African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 22 February; 8(7)

February 2014

Feasibility study of manufacturing coated tablet lipase from Yarrowia lipolytica

Many studies have provided evidence to use microbial enzyme lipase such as Yarrowia lipolytica lipase as substitute of pancreatic lipase. However Y. lipolytica lipase lowest resistance at acid pH (1 to 2) limits its application in pharmaceutical industries. In order to improve Y. lipolytica lipase resistance to low acid pH, our study was devoted more particularly to coating lipase tablets by Eudragit L30D-55. Lipase...

Author(s): Wazé A. Mireille Alloue-Boraud, Karim Amighi, Florent K. N’Guessan,  Rose Koffi-Nevry and Jacqueline Destain

February 2014

Effect of the alkaline treatment conditions on the tableting performance of chitin obtained from shrimp heads

Chitin is a natural polymer with a potential pharmaceutical application since its exhibits some biodegradability, biocompatibility and relative non-toxicity. It is obtained from crustacean’s exoskeletons by treatment with alkalis and mineral acids followed by a depigmentation step. In this work, the effect of alkaline treatment on tableting properties such as compact tensile strength and disintegration time and...

Author(s): John Rojas,  Christian Hernandez and Diana Trujillo

February 2014

Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma

A simple and cost effective high performance liquid chromatography (HPLC) method was developed for determination of tizanidine in human plasma using liquid extraction technique. The assay of tizanidine was performed after extraction of drug from plasma using diethyl ether as extraction solvent. The isocratic elution was performed in Agilent, Zorbax SB-C18, 4.6 × 150 mm column maintained at 30°C with mobile...

Author(s): Tariq Ali, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui, Huma Ali, Farrukh Rafiq Ahmed, Iyad Naeem Muhammad and Muhammad Fayyaz