African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2278

Full Length Research Paper

Effect of grapefruit juice and sibutramine on body weight loss in obese rats

Hadir Farouk*
  • Hadir Farouk*
  • Pharmacology Department, National Research Center, Egypt.
  • Google Scholar
Sawsan S. Mahmoud
  • Sawsan S. Mahmoud
  • Pharmacology Department, National Research Center, Egypt.
  • Google Scholar
Bahia A. El-Sayeh
  • Bahia A. El-Sayeh
  • Pharmacology Department, Faculty of Pharmacy, Cairo University, Egypt.
  • Google Scholar
Ola A. Sharaf
  • Ola A. Sharaf
  • Pharmacology Department, National Research Center, Egypt.
  • Google Scholar


  •  Received: 14 September 2014
  •  Accepted: 16 February 2015
  •  Published: 28 February 2015

References

Abolfotouh MA, Soliman LA, Mansour E, Faraghaly M, El-Dawaiaty AA (2008). Central obesity among adults in Egypt: Prevalence and associated morbidity. East. Mediterr. Health J. 14.
 
Akiyamaab T, Tachibanaab I, Shiroharaab H, Watanabeab N, Otsuki M (1996). High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res. Clin. Pract. 31(1):27-35.
crossref
 
Balcioglu A, Wurtman RJ (2000). Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid. Neuropharmacology 39(12):2352-2359.
crossref
 
Barber T, Vina JR, Vina J, Cabo J (1985). Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Biochem. J. 230:675-681.
Pubmed
 
Brown M, Bing C, King P, Pickavance L, Heal D, Wilding J (2001). Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male wistar rats independently of hypothalamic neuropeptide Y. Br. J. Pharmacol. 132:1898-1904.
crossref
 
Chaw CS, Yazaki E, Evans DF (2001). The effect of pH on the gastric emptying of liquids measured by electrical impedance tomography and pH-sensitive radiotelemetry capsule. Int. J. Pharm. 227:167–175.
crossref
 
Dallas C, Gerbi A, Tenca G, Juchaux F, Bernard F (2008). Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE). Phytomedicine 15(10):783-792.
crossref
 
Estornell E, Barber T, Cabo J (1994). Improved nitrogen metabolism in rats fed on lipid-rich liquid diets. Br. J. Nutr. 71:361-373.
crossref
 
Florentin M, Liberopulos EN, Elisaf MS (2007). Sibutramine-associated adverse effects: a practical guide for its safe use. Obes. Rev. 9(4):378-387.
crossref
 
Fujioka K, Greenway F, Sheard J, Ying Y (2006). The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. J. Med. Food 9(1):49-54.
crossref
 
Gorinstein S, Caspi A, Libman I, Lerner H T, Huang D, Leontowicz H, Leontowicz M, Tashma Z, Katrich E, Feng S, Trakhtenberg S (2006). Red Grapefruit Positively Influences Serum Triglyceride Level in Patients Suffering from Coronary Atherosclerosis: Studies in Vitro and in Humans. J. Agric. Food Chem.54 (5):1887-1892.
crossref
 
Hamilton BS, Doods HN (2002). Chronic application of MTII in a rat model of obesity results in sustained weight loss. Obes. Res. 10(3):182-187.
crossref
 
Hodgson RW (1967). Horticultural varieties of Citrus. In: Reuter W, Webber HJ, Batchelor LD (eds.), The Citrus Industry. History, World Distribution, Botany and Varieties, Vol. I. University of California Press. pp. 431-591.
 
Hossain P, Kawar B, El Nahas M (2007). Obesity and Diabetes in the Developing World— A Growing Challenge. N. Engl. J. Med. 356(3):213-215.
crossref
 
Jackson HC, Bearham MC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ (1997). Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat. Br. J. Pharmacol. 121(8):1613-1618.
crossref
 
Kim SH, Lee YM, Jee SH, Nam CM (2003). Effect of Sibutramine on Weight Loss and Blood Pressure: A Meta-analysis of Controlled Trials. Obes. Res. 11:1116–1123.
crossref
 
Kim WR, Flamm SL, Di Bisceglie AM, Bodenheimer HC (2008). Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology 47(4)1363-1370.
crossref
 
Kuhlmann J, Neumann-Haefelin C, Belz U, Kramer W, Juretschke HP, Herling AW (2005). Correlation between insulin resistance and intramyocellular lipid levels in rats. Magn. Res. Med. 53(6):1275–1282.
crossref
 
Marchesini G, Centis E, Nuccitelli C (2009). The effect of life time changes in the treatment of NAFLD. Poster presentation at Liver and metabolic syndrome. Falk Liver Conference (Part II), Hannover, Germany.
 
Martire SI, Holmes N, Westbrook RF, Morris MJ (2013). Altered feeding patterns in rats exposed to a palatable cafeteria diet: increased snacking and its implications for development of obesity. PloS one 8(4):e60407.
crossref
 
Murase T, Misawa K, Haramizu S, Minegishi Y, Hase T (2010). Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK. Am. J. Physiol. Endocrinol. Metab. 299(2):E266-E275.
crossref
 
Pagel P, Blome J, Wolf HU (2000). High-performance liquid chromatographic separation and measurements of various biogenic compounds possibly involved in the pathomechanism of Parkinson's disease. J. Chromatography B. 746:297-304.
crossref
 
Paget GE, Barnes JM (1964). Evaluation of Drug Activities. In: Lawrence DR, Bacharach AL (Eds.), Pharmacometrics Vol. 1. Academic Press.
 
Pi-Sunyer FX (2002). The Obesity Epidemic: Pathophysiology and Consequences of Obesity. Obesity Res. 10(suppl.2):S97-S104.
crossref
 
Reaven GMD, Strom TK, Fox B (2002). Syndrome X: Overcoming the Silent Killer that Can Give You a Heart Attack. Published by Simon and Schuster, New York.
 
Robinson D, Whitehead TP (1989). Effect of body mass and other factors on serum liver enzyme levels in men attending for well population screening. Ann. Clin. Biochem. 26:393-400.
crossref
 
Rodríguez E, Monjo M, Rodríguez-Cuenca S, Pujol E, Amengual B, Roca P, Palou A (2001). Sexual dimorphism in the adrenergic control of rat brown adipose tissue response to overfeeding. Pflugers Arch. Eur. J. Phys. 442(3):396-403.
crossref
 
Rodríguez E, Ribot J, Rodríguez AM, Palou A (2004). PPAR- 2 Expression in Response to Cafeteria Diet: Gender- and Depot-Specific Effects. Obes. Res. 12:1455–1463.
crossref
 
Sadhu GV (2010). Process for the preparation of Caralluma extract and a formulation prepared thereof. US Patent App. 12/696,518.
 
Scora RW, Kumamot J, Soost RK, Nauer EM (1982). Contribution to the origin of the grapefruit Citrus paradisi (Rutaceae). Syst. Bot. 7(2):170-177.
crossref
 
Shela G, Hanna L, Maria L, Ryszard K, Mikolaj G, Zenon J, Yong-Seo P, Soon-Teck J, Seong-Gook K, Simon T (2007). Effect of hesperidin and naringin on the plasma lipid profile and plasma antioxidant activity in rats fed a cholesterol-containing diet. J. Sci. Food Agric. 87(7):1257-1262.
crossref
 
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, The T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (1996). Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271(2):611-614.
crossref
 
Stump AL, Mayo T, Blum A (2006). Management of grapefruit-drug interactions. Am. Fam. Physician 74(4):605-608.
Pubmed
 
Thomson DM, Porter BB, Tall JH, Kim HJ, Barrow JR, Winder WW (2007). Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. Am. J. Physiol. Endocrinol. Metab. 292(1):E196-202.
crossref
 
Yanovski SZ, Yanovski A (2002). Drug therapy: obesity. N. Engl. J. Med. 346(8):591-602.
crossref
 
Wang JB, Patterson RE, Ang A, Emond J A, Shetty N, Arab L (2014). Timing of energy intake during the day is associated with the risk of obesity in adults. J. Hum. Nutr. Diet 27(s2):255-262.
crossref
 
Wellman PJ (2000). Norepinephrine and the control of food intake. Nutrition 16(10):837-842.
crossref
 
Wilding JPH (2011). Pathophysiology and aetiology of obesity. Medicine 39(1):6-10.
crossref
 
Winder WW, Hardie DG (1999). AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am. J. Physiol. 277(1 Pt. 1):E1-10.
Pubmed
 
Winder WW, Hardie DG (1996). Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am. J. Physiol. 270(2 Pt. 1):E299-304.
Pubmed
 
World Health Organization (WHO), (2003). Obesity and overweight. Global strategy on diet, physical activity and health.
 
World Health Organization (WHO), (2010). 10 facts on obesity. Available at: http://www.who.int/features/factfiles/obesity/facts/en/index1.html.
 
World Health Organization (WHO), (2011). Obesity and overweight: fact sheet No 311. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/.