African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Determination of the abortifacient activity of the aqueous extract of Phytolacca dodecandra (L’Her) leaf in Wistar rats

Angella Namulindwa
  • Angella Namulindwa
  • Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda.
  • Google Scholar
David Nkwangu
  • David Nkwangu
  • Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, P. O. Box 1410, Mbarara, Uganda.
  • Google Scholar
Joseph Oloro*
  • Joseph Oloro*
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Mbarara University of Science & Technology, P. O. Box 1410, Mbarara, Uganda.
  • Google Scholar


  •  Received: 11 November 2014
  •  Accepted: 21 January 2015
  •  Published: 22 January 2015

References

 

Anees AS, Mohammed A (2004). Practical pharmaceutical chemistry, 1st edn, Faculty of Pharmacy Hamdard University, New Dehli, pp 125-132.
 
Bhargava SK (1986). Estrogenic and postcoital anticonceptive activity in rats of Butin isolated from Butea monosperma seed. J. Ethnopharmacol. 18:95-101
crossref
 
Cassarett L, Doull J (2008). The Basic Science of Poisons, 7th ed, New York, McGraw Hill publishers. p 1454.
 
Dabhadkar D, Zade V (2013). Abortifacient efficacy of Indigofera trifoliata leaves extract on female albino rats. Asian J. Pharm. Clin. Res. 6(suppl. 3):75-79.
 
Elderfied RC (1980). Biographical memoir for Walter Abraham Jacobs, 51. National Academy of sciences, Washington (DC). pp 247-278.
 
Gandhi M, Lal R, Sankaranarayanan A, Sharma PL (1991). Post-coital antifertility activity of Ruta graveolens in female rats and hamsters. J. Ethnopharmacol. 348:49-59.
crossref
 
Goonasekera MM, Gunawardana VK, Jayasena K, Mohammed SG, Balasubramaniam S (1995). Pregnancy terminating effect of Jatropha curcas in rats. J. Ethnopharmacol.47:117-123.
crossref
 
Grimes DA, Benson J, Singh S, Romeo M, Ganatra B, Okonofua FE, Shah IH (2006). Unsafe abortion: The preventable pandemic. Lancet 368:1908-1919.
crossref
 
Hiremath SP, Hanumantharao S (1990). Antifertility efficacy of the plant Striga lutea (scrophulariaceae) on rats. Contraception 42:466-477.
crossref
 
Kamatenesi M, Oryem O, Olwa O, Makawiti W (2006). Ethno-pharmacological screening of Vernonia amygdalina and Cleome gynandra traditionally used in child birth in Western Uganda, NAPRECA Symposium Book of Proceedings, Madagascar. pp 110-122.
 
Katende AB, Birnie A, Tengnas B (1995). Useful trees and shrubs for Uganda: Identification, propagation and management for agricultural and live stock communities, Technical Hand book no.10. Regional Soil Conservation Unit. Nairobi, Kenya p 710.
 
Kazerooni T, Mousavizadeh K, Abdollahee A, Sarkarian M, Sattar A (2006). Abortifacient effect of Prangos ferulacia on pregnant rats. Contraception 73(5):554-556
crossref
 
Khanna U, Chaudhury RR (1968). Antifertility screening of plants part I Investigation on Butea monosperma Linn. Indian J. Med. Res. 56: 1574-1579.
 
Koneri R, Saraswayi CD, Balaraman R, Ajeesha E (2007). Antiimplantation activity of the Ethanolic Root extract of Momordicacymbalariafenzl in rats. India J. Pharmacol. (39)2:90-96.
crossref
 
Kress H (2013). Herbal abortives and birth control. Availabe at: http://www.henriettesherbal.com.
 
Lorke D (1983). A new approach to acute toxicity testing: Arch. Toxicol. 54:275-287.
crossref
 
Lutoti S, Iberet J, Kwiringira W, Kazibwe G (2013). Toxicological review of herbal medicinal products on the Ugandan market. Afr. J. Pharm. Sci. Pharm. 4(1).
 
Nalule AS, Mbaria JM, Olila D, Kimenju JW (2011). Ethnopharmacology practices in management of livestock helminthes by pastoral communities in the dry lands of Uganda. Livestock Res. Rural Dev. 23(2):36
 
Ogutu AL, Lilechi DB, Mutai C, Bii C (2012). Phytochemical analysis and antimicrobial activity of Phytolacca dodecandra, Cucumisacculeatus and Erytrinexcelsa. Int. J. Biol. Chem. Sci. 6(2):692-704.
 
Prada E, Florence M, Fatima H. A, Rose N, Charles K (2005). Abortion and Post abortion Care In Uganda: A Report from Health Care Professionals and Health Facilities, Occasional report, New York: The Alan Guttmacher Institute. No. 17. Available at: http://www.guttmacher.org/pubs/2005/05/28/or17.pdf
 
Ritchie HE (2001). The safety of herbal medicine used during pregnancy. Front. Fetal Health 3(10):259-266.
 
Saraiya M, Berg CJ, Kendrick JS, Strauss LT, Atrash HK, Ahn YW (1998). Cigarette smoking as a risk factor for ectopic pregnancy. Am. J. Obstet. Gynecol. 178(3):493-8.
crossref
 
Selin H (1997). Encyclopedia of the history of science, technology and medicine in non-Western cultures, Dordrecht; Boston: Kluwer Academic.
crossref
 
Stella OOD, Grace EU, Herbert ABC, Samuel AD (2009). Oxytocic and anti-implantation activities of the leaf extract of Graptophyllum pictum. Afr. J. Biotechnol. 8:21. view
 
Wang JY, Ruan Al (1996). Triterpenes of Marsdenia globifera (for antifertility), Chin. Pharm. J. 31:266-269.
 
Yakubu MT, Bukoye BB (2009). Abortifacient potentials of the aqueous extract of Bambusa vulgaris leaves in pregnantc Dutch rabbits. Contraception 80(3):308-13.
crossref
 
Yeung HW, Feng Z, Li WW, Cheing WK (1987). Abortifacient activity in leaves, roots and seeds of Phytolacca acinosa. J. Ethnopharmacol. 21:31-35.
crossref
 
Zimudzi C (2007). Adenia lobata (Jacq.) Engl. In: Schmelzer, G.H. & Gurib-Fakim, A. (ed). Prota 11(1): Medicinal plants/Plantes médicinales 1. [CD-Rom]. PROTA, Wageningen, Netherlands.