African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2227

Article in Press

Synthesis, antibacterial and anticancer activities of some novel 2-substituted aminothiazoles

Thiazoles, aminothiazoles, antibacterial activity, anticancer activity.

  •  Received: 01 June 2018
  •  Accepted: 24 September 2018
Amino group of thiazole moiety (26) was treated with various aromatic aldehydes its gave corresponding Schiff's bases (27-36). These Schiff's bases were reacted with benzyl in the presence of ammonium acetate (NH4OAc) to find corresponding novel 2-substituted aminothiazoles (37-46). Structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectral data and elemental analysis. The synthesized compounds were evaluated for the antibacterial and short-term anticancer activity. All the synthesized 2-substituted aminothiazoles was shown good antibacterial activity against gram negative bacterial strain Escherichia coli. The synthesized 2-substituted aminothiazoles derivative possessed significant cytotoxic activity against Daltonꞌs Lymphoma Ascites (DLA) and Ehrlichꞌs Ascites Carcinoma (EAC) cell lines.