arabia (Alazmi et al., 2017), Kenya (Ang’ienda, 2017)and in Malaysia (Fatokun et al., 2011)where majority of the participants (80, 96 and 86% respectively) had never received any information on safe disposal of expired or unused medicines.

More than half of the participants (55.1%) showed correct understanding of medication waste and its effect on the environment if disposed improperly. Similarly, studies conducted in Ethiopia and India showed that 86 and 74.2% of participants respectively, understood the impact of improper disposal of households medicine on the environment  (Shivaraju et al., 2017; Ayele and Mamu,  2018).   In  this  study,  67.3%  of the participants showed willingness to use pharmacy take-back programmes of expired and unused medicines if introduced in communities. Similar study findings were obtained by Husain et al. (2017) in Pakistan, where majority (58.3%) of the medicine consumers were willing to take part in a pharmacy take-back program (Husain et al., 2017). In Jeddah and Saudi Arabia, similar results highlighting the need to establish a pharmacy take-back programme were reported (Alazmi et al., 2017). A pharmacy take-back program of expired and unused medicines if implemented would provide appropriate disposal method and may lessen likelihood of environmental pollution. A pharmacy take-back program affords communities with easy, safe, and effective means to dispose of their expired or unused medicines by taking them back to the nearest retail pharmacy or hospital (Lubick, 2010; Athern et al., 2016).

Additionally, majority (76.6%) of the participants strongly agreed that they should be more educated on the safe disposal methods of expired or unused medicines. Comparable study results were reported in India, where 77%  of the participants felt the need for more awareness among consumers regarding safe disposal methods (Sonowal et al., 2016). Further, the participants suggested that the awareness of safe medicine disposal should be mainly conducted through the media (40.2%) followed by counselling by doctors (18.2%) and pharmacists (13.0%). These results are consistent with what other studies reported in Ethiopia and Pakistan (Ayele and Mamu, 2018)and Pakistan (Husain et al., 2017).

When asked what participants did to  expired or unused medicines, 97% of the participants responded that they threw away expired medicines while 95 % reported to keep unused medicine in their homes. When asked about how the expired or unused medicines are disposed, 60.3% of the participants indicated that they mainly disposed expired or unused medicines in household garbage followed by flushing in toilets/sinks (30.4%). Comparable findings were reported in earlier studies where disposing in garbage/bin was the predominant disposal method (Swaroop et al., 2015; Annavarapu et al., 2016; Shivaraju et al., 2017)followed by disposal in the sink / toilet (Ang’ienda, 2017). Similarly, studies in Saudi Arabia showed that 79.2% of respondents disposed via household garbage/bin (Al-Shareef et al., 2016). However, different results were reported by Orina, (2018) in Nakuru town, Kenya, where the most commonly (27.3%) used method of disposal was flushing in the toilet (Orina, 2018). The differences in the findings of these studies may reflect the disparity between regulations and advice in these regions. Other countries have developed consistent programmes on safe disposal methods as well as institutional and regulatory framework that govern disposal of expired and unused medicines.

In this study, 2 and 1% of the respondents reported returning expired and unused drugs to the pharmacy respectively. This is similar to a study done in Ethiopia which reported that 2.2 and 1% of expired and unused drugs were returned to the pharmacy respectively (Ayele and Mamu, 2018). Comparable results were also found in Saudi Arabia that reported that 1.7% of respondents returned the expired and unused drugs to a pharmacy (Al-Snafi, 2017). Other studies have reported slightly high returning rate of expired or unused medicines to the pharmacy like 12.3% in Pakistan (Husain et al., 2017)and 31.3% in India (Shivaraju et al., 2017). Poor pharmacy take-back attitudes of medicines observed in our study could be attributed to lack of a policy on disposal methods of expired and unused medicines and poor/lack of dissemination of information by healthcare professionals to the public and patients in particular on how to safely dispose expired or unused medicines.

Additionally, all the participants in this study indicated keeping unused or expired medicines at home. Similar findings were reported in Pakistan by Husain et al. (2017) where more than half of the participants stored unused medications in their homes (Husain et al., 2017). In India, a similar study found that majority of the respondents stored unused medicines at home (Sonowal et al., 2016). Keeping of unused medicines in homes can lead to self-prescribing which promotes irrational medicine use. It was established that majority (45.9%) of the participants kept expired or unused medicines because they had improved symptoms, followed by having excess quantity (29.9%) and reported side effects (21.9%). Other studies have equally reported comparable reasons of keeping unused medicines (Sonowal et al., 2016; Makki et al., 2019). The results suggest a lack of adherence to medications among the majority of participants. In this regard, adequate patient counselling on adherence to medications by prescribers and pharmacists would be important. Majority (55.9%) of the participants in this study indicated disposing mainly antimicrobials followed by analgesics (34.1%).  This is comparable to a study conducted in Kenya where the most commonly (35.8%) disposed medicines among participants were antimicrobials followed by analgesics (14.4%). However, opposite results were obtained in Ethiopia (Ayele and Mamu, 2018)and Malaysia (Makki et al., 2019)where analgesics were the most disposed medicines followed by antibiotics.



This study revealed that majority of participants lacked adequate information regarding the safe disposal of unused or expired medicines.  The practice of keeping unused medicines at home and that of throwing expired medicines was very high in this study. Unsafe disposal practice of unused or expired house hold medicines was observed among the participants. However, majority of the participants requested the need of introducing state run disposal systems like drug take-back program in order to promote safe disposal of unused or expired house hold medicines within their communities.



The authors have not declared any conflict of interests.



The authors thank the University of Zambia, School of Health Sciences for supporting this study.



Abruquah A, Drewry JA, Ampratwum FD (2014). What happens to unused, expired and unwanted medications? A survey of a community-based medication disposal practices. International Journal of Development and Sustainability 3(12):2175-2185.


Ajah KC, Ademiluyi J, Nnaji CJ (2015). Engineering Spatiality, seasonality and ecological risks of heavy metals in the vicinity of a degenerate municipal central dumpsite in Enugu, Nigeria. Journal of Environmental Health Science and Engineering 13(1):15.


Al-naggar RA, Alareefi AJ (2010). Patients' opinion and practice toward unused medication disposal in Malaysia: A qualitative study. Thai Journal of Pharmaceutical Sciences 34:117-123.


Al-shareef F, El-asrar SA, Al-bakr L, Al-amro M, Alqahtani F, Aleanizy F, Al-rashood S (2016). Investigating the disposal of expired and unused medication in Riyadh, Saudi Arabia: A cross-sectional study. International Journal of Clinical Pharmacy38:822-828.


Al-snafi AE (2017). Pharmacology of Ficus religiosa-A review. 7:49-60.


Alazmi A, Alhamdan H, Abualezz R, Bahadig F, Abonofal N, Osman M (2017). Patients' Knowledge and Attitude toward the Disposal of Medications. Journal of Pharmaceutics, Article ID 8516741, 9p..


Ananth AP, Prashanthini V, Visvanathan CM (2010). Healthcare waste management in Asia. Waste Management 30:154-161.


Ang'ienda S (2017). Perceptions and Practices on Household Disposal Patterns of Unused Medicines in South C Area of Nairobi City County. University of Nairobi.


Annavarapu S, Raikar S, Patil S (2016). Knowledge, attitude and practice on safe disposal of medicines among medical and dental undergraduates. Waste Management 3:5-9.


Athern KM, Linnebur SA, Fabisiak GJTCP (2016). Proper disposal of unused household medications: The role of the pharmacist. The Consultant Pharmacist® 31:261-266.


Atinafu T, Takele A, Kassie A, Yehualaw A, Tesfaw G, Desseno T, Mekonnen T, Fentie M (2014). Unused medications disposal practice: The case of Patients visiting University of Gondar specialized teaching Hospital, Gondar, Ethiopia. International Journal of Pharmaceutical Sciences and Research 5:995-1005.


Ayele Y, Mamu M (2018). Practice Assessment of knowledge, attitude and practice towards disposal of unused and expired pharmaceuticals among community in Harar City, Eastern Ethiopia. Journal of Pharmaceutical Policy and Practice 11:27.


Bashaar M, Thawani V, Hassali MA, Saleem F (2017). Disposal practices of unused and expired pharmaceuticals among general public in Kabul. BMC Public Health17:45.


Fatokun O, Chang A, Nair T, Balakrishnan V (2011). Unused and expired medications disposal practices in the community: A cross-sectional survey in Cheras, Malaysia. Archives of Pharmacy Practice Volume 2.


Hahladakis JN, Velis CA, Weber R, Iacovidou E, Purnell P (2018). An overview of chemical additives present in plastics: migration, release, fate and environmental impact during their use, disposal and recycling. Journal of Hazardous Materials 344:179-199.


Husain T, Farooqi S, Khan M, Humayoon R, Jabeen S (2017). Medication disposal. The Professional Medical Journal 24:1380-1386.


Kheir N, El hajj M, Wilbur K, Kaissi R, Yousif A (2011). An exploratory study on medications in Qatar homes. Drug, Healthcare and Patient Safety 3:99-106.


Kraemer SA, Ramachandran A, Perron G (2019). Antibiotic pollution in the environment: from microbial ecology to public policy. Microorganisms 7:180.


Lubick N (2010). Drugs in the environment: Do pharmaceutical take- back programs make a difference? : National Institute of Environmental Health Sciences.


Lystlund S, Stevens E, Planas LG, Marcy T (2014). Patient participation in a clinic-based community pharmacy medication take-back program. Journal of the American Pharmacists Association 54:280-284.


Makki M, Hassali MA, Awaisu A, Hashmi F (2019). The Prevalence of Unused Medications in Homes. Pharmacy 7:61.


Orina CN (2018). Assessment of disposal practices of pharmaceutical waste among households within Nakuru Town, Nakuru County, Kenya. Egerton University.


Peake BM, Braund R, Tong A, Tremblay LA (2015). The Life-cycle of Pharmaceuticals in the Environment, Elsevier.


Seehusen DA, Edwards J (2006). Patient practices and beliefs concerning disposal of medications. 19:542-547.


Shivaraju PT, Gangadhar M, (2017). Knowledge and awareness of disposal of unused and expired medications among medical undergraduates of a tertiary care teaching hospital at BG Nagar: A cross-sectional observational study. National Journal of Physiology. Pharmacy and Pharmacology 7:1268-1273.


Sonowal S, Desai C, Kapadia JD, Desai MK (2016). A Survey of Knowledge, Attitude, and Practice of Consumers at a Tertiary Care Hospital Regarding the Disposal of Unused Medicines. Journal of Basic and Clinical Pharmacy 8:4.


Swaroop H, Charaborty A, Virupakshaiah A (2015). Knowledge, attitude and practice of medical professionals towards the safe disposal of unused medications in South India. World Journal of Pharmaceutical Sciences 4:1423-30.


Yang SL, Tan SL, Goh QL, Liau S (2018). Utilization of Ministry of Health medication return programme, knowledge and disposal practice of unused medication in Malaysia. Journal of Pharmacy Practice and Community Medicine 4:1-3.