African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 November, 2013; 7(44)

November 2013

Screening of antibacterial activity of 20 Chinese herbal medicines in Yunnan

The 80% ethanol extracts from 20 Chinese herbal medicines collected in Yunnan Province, China, were screened for antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli (EC) and Pseudomonas aeruginosa (PA), including antifugal activity against Candida albicans (CA) by the agar hole diffusion test. The extracts were prepared through macerating at...

Author(s): Ding Yan-Jiao, Zuo Guo-Ying, Hao Xiao-Yan, Wang Gen-Chun and Han Jun

November 2013

Polymeric microparticles containing protein prepared using a controllable combination of diffusion and emulsification steps as part of the salting out procedure

The key to success of proteins as biopharmaceuticals is to have in place an efficient drug delivery system that allows in gaining access to their target sites. A novel procedure of preparing ovoalbumin-loaded Eudragit® S100 microparticles, based on combining salting out and double emulsion-evaporation steps was developed. The ratio of a water miscible solvent (acetone and isopropanol) to a non-water-miscible solvent...

Author(s): González Álvarez Erika, Castro Ríos Rocío, Luna Olvera Hugo Alberto, González Horta Azucena, Galindo Rodríguez Sergio Arturo and Chávez Montes Abelardo

November 2013

A pilot study on the novel effect of Neu-P11 on reducing the intraocular pressure in normotensive rabbits

Melatonin is involved in the regulation of intraocular pressure. To evaluate the effect of a melatonin receptor agonist (Neu-P11) on intraocular pressure, a multiple-dose study was performed in 30 ocular normotensive rabbits by regularly measuring the intraocular pressure within 7 h. The results indicated that topical applications of Neu-P11 and melatonin could both produce dose-dependent reductions in intraocular...

Author(s): Shou-min Xi, Ping-yuan Gong, Shi-peng Li, Wei-dong Yin and Moshe Laudon

November 2013

Inhibitory effect of betulinic acid and 3β-acetoxybetulinic acid on rat platelet aggregation

Platelet aggregation is one of the major causes of cardiovascular diseases. Our search for bioactive molecules from nature, led to the isolation of betulinic acid (BA) and structural modification of BA to 3β-acetoxybetulinic acid (BAA). Both inhibited blood platelet aggregation induced by thrombin, adenosine diphosphate (ADP) and epinephrine. BAA showed an enhance inhibition of platelet aggregation, in the...

Author(s): Habila A. J, Habila J. D, Shode F. O, Opoku A. R, Atawodi S. E and Umar I. A

November 2013

Activity exerted by a benzamide derivative on injury by ischemia/reperfusion in an isolated heart model

Several studies indicate that some benzamide-derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the effects exerted by the benzamide derivatives on cardiac injury caused by ischemia/reperfusion (I/R). In this experimental study, a new benzamide-derivative was synthetized with the objective of evaluating its activity on I/R in an I/R model of rat heart using the Langendorff...

Author(s): Rosas-Nexticapa Marcela, Figueroa-Valverde Lauro, Díaz-Cedillo Francisco, García-Cervera Elodia, Pool-Gómez Eduardo, Sarabia-Alcocer Bety and López-Ramos Maria