African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Caffeic acid reduces lipid accumulation and reactive oxygen species production in adipocytes

Mariana Brito Dantas
  • Mariana Brito Dantas
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
  • Google Scholar
Tiago Lima Sampaio
  • Tiago Lima Sampaio
  • Physiology and Pharmacology Department, Faculty of Medicine, University Federal of Ceara, Brasil.
  • Google Scholar
Ramon Róseo Paula Pessoa Bezerra de Menezes
  • Ramon Róseo Paula Pessoa Bezerra de Menezes
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
  • Google Scholar
Jamile Magalhães Ferreira
  • Jamile Magalhães Ferreira
  • University of International Integration of Afro-Brazilian Lusophony, Brazil.
  • Google Scholar
Tiago Sousa Melo
  • Tiago Sousa Melo
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
  • Google Scholar
Richard Rarison Cavalcante Meneses
  • Richard Rarison Cavalcante Meneses
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
  • Google Scholar
Hector Galdino Rodrigues
  • Hector Galdino Rodrigues
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
  • Google Scholar
Dânya Bandeira Lima
  • Dânya Bandeira Lima
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
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Alice Maria Costa Martins
  • Alice Maria Costa Martins
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
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Maria Goretti Rodrigues de Queiroz
  • Maria Goretti Rodrigues de Queiroz
  • Clinical and Toxicological Analysys Department, Faculty of Pharmacy, Odontology and Nursing, University Federal of Ceara, Brasil.
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  •  Received: 06 June 2018
  •  Published: 22 June 2018

References

Bajpai VK, Alam MB, Ju MK, Kwon KR, Huh YS, Han YK, Lee SH (2018). Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase-1 induction coupled with ERK/p38 signaling pathway. Biomedicine and Pharmacotherapy 103:1397-1407.
Crossref

 

Bocco BM, Fernandes GW, Lorena FB, Cysneiros RM, Christoffolete MA, Grecco SS, Lancellotti CL, Romoff P, Lago JH, Bianco AC, Ribeiro MO (2016). Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice. Brazilian Journal of Medical and Biological Research 49(3):3-9.
Crossref

 
 

Cho SO, Kim MH, Kim H (2018). β-Carotene Inhibits Activation of NF-κB, Activator Protein-1, and STAT3 and Regulates Abnormal Expression of Some Adipokines in 3T3-L1 Adipocytes. Journal of Cancer Prevention 23(1):37-43.
Crossref

 
 

Crevar-Sakac M, Vujić Z, Kotur-Stevuljević J, Ivanisević J, Jelić-Ivanović Z, Milenković M, Markelić M, Vujcić Z (2016). Effects of atorvastatin and artichoke leaf tincture on oxidative stress in hypercholesterolemic rats. Vojnosanitetski pregled, 73(2):178-87.

 
 

Farmer SR (2006). Transcriptional control of adipocyte formation. Cell Metabolism 4(4):263-273.
Crossref

 
 

Johnson LV, Walsh ML, Chen LB (1980). Localization of mitochondria in living cells with rhodamine 123. Proceedings of the National Academy of Sciences 77(2):990-994.
Crossref

 
 

Juman S, Yasui N, Ikeda K, Ueda A, Sakanaka M, Negishi H, Miki T (2012). Caffeic acid phenethyl ester suppresses the production of pro-inflammatory cytokines in hypertrophic adipocytes through lipopolysaccharide-stimulated macrophages. Biological and Pharmaceutical Bulletin 35(11):1941-1946.
Crossref

 
 

Kim MH, Park SJ, Kim JH, Seong JB, Kim KM, Woo HA, Lee DS (2018). Peroxiredoxin 5 regulates adipogenesis-attenuating oxidative stress in obese mouse models induced by a high-fat diet. Free Radical Biology and Medicine 123:27-38.
Crossref

 
 

Kim SH, Park HS, Hong MJ, Hur HJ, Kwon DY, Kim MS (2018). Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR-γ and Inducing Adipose Tissue Remodeling in Diet-Induced Obese Mice. Molecular Nutrition and Food Research 62(10):e1700701.
Crossref

 
 

Lin J, Della-Fera MA, Baile CA (2005). Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obesity Research 13(6):982-990.
Crossref

 
 

Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65(1-2):55-63.
Crossref

 
 

Omech B, Tshikuka JG, Mwita JC, Tsima B, Nokomazana O, Amone-P'Olak K (2016). Prevalence and determinants of metabolic syndrome: a cross-sectional survey of general medical outpatient clinics using Nattional Cholesterol Expanded Program -Adult treatment panell III criteria in Botswana. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9:1-7.
Crossref

 
 

Organization WH (2016). 'Global Health Observatory (GHO) data'. Available at: http://www.who.int/gho/en/

 
 

Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A (2016). The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. International Journal of Hepatology 4030476.
Crossref

 
 

Rondanelli M, Opizzi A, Faliva M, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E, Giacosa A (2014). Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial. Phytotherapy Research 28(1):33-41.
Crossref

 
 

Shin SH, Seo SG, Min S, Yang H, Lee E, Son JE, Kwon JY, Yue S, Chung MY, Kim KH, Cheng JX, Lee HJ, Lee KW (2014). Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage. Journal of Agricultural and Food Chemistry 62(19):4306-4312.
Crossref

 
 

Simons PJ, van den Pangaart PS, van Roomen CP, Aerts JM, Boon L (2005). Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: Evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers. Cytokine 32(2):94-103.
Crossref

 
 

Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS (2018). Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metabolism 14(4):537-44.
Crossref

 
 

Wider B, Pittler MH, Thompson-Coon J, Ernst E (2013). Artichoke leaf extract for treating hypercholesterolaemia. The Cochrane Database of Systematic Reviews 28(3):CD003335.
Crossref

 
 

Yasui N, Nishiyama E, Juman S, Negishi H, Miki T, Yamori Y, Ikeda K (2013). Caffeic acid phenethyl ester suppresses oxidative stress in 3T3-L1 adipocytes. Journal of Asian Natural Products Research 15(11):1189-1196.
Crossref

 
 

Zeng R, Fang Y, Zhang Y, Bai S (2018). p62 is linked to mitophagy in oleic acid-induced adipogenesis in human adipose-derived stromal cells. Lipids in Health and Disease 17(1):133.
Crossref

 
 

Zhou Y, Huang S, Shen H, Ma M, Zhu B, Zhang D (2016). Detection of Glutathione in Oral Squamous Cell Carcinoma Cells With a Fluorescent Probe During the Course of Oxidative Stress and Apoptosis. Journal of Oral Maxillofacial Surgery 75(1):223. 
Crossref