African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Chemotherapeutic efficacy of secnidazole-diminazene aceturate combination therapy in experimental Trypanosoma brucei brucei infection in rats

Ifeanyi G. Eke
  • Ifeanyi G. Eke
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Ikenna O. Ezeh
  • Ikenna O. Ezeh
  • Department of Veterinary Parasitology and Entomology, University of Nigeria Nsukka, Enugu State, Nigeria.
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Terry A. Ezeudu
  • Terry A. Ezeudu
  • Department of Veterinary Parasitology and Entomology, University of Nigeria Nsukka, Enugu State, Nigeria.
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Ukamaka U. Ezeh
  • Ukamaka U. Ezeh
  • Department of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Aruh O. Anaga
  • Aruh O. Anaga
  • Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria.
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Patrick A. Onyeyili
  • Patrick A. Onyeyili
  • Department of Veterinary Physiology and Pharmacology, Federal University of Agriculture, Markurdi, Benue State, Nigeria.
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  •  Received: 08 April 2017
  •  Accepted: 11 May 2017
  •  Published: 15 August 2017

References

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Gutiérrez C, González-Martín M, Corbera JA, Tejedor-Junco MT (2013). Chemotherapeutic agents against pathogenic animal Trypanosomes. Microbial pathogens and strategies for combating them: science, technology and education. Méndez-Vilas A, editor. Spain: Formatex Research Center. pp. 1564-1573.
 

Herbert WJ, Lumsden WH (1976). Trypanosome brucei: "a rapid matching method" for estimating the host's parasitemia. Exp. Parasitol. 40:427-431.
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Onyeyili PA, Anika SM (1990). Effect of combination of DL-α-difluoromethylornithine and Diminazene aceturate in Trypanosoma congolense infection in dogs. Vet. Parasitol. 37:9-19.
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Onyeyili PA, Anika SM (1991). Diminazene aceturate residues in the tissues of healthy, Trypanosoma congolense and Trypanosoma brucei brucei infected dogs. Br. Vet. J. 147:155-162.
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Onyeyili PA, Egwu GO (1995). Chemotherapy of African trypanosomiasis: A historical review. Protozool. Abstr. 5:229-243.
 

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Rickman LR, Robson J (1970). The blood incubation infectivity test: a simple test which may distinguish Trypanosoma brucei from T. rhodesiense. Bull. World Health Org. 42:650-651.
 

Schalm OW, Jain NC, Caroll EJ (1975). Veterinary haematology, 3rd edition. Hea and Febiger. Philadelphia. pp. 1919-1925.
 

Soeiro MNC, De Souza EM, Stephens CE, Boykin DW (2005). Aromatic diamidines as antiparasitic agents. Expert. Opin. Investig. Drugs 14:957-972.
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Soulsby EJL (1982). Helminthes, arthropods and protozoa of domesticated animals. 7th Edition. Bailliére Tindall, London.
 

Taiwo VO, Olaniyi MO, Ogunsanmi AO (2003). Comparative plasma biochemical changes and susceptibility of erythrocytes to in vitro peroxidation during experimental Trypanosoma congolense and T. brucei infections in sheep. Isr. J. Vet. Med. 58:435-443.

 

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