African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 February, 2013; 7(6)

February 2013

Mesua ferrea L.: A review of the medical evidence for its phytochemistry and pharmacological actions

The plant kingdom provides many plants with properties which are conducive to health and to secure the best results from the use of the plants as remedial agencies. Mesua ferrea Linn (Nagakesar) is a rare plant which is traditionally being used for its antiseptic, anti-inflammatory, blood purifier, anthelmintic, cardiotonic, diuretic, expectorant, antipyretic, purgative, antiasthmatic, antiallergic and several...

Author(s): Manoj Kumar Chahar, Sanjaya Kumar D. S., Geetha L., Lokesh T. and Manohara K. P.

February 2013

The protective effect of silymarin on the antioxidant system at rat renal ischemia/reperfusion injury model

The aim of this study is to reveal the protective effects of silymarin (SM) treatment on the generation of oxidative stress with rat renal ischemia/reperfusion (I/R) injury model. Thirty-two (32) Sprague-Dawley rats were evaluated in four groups. Group I (Sham), Group II (renal I/R), Group III (renal I/R injury + SM 100 mg per kg) and Group IV (renal I/R injury + SM 200 mg per kg) were designed to evaluate...

Author(s): Ayhanci Adnan, Ozkal Bilge, Kabay Sahin, Burukoglu Dilek, Guven Gül, Bayramoglu Gökhan, Senturk Hakan, Ustuner M Cengiz, Akyuz Fahrettin and Ozden Hilmi, MD

February 2013

The survey of look alike/sound alike (LASA) drugs available in hospitals in Thailand

A cross-sectional survey was designed to study look-alike, sound-alike (LASA) drugs in hospitals in Thailand. The questionnaires were developed and mailed to 1,380 hospitals throughout Thailand. The return rate was 11.16% or 154 hospitals, consisting of 5 tertiary hospitals (3.25%), 3 university hospitals (1.95%), 16 secondary hospitals (10.39%), 96 primary hospitals (62.34%), 26 private hospitals (16.88%) and 8 others...

Author(s): Teeraporn Chanakit, Jintana Napaporn, Todsapon Chiempattanakajohn, Somphon Sangkhawan and Sujitra Wichakot

February 2013

The effect of blood stasis syndrome on the pharmacokinetics of hydroxysafflower yellow A in human

Blood stasis, that is, the decrease of blood flow velocity and the increase of blood viscosity indicates hemorheological abnormalities and pharmacokinetic difference of drugs. Therefore, it is very important to investigate the pharmacokinetics of drugs in patients with blood stasis syndrome, which may influence absorption, distribution, metabolism, and excretion of drugs in blood. The aim of this study was to compare...

Author(s): Yan-Yan Jia, Jing Yang, Jin-Wen Wang, Yun Tian, Ai-Dong Wen and Zhi-Fu Yang

February 2013

A comparison of pre-emptive with preventive epidural analgesia in the patients undergoing major gynecologic surgery

Pain management is a crucial component in the care of the postoperative patient. Although pre-emptive analgesia is commonly used for the management of postoperative pain, timing the analgesic administration is unclear. This study was designed to compare the efficacy of pre-emptive epidural analgesia (EA) with preventive EA in the patients undergoing major gynecologic surgery. A randomized, double-blinded trial...

Author(s): Simin Atashkhoyi, Mehri Jafari Shobeiri, Alireza Azari Kalejahi and Pouya Hatami Marandi

February 2013

Bapedi phytomedicine and their use in the treatment of sexually transmitted infections in Limpopo Province, South Africa

Thirty four traditional healers from 17 municipalities, covering three districts of the Limpopo Province, were interviewed during the first half of 2011. Fourty seven plant species belonging to 32 families, mostly from the Asteraceae (9%), Asphodelaceae, Fabaceae and Hyacinthaceae (6% for each) were used to treat sexually transmitted infections (STIs) such as gonorrhoea, HIV/AIDS, nta (unspecified verneral disease -...

Author(s): Sebua Silas Semenya, Marthienus Johannes Potgieter and Lourens Johannes Christoffel Erasmus

February 2013

Effect of chemotherapy with cisplatin and rapamycin on HeLa cells in vitro

The aim of this study was to evaluate the effect of combination of rapamycin (RPM) with cisplatin on the proliferation of cervical cancer HeLa cells in vitro, as well as the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF). HeLa cells were treated with RPM and cisplatin, respectively or through combining them for 72 h. There were four groups in this...

Author(s): Lu Han, Jie-ling Wu and Li-xiao Yang

February 2013

Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

The preparation and electrochemical behavior of a carbon-paste electrode modified with an oxovanadium (IV) Schiff-base complex was studied. The modified electrode showed efficient catalysis in the electrochemical oxidation of methimazole (MMZ), an anti-hyperthyroid drug. The catalytic effect was observed for VIII oxidation peak which was produced via disproportionation of VIV in acidic solution. The diffusion...

Author(s): Fahimeh Jalali, Loghman Miri and Mahmoud Roushani

February 2013

Neuropharmacological studies on ethyl acetate fraction of Securinega virosa root bark extract

This study was conducted to evaluate the neuropharmacological activities of the ethyl acetate fraction of methanol root bark extract of Securinega virosa using in vivo models in laboratory animals. The fraction (125, 250 and 500 mg/kg) did not protect the animals against tonic hind limb extension induced by electroshock but produced a dose-dependently protection of animals against clonic spasm...

Author(s): Magaji Mohammed Garba, Yaro Abdullahi Hamza, Musa Aliyu Muhammad, Anuka Joseph Akpojo, Abdu-Aguye Ibrahim and Hussaini Isa Marte,

February 2013

Ameliorative effects of rutin and ascorbic acid combination on hypercholesterolemia-induced hepatotoxicity in female rats

It has been shown that female rats are more responsive to dietary cholesterol challenge than male and also, hypercholesterolemia induction is easier in female rats. The present study was designed to investigate the effects of rutin (RT) and ascorbic acid (AA) combination on high cholesterol diet (HCD)-induced hepatic damage in female Wistar rats. Rats were randomly divided into four groups and fed by respective...

Author(s): Abdulaziz M. Aleisa, Hatem M. Abuohashish, Mohammed M. Ahmed, Salim S. Al-Rejaie, Osama A. Alkhamees and Abdulaziz S. Alroujayee

February 2013

In vivo skin irritation potential of a cream containing Moringa oleifera leaf extract

The aim of the present study was to evaluate the skin irritation potential of a cream containingMoringa oleifera leaf extract. Skin irritation potential of a cream containing M. oleifera leaf extract (3%) versus base was investigated by performing an in-vivo visual scoring (skin irritation), patch test and erythema index for long term study by using non-invasive instrumental assessment Mexameter...

Author(s): Atif Ali, Naveed Akhtar, Ahmad Mahmood Mumtaz, Muhammad Shoaib Khan, Furqan Muhammad Iqbal and Syed Sauod Zaidi

February 2013

Isolation and identification of phytochemical constituents from the fruits of Acanthopanax senticosus

Phytochemical constituents were isolated from the fruits of Acanthopanax senticosus by repeated chromatography and prep-HPLC. Their structures were identified as β-sitosterol (1), daucosterol (2), p-hydroxybenzoic acid (3), vanillic acid (4), uracil (5), eleutheroside K (6), songoroside A (7), copteroside B (8) and myo-inositol (9) by spectroscopic analysis. Among...

Author(s): Jeong Min Lee, Dong Gu Lee, Ki Ho Lee, Seon Haeng Cho, Kung-Woo Nam, and Sanghyun Lee

February 2013

Accelerated extraction of Xanthone from Mangosteen pericarp using ultrasonic technique

Mangosteen pericarp has been used for long time as traditional medicine. One of main active ingredient in M. pericarp is xanthone. Xanthone has remarkable effects on cardiovascular health, antiviral and anti-inflammatory. Ultrasonic Assisted Extraction (UAE) was employed to extract xanthone from dried M. pericarp and compared with soxhlet extraction and maceration. The UAE was applied by various...

Author(s): Nuttawan Yoswathana

February 2013

Comparative mosquito repellent efficacy of alcoholic extracts and essential oils of different plants against Anopheles Stephensi

Mosquitoes control and personal protection from mosquito's bites is one of the serious ways for preventing of contagious diseases distribution. Mosquitoes in addition to the localsymptoms (itching, redness and irritation) can cause transmission of fatal and dangerous...

Author(s): Mohammad Barat Shooshtari, Hamed Haddad Kashani, Siamak Heidari and Ruhollah Ghalandari

February 2013

Effect of finasteride on lipid profile in individuals with androgenetic alopecia

Atherosclerosis constitutes one of the most frequent diseases and one of the important predisposing factors for atherosclerosis is lipid profile change. Androgen changes lipid profile, mainly high density lipoprotein (HDL), and oral finasteride are used for treating androgenetic hair loss as a risk factor for atherosclerosis. This study was conducted in order to determine the lipid profile changes by 1 mg finasteride...

Author(s): Seied Reza Seied Mohammad Doulabi, Hossein Kavoussi, Danial Isapour, Amirhossein hashemian and Ali Taheriniya