June 2013
Differentiation of stem and progenitor cells from bone marrow in activated dendritic cells and lymphocytes with anti-malignant properties
Dendritic cells (DCs) have been characterized as powerful antigen-presenting cells (APCs), which possess the abilities for immune modulation and are used in composition of anti-malignant vaccines and gene-engineered products. By appropriate cultivation, modifications of DCs have shown abilities for an enhanced expression of specific effector molecules. Studies on their biology are...
June 2013
Analysis of the polysaccharides from Urtica angustifolia and their anti-fatigue activity
The crude polysaccharides (UA) were obtained from Urtica angustifolia by hot water extraction, 80% ethanol precipitation and deproteination by using sevage reagent in a yield of 1.6%. The polysaccharides were fractionated into six fractions. Their sugar compositions and structures were analyzed by high performance liquid chromatography (HPLC) and nuclear magnetic resonance spectrometer (NMR). The HPLC analysis...
June 2013
Effect of cooking methods on tetracycline residues in pig meat
Tetracyclines (TCs) are widely used for disease control in the livestock and poultry industry due to their broad spectrum of activity and affordability. However, some residues have been found to remain in the animals during slaughter and subsequent consumption. The potential of different cooking methods as strategies to reduce TC residues in pork were therefore investigated. Samples of pig muscles containing...
June 2013
Impact of high hydrostatic pressure on gel formation of low methoxylpectin
The effect of different treatment conditions (pressure, treatment time, and temperature), as well as composition of pectin solution (Pectin, Ca++ ion and sugar concentration, pH) on gel formation of two types of low methoxylpectins were investigated. The results have shown that with increasing pressure, time or temperature during high hydrostatic pressure (HHP) treatment, the gel hardness increased continuously. Up...
June 2013
Pharmaceutical evaluation of glibenclamide products available in the Jordanian market
The pharmaceutical quality of five generics of glibenclamide that are available in the Jordanian market was assessed according to the British Pharmacopoeia (BP) monograph (2009). Similarly, the originator glibenclamide (Daonil®) which was obtained from the Saudi market was subjected to analysis and used as a reference product. All products were found satisfactory in terms of identification and related substances as...
June 2013
Acetylcholinesterase inhibitors used or tested in Alzheimer’s disease therapy; their passive diffusion through blood brain barrier: In vitro study
Although the information about Alzheimer’s disease (AD) etiology is still unclear; acetylcholinesterase inhibitors still play a major role in symptomatic treatment of AD. Unfortunately, a relevant argumentation is complicated since information about real drug concentration in the brain or time-dependent blood-brain barrier (BBB) distribution studies are still quite rare. In this in vitro study,...
June 2013
Design and optimization of self-nanoemulsifying drug delivery systems of simvastatin aiming dissolution enhancement
The aim of this work was to improve the in vitro dissolution of simvastatin through development of self-nanoemulsifying tablets. Various modified oils, surfactant and co-surfactant mixtures were used to prepare different self-nanoemulsifying drug delivery systems (SNEDDS) whose composition was optimized using drug-solubility, ternary phase diagram, system stability and droplet size distribution studies....
June 2013
Investigation of factors effected dissolution variations of hydroxypropyl methylcellulose capsule
The objective of this study was to identify if the root cause of dissolution was from the HPMC shell differences and/or the insufficient robustness of dissolution method. Studying the dissolution behavior of 40 and 150 mg granules (with and without shells), followed by capsule dissolution with switched shells, the sink condition can be verified by the extent of granule dissolutions with switch shells. The effect of the...
June 2013
In vitro antioxidant, analgesic and cytotoxic activities of Sepia officinalis ink and Coelatura aegyptiaca extracts
The present study aims to evaluate the antitumor, antioxidant and anti-inflammatory activities of two molluscan extracts, Sepia officinalis, ink extract (IE) and Coelatura aegyptiaca extract (CE). The antioxidant activities of both extracts were evaluated using 1,1- diphenyl-2-picrylhydrazyl (DPPH) scavenging and lipid peroxidation assays. The analgesic effects...
June 2013
Synthesis and neuropharmacological evaluation of some new isoxazoline derivatives as antidepressant and anti-anxiety agents
A series of 3-(furan-2-yl)-5-(substituted phenyl)-4,5-dihydro-1,2-oxazole derivatives (2a to j) were synthesized by Claisen Schmidt condensation of 2-acetyl furan with different types of aromatic aldehyde, as chalcones and their subsequent cyclization to 4,5-dihydro-1,2-oxazole with hydroxylamine hydrochloride. The chemical structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C-NMR and...
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