African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Effo Kouakou Etienne
  • Effo Kouakou Etienne
  • Département de Pharmacologie, Pharmacie clinique et Thérapeutique, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire.
  • Google Scholar
Kouakou Sylvain Landry
  • Kouakou Sylvain Landry
  • Département de Pharmacologie, Pharmacie clinique et Thérapeutique, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire.
  • Google Scholar
Irie-N’Guessan Amenan Genevieve
  • Irie-N’Guessan Amenan Genevieve
  • Département de Pharmacologie, Pharmacie clinique et Thérapeutique, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire.
  • Google Scholar
Akoubet Aminata
  • Akoubet Aminata
  • Département de Pharmacognosie, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire.
  • Google Scholar
Kouakou-Siransy N’Doua Gisèle
  • Kouakou-Siransy N’Doua Gisèle
  • Département de Pharmacologie, Pharmacie clinique et Thérapeutique, UFR Sciences Pharmaceutiques et Biologiques, Université Félix Houphouet Boigny, Abidjan, Côte d’Ivoire.
  • Google Scholar


  •  Received: 24 August 2017
  •  Accepted: 21 September 2017
  •  Published: 22 October 2017

References

Ajibade TO, Olayemi FO (2015). Reproductive and toxic effects of methanol extract of Alchornea cordifolia leaf in male rats. Andrologia 47(9):1034-1040.
Crossref

 

Aouam K, Chaabane A, Loussaïef C, Romdhane FB, Boughattas NA, Chakroun M (2007). Les effets indésirables des antituberculeux : épidémiologie, mécanismes et conduite à tenir. Med. Mal. Infect. 37(5):253-261.
Crossref

 
 

Arhoghro EM, Ikeh CH, Eboh AS, Angalabiri-Owei B (2015). Liver function of wistar rats fed the combined ethanolic leaf extract of alchornea cordifolia and costus afer in paracetamol-induced toxicity. World J. Pharmaceut. Res. 4(5):01-12. 

 
 

Babu BH, Shylesh BS, Padikkala J (2004). Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 72(3):272-277.
Crossref

 
 

Banzouzi JT, Prado R, Menan H, Valentin A, Roumestan C, Mallie M, Pelissier Y, Blache Y (2002). In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid. J. Ethnopharmacol. 81(3):399-401.
Crossref

 
 

Bekro YA, Mamyrbekova JA, Boua BB, Bi FT, Ehile EE (2007). Etude ethnobotanique et screening phytochimique de Caesalpinia benthamiana (Baill.) Herend. et Zarucchi (Caesalpiniaceae). Rev. Sci. Nat. 4 (2):217-225.

 
 

Bhakta T, Banerjee S, Mandal SC, Maity TK, Saha BP, Pal M (2001). Hepatoprotective activity of Cassia fistula leaf extract. Phytomedicine 8(3):220-224.
Crossref

 
 

Blumberg H, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM (2003). American Thoracic Society/Center for Disease Control and Prevention/Infectious Discases Society of America treatment of tuberculosis. Am. J Respir Crit. Care Med.167:603-62
Crossref

 
 

Czinner E, Hagymasi K, Blazovics A, Kery A, Szoke E, Lemberkovics E (2001). The in vitro effect of Helichysi flos on microsomal lipid peroxidation. J. Ethnopharmacol. 77(1):31-35.
Crossref

 
 

Dwivedi Y, Rastogi R. Chander R. Sharma SK, Kapoor NK, Garg NK, Dhawan BN (1993). Hepatoprotective activity of picroliv against carbon-tetrachloride induced damage in rats. Ind. J. Med. Res. 92:1995-2000.

 
 

Effo KE, Kouakou-Siransy G, Irie-Nguessan G, Sawadogo RW, Dally IL, Kamenan AB, Kouakou LS, Kablan-Brou J (2013). Acute toxicity and antipyretic activities of a methanolic extract of Alchornea cordifolia leaves. Pharmacol. Pharm. 4(07):1-6.
Crossref

 
 

Germano MP, D'Angelo V, Sanogo R, Morabito A, Pergolizzi S, De Pasquale R (2004). Hepatoprotective activity of Trichilia roka on carbon tetrachloride-induced liver damage in rats. J Pharm Pharmacol. 53(11):1569-74.
Crossref

 
 

Graham GG, Scott KF, Day RO (2004). Alcohol and paracetamol. Aust. Prescribe. 27:14-15. Available at: 

View
Crossref

 
 

Huong NTT, Matsumoto K, Kasai R, Yamasaki K, Waranabe H. (1998). In vitro antioxidant activity of Vietnamese ginseng saponin and its components. Biol Pharmaceut Bull. 21(9):978-983.
Crossref

 
 

Kouakou-Siransy G, Sahpaz S, N'guessan GI, Datté JY, Brou JK, Gressier B, Bailleul F (2010). Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils. Pharm. Biol. 48(2):128-133.
Crossref

 
 

Madhu KP, Vijaya RA, Ganga RB (2012). Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rat. Asian. Pac. J. Trop. Biomed. 2(5):352-356.
Crossref

 
 

Manga HM, Brkic D, Marie DEP, Quetin-Leclercq J (2004). In vivo anti-inflammatory activity of Alchornea cordifolia. J. Ethnopharmacol. 92(2):209-214.
Crossref

 
 

Nkosi CZ, Opoku AR, Terblanche SE. (2005). Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low protein fed rats. Phytother. Res. 19(4):341-345.
Crossref

 
 

Nolan CM, Goldberg SV, Buskin SE (1999). Hepatotocixity associated with isoniazid preventive therapy. Jama 281:1014-1018.
Crossref

 
 

OCDE (1998) Système intégré harmonisé de classification des dangers pour la santé humaine et les effets environnementaux des substances chimiques. Organisation de coopération et de développement économiques, Paris, France.

 
 

Olaleye MT, Adegboye OO, Akindahunsi AA (2006). Alchornea cordifolia extract protects wistar albino rats against acetaminophen-induced liver damage. Afr. J. Biotechnol. 5(24):2439-2445

 
 

Olaleye MT, Kolawole AO, Ajele JO (2007). Antioxidant Properties and Glutathione S Transferases Inhibitory Activity of Alchornea cordifolia Leaf Extract in Acetaminophen-Induced Liver Injury. Iran. J. Pharmacol. Ther. 6:63-66.

 
 

Osadebe PO, Okoye FBC, Uzor PF, Nnamani NR, Adiele IE, Obiano NC (2012). Phytochemical analysis, hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats. Asian Pac. J. Trop. Med. 5(4):289-293 289-293
Crossref

 
 

Parthasarathy R, Nivethetha M, Brindha P (2007). Hepatoprotective activity of Caesalpinia bonducella seeds on paracetamol induced hepatotoxicity in male albino rats. Ind. Drugs 44(5):401-404.

 
 

Prabakan M, Anandan R, Devaki T (2004). Protective effect of Hemidesmus indicus against rifampicin and isoniazid-induced hepatotoxicity in rats. Fitoterapia 71(1):55-59.
Crossref

 
 

Pramod K, Deva RG, Lakshmayya, Ramachandra SS (2008). Antioxidant and hepatoprotective activity of tubers of Momordica tuberose Cogn. against CCl4 induced liver injury in rats. Ind. J. Exp. Biol. 46(7):510-513.

 
 

Reitman S, Frankel S. (1957). A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28(1):56-63.
Crossref

 
 

Repetto MG, Llesuy SF (2002). Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res. 35(5):523-534.
Crossref

 
 

Ronchetti F, Russo G (1971). A new alkaloid from Rauvolfia vomitoria. Phytochem. 10(6):1385-1388.
Crossref

 
 

Santhosh S, Sini TK, Anandan R, Mathew PT (2007). Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats. Eur. J. Pharmacol. 572(1):69-73.
Crossref

 
 

Saraswathy SD, Suja V, Prema G, Shyamala DC (1998). Effect of Liv. 100 against antitubercular drugs (isoniazid, rifampicin and pyrazinamide) induced hepatotoxicity in rats. Ind. J. Pharmacol. 30:233-238.

 
 

Shakya R, Rao BS, Shrestha B (2004). Incidence of hepatotoxicity due to antitubercular medecines and assessment of risk factors. Ann. Pharmacother. 38:1074-9
Crossref

 
 

Singh K, Singh N, Chandy A, Manigauha A (2012). In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals. Asian Pac. J. Trop. Biomed. 2:385-388.
Crossref

 
 

Wagner H, Bladt S, Zgainski EM (1983). Drogen analyse, Dünschicht chromatographische Analyse von Arzneidrogen. Springer Verlag Berlin Heidelberg New York. 522p.

 
 

Wu SJ, Wang JS, Lin CC, Chang CH (2004). Evaluation of hepatoprotective activity of legumes. Phytomedicine 8(3): 213-219.
Crossref

 
 

Yee D, Valiquette C, Pelletier M, Parisien I, Rocher I, Menzies D (2003). Incidence of serious side effects from first line antituberculosis drugs among patients treated for active tuberculosis. Am. J. Respir. Crit. Care Med. 167:1477.
Crossref