February 2014
Feasibility study of manufacturing coated tablet lipase from Yarrowia lipolytica
Many studies have provided evidence to use microbial enzyme lipase such as Yarrowia lipolytica lipase as substitute of pancreatic lipase. However Y. lipolytica lipase lowest resistance at acid pH (1 to 2) limits its application in pharmaceutical industries. In order to improve Y. lipolytica lipase resistance to low acid pH, our study was devoted more particularly to coating lipase tablets by Eudragit L30D-55. Lipase...
February 2014
Effect of the alkaline treatment conditions on the tableting performance of chitin obtained from shrimp heads
Chitin is a natural polymer with a potential pharmaceutical application since its exhibits some biodegradability, biocompatibility and relative non-toxicity. It is obtained from crustacean’s exoskeletons by treatment with alkalis and mineral acids followed by a depigmentation step. In this work, the effect of alkaline treatment on tableting properties such as compact tensile strength and disintegration time and...
February 2014
Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma
A simple and cost effective high performance liquid chromatography (HPLC) method was developed for determination of tizanidine in human plasma using liquid extraction technique. The assay of tizanidine was performed after extraction of drug from plasma using diethyl ether as extraction solvent. The isocratic elution was performed in Agilent, Zorbax SB-C18, 4.6 × 150 mm column maintained at 30°C with mobile...
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