African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Anti-viral compounds from Jatropha curcas seed extract with anti-HIV-1 and anti-SARS-CoV-2 action

Elvino José de Sousa Ferrão
  • Elvino José de Sousa Ferrão
  • Faculty of Natural Sciences and Mathematics, Pedagogical University of Maputo, Mozambique.
  • Google Scholar
Edilson Armando De Germano Janeque
  • Edilson Armando De Germano Janeque
  • Secondary School of Unguana, Massinga District, Mozambique.
  • Google Scholar


  •  Received: 08 August 2022
  •  Accepted: 19 October 2022
  •  Published: 31 January 2023

References

Abdelgadir HA, Van Staden J (2013). Ethnobotany, ethnopharmacology and toxicity of Jatropha curcas L. (Euphorbiaceae): A review. South African Journal of Botany 88:204-218. Available at https://www.researchgate.net › publication › 259121505..
Crossref

 

Allard JP, Aghdassi E, Chau J, Tam C, Kovacs CM, Salit IE, Walmsley SL (1998). Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. AIDS 12: 1653-1659.
Crossref

 
 

Alamery SF, Algaraawi NI (2020). Phytochemical profile and Antifungal Activity of Stems and Leaves Methanol Extract from the Juncus Maritimus Linn. Juncaceae Family Against some Dermatophytes Fungi. The 8th International Conference on Applied Science and Technology (ICAST). AIP Conference Proceedings. 
Crossref

 
 

Al-Garaawi NI, Abu-Serag NA, Shaheed KAAA, Bahadly ZK (2019). Analysis of bioactive phytochemical compound of (Cyperus alternifolius L.) By using gas chromatography-mass spectrometry. IOP Conference Series: Materials Science and Engineering 571:1-19. 
Crossref

 
 

Agoramoorthy G, Chandrasekaran M, Venkatesalu V, Hsu MJ (2007). Antibacterial and Antifungal Activities of Fatty Acid Methyl Esters of the Blind-Your-Eye Mangrove from India. Brazilian Journal of Microbiology 38:739-742..
Crossref

 
 

Arora S, Kumar G, Meena S (2017). Screening and Evaluation of Bioactive Components of Cenchrus ciliaris L. By GC-MS Analysis. International Research Journal of Pharmacy 8(6).

View

Crossref

 
 

Ashwathanarayana R, Raja N (2018). Anti-Inflammatory Properties of Pavetta crassicaulis Bremek. Leaf and Flower Crude Extracts and Its Pure Compounds Collected from Western Ghats, Karnataka India. Asian Journal Pharmaceutical Clinical Research 11 (9):72-90.

View

Crossref

 
 

Bapia S, Srisombataa N, Ratanabunyongb S, Choowongkomonb K, Vajrodayaa S, Wongkantrakorna N, Duangsrisai S (2021). Isolation of Stigmasterol from Kra Don (Careya arborea Roxb.) and bioactivities of its crude extracts against free radicals and human immunodeficiency virus. Agriculture Natural Resources 55 (2021):33-42.

View

 
 

Beckstrom-Sternberg SM, Duke JA (1996). Handbook of medicinal mints (aromathematics): phytochemicals and biological activities. CRC press, pp. 409-417. USA.

 
 

Bessa NGF De, Borges JCM, Beserra FP, Carvalho RHA, Pereira MAB, Fagundes R, Campos SL, Ribeiro LU, Quirino MS, Chagas Junior AF, Alves A (2013). Preliminary phytochemical screening of native Cerrado plants of medicinal popular use by the rural community of the Vale Verde settlement- Tocantins.Brazilian Journal of Medicinal Plants 15(4):692-707.

View

Crossref

 
 

Chinsembu KC (2019). Chemical diversity and activity profiles of HIV-1reverse transcriptase inhibitors from plants. Brazilian Journal of Pharmacognosy 29:504-528.

View

Crossref

 
 

Dahake R, Roy S, Patil D, Rajopadhye S, Chowdhary A, Deshmukh RA (2013). Potential Anti-HIV Activity of Jatropha curcas Linn. Leaf Extracts. Journal of Antivirals Antiretrovirals 5(7):160-165. 
Crossref

 
 

Dan G, Castellar A (2015). Medicinal Plants with Antiretroviral Activity. Alumni Student Magazine at UNIABEU 3(6):8-24.

View

 
 

Darweesh KF, Ahmed, KM (2017). Anatomical and Phytochemical Study of Glossostemon bruguieri (Desf.) Sterculiaceae in Kurdistan Region of Iraq. Diyala Journal for Pure Sciences 13(1):23-41. 
Crossref

 
 

Fadilah F, Erlina L, Paramita RI, Istiadi KA, Handayani RRD (2020). Active constituents and Molecular Analysis of Psidium guajava Against Multiple Protein of SARS-CoV-2. Research Square. 
Crossref

 
 

Ferrão EJS, Janeque EDG (2019). Plants Used in the Treatment of Alcohol Dependence in the Municipality of Massinga: Parts Used, Active Principles, Relation to the Treatment Process. Presentation made during the 10th National Seminar on the Dissemination of Results of Projects Financed by the National Research Fund. August 21-23. Gloria Hotel. Maputo.

 
 

Gao H, Wen X, Xia CJ (2015). Hydroxymethyl Furfural in Chinese Herbal Medicines: Its Formation, Presence, Metabolism, Bioactivities and Implications. African Journal Traditional Complementary Alternative Medicine 12(2):43-54. 
Crossref

 
 

Gideon VA (2015). GC-MS analysis of phytochemical components of Pseudoglochidion anamalayanum Gamble: An endangered medicinal tree. Asian Journal of Plant Science Research 5(12):36-41.

View.

 
 

Godara P, Dulara BK, Barwer N, Chaudhary NS (2019). Comparative GC-MS Analysis of Bioactive Phytochemicals from Different Plant Parts and Callus of Leptadenia reticulate Wight and Arnerica Pharmacognosy Journal 11(1):129-140.

View

Crossref

 
 

Hadi MY, Mohammed GJ, Hameed IH (2016). Analysis of bioactive chemical compounds of Nigella sativa using gas chromatography-mass spectrometry. Journal of Pharmacognosy and Phytotherapy 8(2):8-24. 
Crossref

 
 

Hussein HM, Hameed IH, Ubaid JM (2016). Analysis of the Secondary Metabolite Products of Ammi majus and Evaluation Anti-Insect Activity. International Journal of Pharmacognosy and Phytochemical Research 8(8):1403-1411.

View

 
 

Idan SA, Al-Marzoqi AH, Hameed IH (2015). Spectral analysis and anti-bacterial activity of methanolic fruit extract of Citrullus colocynthis using gas chromatography-mass spectrometry. African Journal of Biotechnology 14(46):3131-3158. 
Crossref

 
 

Jaddoa HH, Hameed IH, Mohammed GJ (2016). Analysis of Volatile Metabolites Released by Staphylococcus aureus using Gas Chromatography-mass Spectrometry and Determination of its Antifungal Activity. Oriental Journal of Chemistry 32(4):1-9. Available at https://www.researchgate.net › 307.
Crossref

 
 

Jahan I, Tona MR, Sharmin S, Sayeed MA, Tania FZ, Paul A, Chy MNU, Rakib A, Emran TB, Simal-Gandara J (2020). GC-MS Phytochemical Profiling, Pharmacological Properties, and in Silico Studies of Chukrasia velutina leaves: A Novel Source for Bioactive Agents. Molecules 25:3536. 
Crossref

 
 

Jebastella J, Appavoo MR (2015). Bioactive components of Cynodon dactylon using ethanol extract. World Journal of Pharmaceutical Sciences 3(12):2388-2391.

View

 
 

Jeyasankar A, Chinnamani T (2017). Chemical composition and growth inhibitory activities of Solonum pseudocapsicum against Spodoptera litura and Helicoverpa armigera (Lepidoptera: Noctuidae). International Journal of Entomology Research 2(5):60-68.

View

 
 

Kamiyama H, Kakoki K, Shigematsu S, Izumida M, Yashima Y, Tanaka Y (2013). CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit. AIDS Research and Human Retroviruses 29 (2):279-88. 
Crossref

 
 

Kapewangolo P, Hussein AA, Meyer D (2013). Inhibition of HIV-1 enzyme, antioxidant and anti-inflammatory activities of Plectranthus barbatus. Journal Ethnopharmacol 149: 184-190.
Crossref

 
 

Kaur R, Sharma P, Gupta GK., Ntie-Kang F, Kumar D (2020). Structure- Activity-Relationship and Mechanistic Insights for Anti-HIV NaturalProducts. Molecules 25:2070. 
Crossref

 
 

Krishnamoorthy K, Subramaniam P (2014). Phytochemical Profiling of Leaf, Stem, and Tuber Parts of Solena amplexicaulis (Lam.) Gandhi Using GC-MS. International Scholarly Research Notices. 
Crossref

 
 

Matsuse IT, Lim YA, Hattori M, Correa M, Gupta MP (1999). A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes. Journal of Ethnopharmacology 64:15-22.

View

Crossref

 
 

Padmashree MS, Ashwathanarayana R, Raja N, Roopa B (2018a). Antioxidant, cytotoxic and nutritive properties of Ipomoea staphylina Roem & Schult. plant extracts with preliminary phytochemical and GCMS analysis. Asian Journal of Pharmacy and Pharmacology 4(4):473-492. 
Crossref

 
 

Padmashree MS, Roopa B, Ashwathanarayana R, Raja N (2018b). Antibacterial properties of Ipomoea staphylina Roem & Schult. plant extracts with comparing its preliminary qualitative phytochemical and quantitative GC-MS analysis. The Journal of the Society for Tropical Plant Research 5(3):349-369 
Crossref

 
 

Prasad DMR, Izam A, Khan MMR (2012) "Jatropha curcas: Plant of medical benefits". Journal of Medicinal Plants Research 6(14):2691-2699. Available at https://academicjournals.org › JMPR
Crossref

 
 

Ribeiro DO, Silva-Mann R, Ferreira OJM (2020). Fungicidal Potential of Extracts of Jatropha curcas L. GEINTEC Magazine 10(1):5302-5335. 
Crossref

 
 

Rocha NF (2013). Antioxidant and Antitumor Activity in Extracts of Jatropha curcas L. Master's Dissertation. Postgraduate Program in Interactive Processes of Organs and Systems. Institute of Health Sciences. Federal University of Bahia. Savior.

View

 
 

Sant'Anna CMR (2009). Molecular Modeling Methods for the study and design of bioactive compounds: Introduction. Chemistry Virtual Magazine 1(1):49-57. 
Crossref

 
 

Silva Filho AR, Gutierrez IEM, Almeida MZ, Silva NCB (2009). Scientific Surveillance of Jatropha curcas L. "Biodiesel Plant". Fitos Magazine 4(2):38-59.

View

Crossref

 
 

Siwe-Noundou X, Musyoka TM, Moses V, Ndinteh D, Mnkandhla D, Hoppe H, Bishop ÖT, Krause RWM (2019). Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches. Scientific Reports 9:4718. 
Crossref

 
 

Sharmila M, Rajeswari M, Jayashree I, Geetha DH (2016). GC-MS Analysis of Bioactive Compounds of Amarantus polygonoides Linn. (Amaranthaceae). International Journal of Applied and Advanced Scientific Research 1(1):174-180.

View

 
 

Shefeek S, Jaiganesh KP (2020). GC-MS analysis of ethanolic extract of Cabomba furcata Schult. & Schult.F: An aquatic plant. Journal of Pharmacognosy and Phytochemistry 9(4):1986-1991.

View

 
 

Shukla R, Banerjee S, Tripathi YB (2018). Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complementary and Alternative Medicine 18:156. 
Crossref

 
 

Sudha T, Chidambarampillai S, Mohan VR (2013). GC-MS Analysis of Bioactive Components of Aerial parts of Fluggea leucopyrus Willd. (Euphorbiaceae). Journal of Applied Pharmaceutical Science 3(5):126-130. 

 
 

Terefe EM, Okalebo FA, Derese S, Langat Moses K, Mas Claret E, Aljarba NH, Alkahtani S, Batiha G El Saber, Ghosh A, El Masry EA, Muriuki J (2022). In vitro anti-HIV and cytotoxic effects of pure compounds isolated from Croton macrostachyus Hochst. Ex Delile. BMC Complementary Medicine and Therapies 22:159. 
Crossref

 
 

Tyagi T, Agarwal M (2017). Phytochemical screening and GC-MS analysis of bioactive constituents in the ethanolic extract of Pistia stratiotes L. and Eichhornia crassipes (Mart.) solms. Journal of Pharmacognosy and Phytochemistry 6(1):195-206.

View

 
 

Valle LGD, Hernández RG, Ávila JP (2013). Oxidative stress associated to disease progression and toxicity during antiretroviral therapy in human immunodeficiency virus infection. Journal Virology Microbiology: 1-15.
Crossref

 
 

Venkata RB, Samuel LA, Pardha SM, Narashimha RB, Naga VKA, Sudhakar M, Radhakrishnan TM (2012). Antibacterial, Antioxidant Activity and GC-MS Analysis of Eupatorium odoratum. Asian Journal of Pharmaceutical and Clinical Research 5(2):99-106.

View

 
 

Verma VK, Kumar SR, Rani KV, Sehgal N, Prakash O (2015). Compound Profiling in Methanol Extract of Kalanchoe blossfeldiana (Flaming katy) Leaves Through GC-MS Analysis and Evaluation of its Bioactive Properties. Global Journal of Advanced Biological Sciences 1:38-49.

View

 
 

Vincent S, Arokiyaraj S, Saravanan M, Dhanraj M (2020). Molecular Docking Studies on the Antiviral Effects of Compounds from Kabasura kudineer on SARS-CoV-2 3CLpro. Frontiers in Molecular Biosciences 7:613401. 
Crossref

 
 

Zimila HE, Matsinhe AL, Malayika E, Sulemane AI, Saete VNC, Rugunate SC, Cumbane PJ, Magaia I, Munyemana F (2020). Phytochemical analysis and in vitro antioxidant and antimicrobial activities of hydroalcoholic extracts of the leaves of Salacia kraussii. Biocatalysis and Agricultural Biotechnology (30):1-6. Available at https://pubag.nal.usda.gov › catalog
Crossref