African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Full Length Research Paper

Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase

Oluoch Linus Lincone
  • Oluoch Linus Lincone
  • Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi. P. O. Box 30197–00100, Nairobi, Kenya.
  • Google Scholar
Mbugua Paul Mungai
  • Mbugua Paul Mungai
  • Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi. P. O. Box 30197–00100, Nairobi, Kenya.
  • Google Scholar
Muriithi Anne Wangechi
  • Muriithi Anne Wangechi
  • Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi. P. O. Box 30197–00100, Nairobi, Kenya.
  • Google Scholar
Siringo Cyril George
  • Siringo Cyril George
  • Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi. P. O. Box 30197–00100, Nairobi, Kenya.
  • Google Scholar
Wafula David Kayaja
  • Wafula David Kayaja
  • Department of Medical Physiology, School of Medicine, College of Health Sciences, University of Nairobi. P. O. Box 30197–00100, Nairobi, Kenya.
  • Google Scholar
Boniface Mwangi Chege
  • Boniface Mwangi Chege
  • Department of Medical Physiology, School of Health sciences, Dedan Kimathi University of Technology, P. O. Box 657-10100, Nyeri, Kenya.
  • Google Scholar


  •  Received: 05 April 2019
  •  Accepted: 06 May 2019
  •  Published: 08 June 2019

References

Alkizim FO, Matheka D, Abdulrahman FK, Muriithi A (2012). Inhibitory effect of Mangifera indica on gastrointestinal motility. Medicinal Chemistry and Drug Discovery 2(1):9-16

 

Annaházi A, Róka R, Rosztóczy A, Wittmann T (2014). Role of antispasmodics in the treatment of irritable bowel syndrome. World Journal of Gastroenterology 20(20):6031.
Crossref

 

Aslam N, Janbaz KH (2017). Antispasmodic and bronchorelaxant activities of Salsola imbricata are mediated through dual Ca+2 antagonistic and β-adrenergic agonistic effects. Pharmaceutical Biology 55(1):1131-1137. 
Crossref

 

Cavalcante-Silva LHA, Correia AC, de C, Sousa JCF, Barbosa-Filho JM, Santos BV, de O, de Miranda GEC, Alexandre-Moreira MS, Cavalcante F, de A (2016). Involvement of β adrenergic receptors in spasmolytic effect of caulerpine on guinea pig ileum. Natural Product Research 30(22):2605-2610.
Crossref

 

Chda A, El Kabbaoui M, Chokri A, El Abida K, Tazi A, Cheikh RB (2016). Spasmolytic Action of Centaurium erythraea on Rabbit Jejunum is through Calcium Channel Blockade and NO Release. European Journal of Medicinal Plants 11(2):1-13.
Crossref

 

Cortés AR, Delgadillo AJ, Hurtado M, Domínguez-Ramírez AM, Medina JR, Aoki K (2006) . The antispasmodic activity of Buddleja scordioides and Buddleja perfoliata on isolated intestinal preparations. Biological and Pharmaceutical Bulletin 29(6):1186-1190.
Crossref

 

Devi RC, Sim SM, Ismail R (2011). Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum. Journal of Smooth Muscle Research 47(5):143-156.
Crossref

 

Field M (2003). Intestinal ion transport and the pathophysiology of diarrhea. The Journal of Clinical Investigation 111(7):931-943 
Crossref

 

Geissler PW, Harris SA, Prince RJ, Olsen A, Odhiambo RA, Oketch-Rabah H, Madiega PA, Andersen A, Mølgaard P (2002). Medicinal plants used by Luo mothers and children in Bondo district Kenya. Journal of Ethnopharmacology 83(2):39-54. 
Crossref

 

Grasa L, Rebollar E, Arruebo M, Plaza M, Murillo M (2005). The role of NO in the contactility of rabbit small. Journal of Physiology and Pharmacology 56(3):407-419

 

Groneberg D, König P, Koesling D, Friebe A (2011). Nitric Oxide-Sensitive Guanylyl Cyclase Is Dispensable for Nitrergic Signaling and Gut Motility in Mouse Intestinal Smooth Muscle. Gastroenterology 140:1608-1617.
Crossref

 

Kaplan GG (2015). The global burden of IBD: from 2015 to 2025. Nature Reviews Gastroenterology and Hepatology 12(12):720. 
Crossref

 

Khan T, Ali S, Qayyum R, Hussain I, Wahid F, Shah AJ (2016). Intestinal and vascular smooth muscle relaxant effect of Viscum album explains its medicinal use in hyperactive gut disorders and hypertension. BMC Complementary and Alternative Medicine 16(1):251. 
Crossref

 

Kigen G, Some F, Kibosia J (2014). Ethnomedicinal plants traditionally used by the keiyo community in Elgeyo Marakwet County, Kenya.

 

Kinuthia DG, Muriithi AW, Mwangi PW (2016). Freeze dried extracts of Bidens biternata (Lour.) Merr. and Sheriff. show significant antidiarrheal activity in in-vivo models of diarrhea. Journal of Ethnopharmacology 193:416-422.
Crossref

 

Kito Y, Mitsui R, Ward SM, Sanders KM (2015). Characterization of slow waves generated by myenteric interstitial cells of Cajal of the rabbit small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology 308(5):378-388.
Crossref

 

Naseri MG, Heidari A (2007). Antispasmodic effect of Anethum graveolens fruit extract on rat ileum. International Journal of Pharmacology 3(3):260-264.
Crossref

 

Ondicho J, Ochora J, Matu E, Mutai J (2016). Factors associated with use of herbal medicine among patients in herbal clinics in Gucha district, Kenya, in: Scientific Conference Proceedings.

 

Ragy M, Elbassuoni E (2012). The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro. Journal of Physiology and Biochemistry 68(4):521-528.
Crossref

 

Sanders KM, Koh SD, Ro S, Ward SM (2012). Regulation of gastrointestinal motility-insights from smooth muscle biology. Nature Reviews Gastroenterology and Hepatology 9(11):633
Crossref

 

Sanders KM, Ward SM (2019). Nitric oxide and its role as a non‐adrenergic, non‐cholinergic inhibitory neurotransmitter in the gastrointestinal tract. British Journal of Pharmacology 176(2):212-227.
Crossref

 

Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE (2013). Global burden of childhood pneumonia and diarrhoea. The Lancet 381(9875):1405-1416. 
Crossref

 

Yazdi H, Seifi A, Changizi S, Khori V, Hossini F, Davarian A, Enayati JY, Mazandarani A, Nanvabashi MF (2017). Hydro-alcoholic extract of Matricaria recutita exhibited dual anti-spasmodic effect via modulation of Ca2+ channels, NO and PKA2-kinase pathway in rabbit jejunum. Avicenna Journal of Phytomedicine 7(4):334.