African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2287

Full Length Research Paper

Regulation of cartilage and inflammatory biomarkers in rheumatoid arthritis patients treated with green tea therapy

Sami A. Gabr*
  • Sami A. Gabr*
  • Electron Microscope Unit, Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Google Scholar
Ahmad H. Alghadir
  • Ahmad H. Alghadir
  • Department of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, KSA.
  • Google Scholar
Gehan A. Ghoniem
  • Gehan A. Ghoniem
  • Food Industries Department, Faculty of Agriculture, Mansoura University, Mansoura, Egypt.
  • Google Scholar
Xiao-Wan Zhang
  • Xiao-Wan Zhang
  • Department of Companion and Laboratory Animal Science, Kongju National University, Daehak ro 54, Yesan-gun, Chungcheongnam-do, Korea
  • Google Scholar
Yeong-Ho Choe
  • Yeong-Ho Choe
  • Department of Companion and Laboratory Animal Science, Kongju National University, Daehak ro 54, Yesan-gun, Chungcheongnam-do, Korea
  • Google Scholar
Youn-Jin Park*
  • Youn-Jin Park*
  • Department of Companion and Laboratory Animal Science, Kongju National University, Daehak ro 54, Yesan-gun, Chungcheongnam-do, Korea
  • Google Scholar
Byeong-Soo Kim
  • Byeong-Soo Kim
  • Department of Companion and Laboratory Animal Science, Kongju National University, Daehak ro 54, Yesan-gun, Chungcheongnam-do, Korea
  • Google Scholar


  •  Received: 12 May 2013
  •  Accepted: 18 February 2014
  •  Published: 15 March 2014

References

Adcocks C, Collin P, Buttle DJ (2002). Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J. Nutr. 132:341-346.
Pubmed
 
Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE (2008). Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses trans signaling by enhancing soluble gp130 production. Proc. Natl. Acad. Sci. USA105:14692–7.
Crossref
 
Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM (2002). Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic. Biol. Med. 33:1097-1105.
Crossref
 
Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM (2004). Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and-13 in human chondrocytes. J. Pharmacol. Exp. Ther. 308:767-773.
Crossref
 
Alschuler L (1998). Green Tea: Healing tonic. Am. J. Nat. Med. 5:28-31.
 

Arab L, Il'yasova D (2003).The epidemiology of tea consumption and colorectal cancer incidence. J. Nutr. 133:S3310–8.

Pubmed

 
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF,Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr., Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315–324.
Crossref
 
Berman B (2004). Complementary and alternative medicine: is it just a case of more tools for the medical bag? Clin. J. Pain 20:1–2.
Crossref
 
Brosseau L, Wells GA, Tugwell P, Egan M, Wilson KG, Dubouloz CJ, Casimiro L, Robinson VA, McGowan J, Busch A, Poitras S, Moldofsky H, Harth M, Finestone HM, Nielson W, Haines-Wangda A, Russell-Doreleyers M, Lambert K, Marshall AD, Veilleux L; Ottawa Panel Members (2004). Ottawa panel evidence-based clinical practice guidelines for therapeutic exercises in the management of rheumatoid arthritis in adults. Phys. Ther. 84(10):934–972.
 
Chen JH, Tipoe GL, Liong EC, So HS, Leung KM, Tom WM, Fung PC, Nanji AA (2004). Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide–derived prooxidants. Am. J. Clin. Nutr. 80:742-751.
Pubmed
 
Choy EH, Panayi GS (2001). Cytokine pathways and joint infl ammation in rheumatoid arthritis. N. Engl. J. Med. 344: 907-16.
Crossref
 
Cooper R, Morre DJ, Morre DM (2005). Medicinal benefits of green tea: part I. Review of non-cancer health benefits. J. Altern. Compl. Med. 11:521-528.
Crossref
 
den Broeder AA, Joosten L, Saxne T, Heinegard D, Fenner H, Miltenburg A, Frasa W, van Tits LJ, Buurman W, van Riel PLCM, van de Putte LBA, Barrera P (2002). Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis.61:311-8.
Crossref
 
Dessein PH, Norton GR, Woodiwiss AJ, Joffe BI, Solomon A (2007). Independent role of conventional cardiovascular risk factors as predictors of C-reactive protein concentrations in rheumatoid arthritis. J. Rheumatol. 34:681–8.
Pubmed
 
Di Cesare PE, Fang C, Leslie MP, Della Valle CJ, Gold JM, Tulli H, Perris R, Carlson CS (1999). Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage. J. Orthop. Res. 17:437-445.
Crossref
 

Dingle JT (1991). Cartilage maintenance in osteoarthritis: interaction of cytokines, NSAID and prostaglandins in articular cartilage damage and repair. J. Rheumatol. 18: 30–37.

Pubmed

 
Doss MX, Potta SP, Hescheler J, Sachinidis A (2005). Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. J. Nutr. Biochem. 16:259-266.
Crossref
 
Dube B, Rita T B, Satya P, Kalra A, Michael G (2008). Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides 29: 593-598.
Crossref
 
Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J (2000). Green tea and thermogenesis: interactions between catechin polyphenols, caffeine, and sympathetic activity. Int. J. Obes. Relat. Metab. Disord. 24:252-258.
Crossref
 
Ekdahl C, Broman G (1992). Muscle strength, endurance, and aerobic capacity in rheumatoid arthritis: a comparative study with healthy subjects. Ann. Rheum. Dis. 51(1):35–40.
Crossref
 
Erba D, Riso P, Bordoni A, Foti P, Biagi PL, Testolin G (2005). Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J. Nutr. Biochem. 16:144 –9.
Crossref
 
Feldmann M, Maini SR (2008).Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol. Rev. 223:7-19.
Crossref
 
Firesten GS (2004). The T cell cometh: Interplay between adaptive immunity and cytokine networks in rheumatoid arthritis. J. Clin. Invest. 114: 471-4.
Crossref
 
Fransen J, Stucki G, Van Rielplc M (2003). Rheumatoid arthritis measures. Arthritis Rheum. 49 (Suppl.5):S214-24.
Crossref
 
Frei B, Higdon JV (2003). Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J. Nutr. 133:3275S-84S.
Pubmed
 
Graham HN (1992). Green tea composition, consumption, and polyphenol chemistry. Prev. Med. 21:334-350.
Crossref
 
Haqqi TM, Anthony DD, Gupta S, Ahmad N, Lee MS, Kumar GK, Mukhtar H (1999). Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc. Natl. Acad. Sci. USA 96:4524-4529.
Crossref
 
Hitchon CA, Alex P, Erdile LB, Frank MB, Dozmorov I, Tang Y, Wong K, Centola M, El-Gabalawy HS (2004). A distinct multi-cytokine profi le is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis. J. Rheumatol. 31:2336-46.
Pubmed
 
Hoff JF, Singlengleton KIA (1997). A method for determination of tannin in foods by means of immobilized enzymes. J. Food Sci. 42:1566.
Crossref
 
Hye SP, Jung YP, Rina Y (2005). Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res. Clin. Pract. 69:29-35.
Crossref
 
Inoue E, Yamanaka H, Hara M, Tomatsu T, Kamatani N (2007). Comparison of Disease Activity Score (DAS)-28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values. Ann. Rheum. Dis. 66:407–409.
Crossref  
 
Juhel C, Armand M, Pafumi Y, Rosier C, Vandermander J, Lairon D (2000). Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J. Nutr. Biochem. 11:45-51.
Crossref
 
Khokhar S, Magnusdottir SGM (2002). Total phenol, catechin and caffeine contents of teas commonly consumed in the United Kingdom. J. Agric. Food Chem. 50:565.
Crossref
 
Kim S, Lee MJ, Hong J, Li C, Smith TJ, Yang GY, Seril DN, Yang CS (2000). Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols. Nutr. Cancer 37:41-48.
Crossre
 
Kremers HM, Nicola P, Crowson CS, Michael O' fallon W, Gabriel SE (2004). Therapeutic strategies in rheumatoid arthritis over a 40-year period. J. Rheumatol. 31:2366–2373.
Pubmed
 
Kroot EJ1, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van't Hof M, van de Putte LB, van Rijswijk MH, van Venrooij WJ, van Riel PL (2000). The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 43:1831-1835.
Crossref
 
Lambert JD, Sang S, Yang CS (2007). Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol. Pharm. 4:819–25.
Crossref
 
Lin RW, Chen CH, Wang YH, Ho ML, Hung SH, Chen IS, Wang GJ (2009). (–)-Epigallocatechin gallate inhibition of osteoclastic diff erentiation via NF-κB. Biochem. Biophys. Res. Commun. 379:1033-1037.
Crossref
 
Lin SK, Chang HH, Chen YJ, Wang CC, Galson DL, Hong CY, Kok SH (2008). Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/ Raf-1 interaction: a potential therapeutic benefit for arthritis. Arthritis Rheum. 58:3145-3156.
Crossref
 
Lipsky PE (2005). Rheumatoid arthritis. In: Kasper D, Braunwald E, Fauci A, Hauser S, Longo D, Jameson J (eds.), Harrison's principles of internal medicine, 16th ed. New York: McGraw-Hill.
 
Majeed M, McQueen F, Yeoman S, McLean L (2004).Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis. Ann. Rheum. Dis. 63:1166-1168 doi:10.1136/ard.2003.010942
Crossref
 
Maki KC, Reeves MS, Farmer M, Yasunaga K, Matsuo N, Katsuragi Y, Komikado M, Tokimitsu I, Wilder D, Jones F, Blumberg JB, Cartwright Y (2009). Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J. Nutr. 139:264-270.
Crossref
 
Malemud CJ (2004). Cytokines as therapeutic targets for osteoarthritis. Biol. Drugs 18:23-35.
Crossref
 
Malemud CJ (2006). Matrix metalloproteinases: role in skeletal development and growth plate disorders. Front. Biosci. 11:1702-15.
Crossref
 
Manning J, Roberts JC (2003). Analysis of catechin content of commercial green tea products. J. Herbal Pharmacother. 3:19-32.
Crossref
 
Månsson B, Carey D, Alini M, Ionescu M, Rosenberg LC, Poole AR, Heinegård D, Saxne T (1995).Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J. Clin. Invest. 95:1071-7.
Crossref
 
McInnes IB (2001). Rheumatoid arthritis: From bench to bedside. Rheum. Dis. Clinics North Am. 27(2):373–387.
Crossref
 

McKenna DJ, Hughes K, Jones K (2000). Green tea monograph. Altern. Ther. Health Med. 6:61–8, 70–2, 4.

Pubmed

 
Morinobu A, Biao W, Tanaka S, Horiuchi M, Jun L, Tsuji G, Sakai Y, Kurosaka M, Kumagai S (2008). (–)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice. Arthritis Rheum. 58:2012-2018.
Crossref
 
Morozzi G, Fabbroni M, Bellisai F, Cucini S, Simpatico A, Galeazzi M (2007). Low serum level of COMP, a cartilage turnover marker, predicts rapid and high ACR70 response to adalimumab therapy in rheumatoid arthritis. Clin. Rheumatol. 26:1335–1338.
Crossref
 
Mundermann A, Dyrby CO, Andriacchi TP, King KB (2005). Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults. Osteoarthritis Cartilage 13:34–38.
Crossref
 
Natsume H, Adachi S, Takai S, Tokuda H, Matsushima-Nishiwaki R, Minamitani C, Yamauchi J, Kato K, Mizutani J, Kozawa O, Otsuka T (2009). (–)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts. Int. J. Mol. Med. 24:197-203.
Pubmed
 
Niki Y, Takeuchi T, Nakayama M, Nagasawa H, Kurasawa T, Yamada H, Toyama Y, Miyamoto T (2012). Clinical Significance of Cartilage Biomarkers for Monitoring Structural Joint Damage in Rheumatoid Arthritis Patients Treated with Anti-TNF Therapy. PLoS ONE 7(5):e37447.
Crossref
Nutrition and Your Health: Dietary Guidelines for Americans (1995). U.S. Department of Agriculture, U.S. Department of Health and Human Services. 4th edition.
 
Ohinishi M, Morishita H, Iwahashi H, Shizuo T, Yoshiaki S, Kimura M, Kido R (1994). Inhibitory effects of chologenic acids on linoleic acid peroxidation and haemolysis. Phytochemistry 36:579-583.
Crossref
 
Patrick B, Tobias B, Ru¨diger H, Georg B, Roland J, Felix B, Michael S, Heike N (2010). Dietinduced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats. Endocrinology 38:104–112.
 
Pope RM (2002). Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat. Rev. Immunol. 2:527-535.
Crossref
 
Ramesh E, Geraldine P, Thomas PA (2009). Regulatory effect of epigallocatchin gallate on the expression of C-reactive protein and other inflammatory markers in an experimental model of atherosclerosis. Chem. Biol. Interact. [Epub ahead of print].
 
Ravishankara M N, Shrivastava N, Padh H, Rajani M (2002). Evaluation of antioxidant properties of root bark of Hemidesmus indicus R. Br. (Anantmul). Phytomedicine 9:153-160.
Crossref
 

Riegsecker S, Wiczynski D, Kaplan MJ, Ahmed S (2013). Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis. Life Sci. 3;93(8):307-12.

Pubmed

 
Sabu MC, Priya TT, Ramadsan K, Ikuo Nishigaki1 I (2010). Beneficial effect of green tea; A literature review. Chin. Med 5:13.
Crossref
 
Sattar N, McCarey DW, Capell H, McInnes IB (2003). Explaining how "high-grade "systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108(24):2957–2963.
Crossref
 
Saxne T, Månsson B (2000). Molecular markers for assessment of cartilage damage in rheumatoid arthritis. In: Firestein G, Panayi GS, Wollheim FA (eds.), Rheumatoid Arthritis: New Frontiers in Pathogenesis and Treatment. Oxford: Oxford University Press. pp. 291-304.
 
Singh R, Ahmed S, Islam N, Victor M. Goldberg VM, Haqqi TM (2002). Epigallocatechin-3- gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor κB. Arthritis Rheum. 46:2079-2086.
Crossref
 
Skoumal M, Haberhauer G, Feyertag J, Kittl EM, Bauer K, Dunky A (2004). Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome. Arthritis Res. Ther. 6:73-74.
Crossref
 
Skoumal M, Kolarz G, Klingler A (2003). Serum levels of cartilage oligomeric matrix protein. A predicting factor and a valuable parameter for disease management in rheumatoid arthritis. Scand. J. Rheumatol. 32:156-61.
Crossref
 
Smith JB, Haynes MK (2002). Rheumatoid arthritis; a molecular understanding. Ann. Intern. Med. 136:908-22.
Crossref
 
Smolen JS, Breedveld FC, Schiff MH, Kalden JR, Emery P, Eberl, G, van Riel PL, Tugwell P (2003). A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology 42:244–57.
Crossref
 
Sokka T, Häkkinen A, Kautiainen H, Maillefert JF, Toloza S, Mørk Hansen T, Calvo-Alen J, Oding R, Liveborn M, Huisman M, Alten R, Pohl C, Cutolo M, Immonen K, Woolf A, Murphy E, Sheehy C, Quirke E, Celik S, Yazici Y, Tlustochowicz W, Kapolka D, Skakic V, Rojkovich B, Müller R, Stropuviene S, Andersone D, Drosos AA, Lazovskis J, Pincus T; QUEST-RA Group (2008). Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study. Arthritis Rheum. 59:42–50.
Crossref
 
Takai S, Matsushima-N R, Adachi S, Natsume IH, Minamitani C, Mizutani J, Otsuka T, Tokuda H, Kozawa O (2008). (–)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK. Mediators Inflamm. 2008: 291808.
Crossref
 
Takeuchi T, Yamanaka H, Inoue E, Nagasawa H, Nawata M, Ikari K, Saito K, Sekiguchi N, Sato E, Kameda H, Iwata S, Mochizuki T, Amano K, Tanaka Y (2008). Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one year outcome of joint destruction (RECONFIRM-2J). Mod Rheumatol. 18:447–454.
Crossref
 
Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ (2003). Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. Eur. J. Biochem. 270:2394-2403.
Crossref
 
Wahyudi S, Sargowo D (2007). Green tea polyphenols inhibits oxidized LDL- induced NKKB activation in human umbilical vein endothelial cell. Acta Med. Indones. 39(2): 66-70.
Pubmed
 
Waskmundzka M, Wianowska D, Szewczyk K, Oniszczuk A (2007). Effect of sample-preparation methods on the HPLC quantitation of some phenolic acids in plant materials. Acta Chromatographica 19:227-237.
 
Yang MH, Wang CH, Chen HL (2001). Green tea, Oolong and black tea extract modulate lipid metabolism in hyper lipidemic rats fed high sucrose diet. J. Nutr. Biochem. 12:14-20.
Crossref
 
Yen GC, Chen HY (1997). Antioxidant activity of various tea extracts in relation to their mutagenicity. J. Agric. Food Chem. 43:27.
Crossref
 
Yokozawa T, Dong E, Nakagawa T, Kashiwagi H, Nakagawa H, Takeuchi S, Chung HY (1998). In vitro and in vivo studies on the radical-scavenging activity of tea. J. Agric. Food Chem. 46:2143.
Crossref
 
Young-Min S, Cawston T, Marshall N, CoadyD, Christgau S, Saxne T, Robins S, Griffiths I (2007). Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers. Arthritis Rheum. 56:3236–3247.
Crossref