African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Formulation, optimization and characterization of candesartan cilexetil nanosuspension for in vitro dissolution enhancement

Mahesh R. Dabhi
  • Mahesh R. Dabhi
  • Department of Pharamceutical sciences, Saurashtra University, Rajkot, Gujarat, India.
  • Google Scholar
Umang K. Ghodasara
  • Umang K. Ghodasara
  • Department of Pharamceutical sciences, Saurashtra University, Rajkot, Gujarat, India.
  • Google Scholar
Dhaval D. Mori*
  • Dhaval D. Mori*
  • B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India.
  • Google Scholar
Kalpesh A. Patel
  • Kalpesh A. Patel
  • B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India.
  • Google Scholar
Ravi Manek
  • Ravi Manek
  • B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India.
  • Google Scholar
N.R. Sheth
  • N.R. Sheth
  • Smt. R.B. Patel Mahila Pharamcy College, Atkot, Gujarat, India.
  • Google Scholar


  •  Received: 17 September 2014
  •  Accepted: 22 January 2015
  •  Published: 08 February 2015

References

 

Armstrong NA, James KC (1996). Pharmaceutical Experimental Design and Interpretation, Taylor & Francis. pp.131-136
 
Chen H, Khemtong C, Yang X, Chang X, Gao J (2010). Nanonization strategies for poorly water-soluble drugs. Drug Discov. Today 16(7-8):354-360
crossref
 
Van Eerdenbrugh B, Van den Mooter G, Augustijns P (2008). Top-down production of drug nanocrystals: Nano-suspension stabilization, miniaturization and transformation into solid products. Int. J. Pharm. 364: 64-75.
crossref
 
Frömming KH, Szejtli J(1994). Cyclodextrins in Pharmacy, Springer Netherlands pp. 1-18.
crossref
 
Gassmann P, List M (1994). A Hydrosol - Alternative for parenteral application for poorly water soluble drugs. Eur. J. Biopharm. 40:64-72.
 
Matsunaga H, Eguchi T, Nishijima K, Enomoto T, Sasaoki K, Nakamura N (1999). Solid-state characterization of candesartan cilexetil (TCV-116): Crystal structure and molecular mobility. Chem. Pham. Bull. Tokyo 47:182-186.
crossref
 
Merisko-Liversidge E, Liversidge GG, Cooper ER (2003). Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur. J. Pharm. Sci. 18(2):113-120.
crossref
 
Michael Fox, Itamar Kanari, Minutza Leibovici (2008). Pharmaceutical composition comprising candesartan cilexetil Application. Available at: http://patents.justia.com/patent/20090048316
 
Müller RH, Jacobs C, Kayser O (2001). Nanosuspensions as particulate drug formulations in therapy: Rationale for development and what we can expect for the future. Adv. Drug. Deliv. Rev. 47(1):3-19.
crossref
 
Müller RH, Peters K (1998). Nanosuspensions for the formulation of poorly soluble drugs: I. Preparation by a size-reduction technique. Int. J. Pharmceut. 160(2):229-237.
crossref
 
Na GC, Stevens J, Yuan BO, Rajagopalan N (1999). Physical stability of ethyl diatrizoate nanocrystalline suspension in steam sterilization. Pharm. Res. 16(4):569-574
crossref
 
Patravale VB, Date AA, Kulkarni RM (2004). Nanosuspensions: a promising drug delivery strategy. J. Pharm. Pharmacol. 56:827-840.
crossref
 
Rabinow BE (2004). Nanosuspensions in drug delivery. Nat. Rev. Drug Discov. 3:785-796.
crossref
 
Shegokar R, Müller R (2010). Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives. Int. J. Pharm. 399:129-139.
crossref