African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 November, 2011; 5(20)

November 2011

Preliminary phytochemical screening and in vitro anti-Helicobacter pylori activity of extracts of the leaves of Lippia javanica

The antimicrobial activity of crude extracts of Lippia javanica was investigated against 31Helicobacter pylori strains by agar well diffusion. The minimum inhibitory concentration (MIC) was determined by spectrophotometric analysis at 620 nm using broth micro dilution method and the rate of kill by the broth dilution method. H. pylori standard strain NCTC 11638 was also included as a positive...

Author(s): L. P. Nkomo, E. Green and R. N  Ndip,

November 2011

Effect of Bidens bipircadta L. on mouse uterine cervix cancer

1College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. 2College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China. 3College of Environment and Chemistry Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.

Author(s): Huaiping Shi, Yamei He, Qingwang Li, Tao Feng, Guoxia Geng and Jian Li

November 2011

Efficacy and safety of prostacyclins therapy in pulmonary arterial hypertension: A meta-analysis

Prastacyclins have played a prominent role in the treatment of pulmonary arterial hypertension (PAH). To evaluate the efficacy and safety of prostacyclins therapy in PAH, a search was performed in PubMed, OVID and EMBASE to identify relevant articles randomized controlled trials and a meta-analysis was conducted. Ten documents (including 1261 patients) accorded to the demand of enrollment. Compared with placebo...

Author(s): Xi-Qian Xing#, Bei Han#, Xu-Wei Wu, Yi Xiao and Shang-Jie Wu

November 2011

Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide

A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbensextract demonstrated direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results indicated direct...

Author(s): N. Ebrahim and R. A. Uebel

November 2011

Crevicular tartrate resistant acid phosphatase activity and rate of tooth movement under different continuous force applications

This study investigated specific activities of tartrate resistant acid phosphatase (TRAP) in gingival crevicular fluid (GCF) and cumulative canine movement when two orthodontic forces were applied during orthodontic treatment. Each selected subjects (n = 12) randomly received a 100 and 150 g force for canine retraction either on the right or left site of maxillary arch. GCF was collected at the mesial and...

Author(s): Rohaya Megat Abdul Wahab, Maryati Md Dasor, Sahidan Senafi, Asma Alhusna Abang Abdullah, Abdul Aziz Jemain, Nurfathiha Abu Kasim, Zulham Yamamoto and Shahrul Hisham Zainal Ariffin

November 2011

Effects of crude extracts and fractions of Moringa stenopetala (Baker f) Cufodontis leaves in normoglycemic and alloxan-induced diabetic mice

Moringa stenopetala leaves are traditionally employed for the treatment of diabetes mellitus in Ethiopia. Previous studies confirmed that the aqueous crude extract of the leaves of this plant and fractions isolated from these extracts have hypoglycemic and antihyperglycemic effects. Whether the active components are also present in the ethanol extract and its fractions, however, have not yet been investigated. The...

Author(s): Aschalew Nardos, Eyasu Makonnen and Asfaw Debella

November 2011

Optimization of extraction process and phytochemical investigations of Spathodea campanulata flowers

Since ancient times, plants have been an exemplary source of medicines. Researches conducted in last few decades on the plants mentioned in ancient literature or used as folk medicines have shown potential of phytoconstituents in the treatment of various diseases.Spathodea campanulata is a plant that has been frequently used as a medicine which belongs to the genus Spathodea and family...

Author(s): Zahid Zaheer, Aniruddha P. Paithankar, Sagar D. Deshpande and Subur Khan

November 2011

A validated HPLC method for the determination of levobupivacaine in plasma and its application to pharmacokinetic studies in Chinese people

1Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, P. R. China. 2Department of Pharmaceutical, Shanghai New Drugs Research and Development Center, P. R. China.

Author(s): Liu ji, Zhou xiao and Jiang jie

November 2011

Comparative assessment of drug interactions in pediatrics at private and public sector hospitals of Sargodha and Faisalabad

The present study was performed in the cities of Faisalabad and Sargodha, and pediatric in-patient prescriptions were collected from four private and D.H.Q hospitals of these two cities. The collected data of 1420 prescriptions was analyzed for drug interactions by using the software developed by the Medical Letter. The drug interactions found were divided into severe, moderate and mild depending on the type of...

Author(s): Sajid Bashir, Tahir Aqeel, Muhammad Usman, Shahiq uz Zaman, Asadullah Madni, Haji M. Shoaib Khan, Abubakar Munir and Arshad Mahmood

November 2011

Zerumbone protects HEK 293 cells from irradiation-induced DNA damage via activating Keap1/Nrf2/ARE pathway

Zerumbone, a sesquiterpene compound occurring in tropical ginger Zingiber zerumbet Smith, was shown to attenuate the 60Co γ-rays irradiation-induced cell damage and cell apoptosis in HEK 293 cells. The γ-H2AX focus formation and the protein expression levels, which were important markers of ionizing radiation-induced DNA double-strand breaks, were significantly inhibited too. To elucidate...

Author(s): Cuiyan  Tang, Mingjun Bi, Hongmei Yu, Wei Chen and Jinxiu Wang

November 2011

Evaluation of biochemical and microbiological effects of Cordyline dracaenoides Kunth (Uvarana) barks

Cordyline dracaenoides, known as Uvarana, is a tree that is found and spread throughout the region of “Campos Gerais” in the State of Parana, Brazil. In this work, the immunomodulatory and citotoxicity of crude extract and microbiological activity of hexanic, chloroformic, ethyl acetate and methanolic extracts were investigated. Furthermore, the phytochemical screening of the partionated extracts was...

Author(s): Flávio Luís Beltrame, Carla Cristine Kanunfre, Bruno Rainho, Elaine Kiatkoski, Francine Mioduski, Marcelo Henrique Kravicz and Luís Antônio Esmerino.

November 2011

Synthesis and characterization of porous hollow silica nanoparticles using ZnSe core as template for drug delivery application

In this contribution, porous hollow silica nanoparticles using inorganic nano sized ZnSe as template were prepared. The hydrothermal method was used to synthesize pure ZnSe nanospheres material. The ZnSe/SiO2 core-shell nanocomposites were prepared using a simple sol-gel method successfully. The hollow silica nanostructures were achieved by selective removal of the ZnSe core. The morphology, structure and...

Author(s): Soodabe Gharibe, Shahrara Afshar and Leila Vafayi

November 2011

Cholinesterase and lipoxygenase inhibition of whole plant Withania somnifera

To discover new therapeutically effective and safe cholinesterase and lipoxygenase inhibitors, crude methanol extract and subsequent solvent fractions of Withania somnifera Dunal were screened for their inhibitory profile. Results revealed marked overall inhibition. Against acetylcholinesterase, the IC50 values were in the range of 69 to 111 µg/ml, except hexane fraction. Similarly, profound...

Author(s): Haroon Khan, Shafiq Ahmad Tariq, Murad Ali Khan, Inayat-Ur-Rehman, Rukhsana Ghaffar and Saifullah,

November 2011

Self-regulation and education on interactive advertising of pharmaceuticals for human use

Nowadays, many objects are being promoted in the internet. Among them are pharmaceutical products intended for human use and/or consumption. Although the laws try to protect the consumer from potential fraudulent activities relating to those products, it is still not sufficient. To complement the legal standard, pharmaceutical business organizations are self-regulated. A set of best practices in advertising has been...

Author(s): David López Jiménez, Antonio J. Monroy Antón and Gema Sáez Rodríguez

November 2011

In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate

This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by...

Author(s): Che Nor Zarida C. S., Fauziah O., Arifah A. K., Azfar Rizal A., Nazri M. Y., Ahmad Hafiz Z., Rusnah M., Mohd Azam Khan G. K. and Hasni Idayu S.

November 2011

Enlisting the scientifically unnoticed medicinal plants of Pakistan as a source of novel therapeutic agents showing anti-venom activity

Snake bite envenoming is a global occupational hazard and most of the people of the world trust in traditional medicine for snake poisoning. The present review elaborates scientifically un-investigated/ ignored medicinal plants of Pakistan showing chemical constituents of natural origin with possible mechanisms showing anti-venom activity. This review enlists 35 plants with their families, distribution in Pakistan,...

Author(s): Muhammad Hassham Hassan Bin Asad, Ghulam Murtaza, Sami Siraj, Shujaat Ali Khan, Saira Azhar, Muhammad Sikander Hussain, Tariq Ismail, Muhammad Shahzad Hussain and Izhar Hussain

November 2011

Assessment of anti erythmic and skin whitening effects of milk thistle extract

This study was intended to explore the effects of a topical cream (w/o emulsion) of milk thistle(Silybum marianum) extract against its vehicle as control on skin erythma and skin melanin. Milk thistle extract was entrapped in the inner aqueous phase of w/o emulsion. The vehicle (base without extract) and the active formulation (containing 4% extract) were applied by volunteers (n = 11) for a period of 12 weeks....

Author(s): Akhtar Rasul, Naveed Akhtar, Barkat Ali Khan, Tariq Mahmood, Shahiq uz Zaman, Atif Ali, Haji M. Shoaib Khan and Rashida Parveen

November 2011

Phenolic content and antioxidant capacity of four Cnidoscolus species (Euphorbiaceae) used as ethnopharmacologicals in Caatinga, Brazil

This study aimed to investigate the phenolic content and antioxidant capacity of four species ofCnidoscolus (C. infestus Pax & K. Hoffm., C. pubescens Pohl, C. quercifolius Pohl and C. urens [L.] Arthur) used as ethnopharmacologicals in the Caatinga. The total phenolic content (TPC), total tannin content (TTC) and total flavonoid content (TFC) were analyzed by spectrophotometric method. The...

Author(s): Tadeu J. S. Peixoto Sobrinho, Valérium T. N. A. Castro, Antonio M. Saraiva, Diego M. Almeida, Elvis A. Tavares and Elba L. C. Amorim

November 2011

Effect of Astragalus mongholicus injection liquid on the immunity function in children with congenital heart disease (CHD) after undergoing cardiopulmonary bypass surgery

1Department of Pediatrics, First Affiliated Hospital of School of Medicine of Shantou University, Shantou, PR China. 2Department of Urinary Surgery, First Affiliated Hospital of School of Medicine of Shantou University, Shantou, PR China. 3Department of Orthopedic Surgery, Chinese University of Hong Kong, Hong Kong, PR China. 4Department of Cardiothoracic Surgery, First Affiliated Hospital of School of...

Author(s): Li Tong, Yu Shaoyi, Zhang Ge and Huang Weizhe

November 2011

Biological screening of Viola betonicifolia Smith whole plant

Crude methanolic extract as well as subsequent solvent fractions of Viola betonicifolia (VB) whole plant were tested for various in-vitro biological activities, including nematicidal, antioxidant, larvecidal, phytotoxic and cytotoxic. All extracts were also tested for their total flavonoid and phenolic contents. A dose dependent effect was observed against both nematodes. Ethyl acetate fraction was...

Author(s): Naveed Muhammad and Muhammad Saeed

November 2011

Protective effect of ethanolic root extract of Plumbago indica L. on paracetamol induced hepatotoxicity in rats

Ethanolic extract of the root of Plumbago indica was investigated for hepatoprotective activity against paracetamol induced liver damage. Various biochemical parameters were studied to evaluate the hepatoprotective activity of the ethanolic root extract. Total bilirubin, total protein, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐Glutamyl transferase, total...


November 2011

Development and validation of simple isocratic high performance liquid chromatography-ultraviolet (HPLC-UV) method for determination of safflower yellow in Carthamus tinctorius (L.)-loaded nanostructured lipid carriers (NLC)

Carthamus tinctorius L. (safflower) is the traditional plant that is widely used in many regions around the Asia, including Thailand. With many reported biological activities, our group decided to formulate the cosmeceutical containing the florets extract of the plant. For enhancing the bioavailability of absorption of substances from its florets, the special carrier; nanostructured lipid carriers or nanostructured...

Author(s): Naphatsorn Kumar, Somsak Tharatha and Chaiyavat Chaiyasut

November 2011

Reverse phase high performance liquid chromatographic (HPLC) method for nimesulide tablets dosage form prepared for in vivo in vitro correlation (IVIVC) studies

The cost effective and simple method of reverse phase high performance liquid chromatographic (HPLC) method was successfully developed for the assaying of nimesulide (NM) in tablets, formulated for in vivo in vitro correlation (IVIVC) studies. The assay consisted of isocratic elution of nimesulide in Hiber RT 254-4.6 Purospher STAR RP-18 column using mobile phase composed of acetonitrile, phosphate buffer (pH...

Author(s): Muhammad Hanif, M. Harris Shoaib, Rabia Ismail Yousuf, Ahmad Khan, Sohail Anwer, Akhter Rasul, Shahnila Sattar and Hafiz Muhammad Arshad