September 2012
Novel modified release tableted microspheres of ibuprofen and misoprostol in a combined formulation: Use of software DDSolver®
The current study was aimed to develop a stable sustained release drug delivery system for ibuprofen and a cytoprotective agent misoprostol in a combined dosage form. Non-aqueous emulsion solvent evaporation method was used to prepare ibuprofen microspheres. Ethylcellulose (EC) and Hydroxypropyl methylcellulose (HPMC) were used as the release retarding polymers in combination. Ibuprofen microspheres were prepared...
September 2012
Seroepidemiological surveillance of antitetanus antibodies in Pakistani childbearing women: A population based survey
Maternal and Neonatal Tetanus is a severe, often fatal ailment characterized by sweeping augmented strictness and convulsive spasms of skeletal muscles. Vaccination is the most steadfast method of forbearance against this disease and has inculcated to lessen mortalities. The present study was carried out with a view to assess the serum levels of tetanus antitoxins in randomly selected rural and urban women to find out...
September 2012
Efficacious formulation of anti-malarial dry suspension for pediatric use
This study was designed for concealing the bitter taste of an anti-malarial drug, artemether, by using various coating substances. Four granular formulations (formulations A, B, C and D) of artemether were prepared using different excipients and then were coated using methocil™ E5 and opadry® enteric solutions in a simple coating pan. In the initial 2 min, the cumulative percentage amount of drug release...
September 2012
Protective effect of Panax ginseng against N-acetyl-p-aminoÂphenol-induced hepatotoxicity in rats
Panax ginseng (PG) has been commonly used as medicinal herb for the treatment of various diseases in Eastern Asia for thousands of years. This study was designed to investigate the protective effect of PG against paracetamol-(N-acetyl-p-aminophenol; APAP)-induced liver damage in rats. Thirty-two albino Wistar rats were divided into four groups: Group C (control); Group APAP (gavaged orally with APAP...
September 2012
mRNA expression of aquaporin protein 1 and 7 in rat model of slow transit constipation (STC)
Water channels play important role in colon, and might be involved in constipation disease. To understand the mRNA expression changes of aquaporin protein 1 and 7 (AQP1, AQP7) in a rat model of slow transit constipation (STC), a rat model of slow transit constipation was designed, and the correlated changes of aquaporin protein 1 and 7 at the mRNA level were examined. The rat model of slow transit constipation was...
September 2012
Is chloroquine making a comeback?
Malaria remains one of the leading causes of disease and death in the tropics, mainly of children under 5 years of age. Chloroquine began as a first-line antimalarial in 1946; it became the corner stone of antimalarial chemotherapy for the next 40 years. It is one of the least expensive antimalarials available and is still in widespread use. Chloroquine can be taken both as prophylactic and as a treatment. For decades,...
September 2012
The effects of sevoflurane on short memory impairment in mice
This study was aimed at investigating the effects of sevoflurane on short memory impairment and the relative synaptic mechanism. To achieve this, at 12, 24 and 72 h after the mice were exposed to 1.5% sevoflurane for 1 h, the spontaneous alternation and locomotor activity was assessed by Y maze and the short term potentiation (STP) were measured with extracellular recording technique in hippocampal slices. Results...
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