September 2012
Amoxycillin/clavulanic acid combinations (Augmentin® 375 and 625 tablets) induce - oxidative stress, and renal and hepatic damage in rats
Amoxicillin/clavulanic acid has become one of the most widely prescribed antibiotics being advocated by WHO for treatment of infection. Its efficacy and potential to inhibit microorganisms had led to their increased use. There is the possibility that the drug may have potential toxic effects on humans following consumption. The present investigation was therefore undertaken to study the status of antioxidant defence...
September 2012
Enhanced memory processes under the influence of herbal drug Somina and its effect on brain serotonin
A progressive decline in memory with advancing age is an established fact. The purpose of the present study was to investigate the effects of Somina (herbal drug) on memory processes of rat. Somina (285 mg/kg-body weight) was administered orally in rats for 29 consecutive days. It is observed in the present study that Somina is responsible for the enhanced memory related behavior significantly in both male and female...
September 2012
Neuroprotective effect of Lactuca sativa on glucose/serum deprivation-induced cell death
This study was planned to investigate whether Lactuca sativa is capable of protecting neurons against glucose/serum deprivation (GSD)-induced cell injury, an in vitro model of brain ischemia. Two neuron-like cells, rat pheochromocytoma-derived cell line (PC12) and mouse neuroblastoma-like cell line (N2a), were cultivated for 24 h in standard media or for 6 and 12 h in GSD condition in the absence or...
September 2012
Efficacy of losartan and combination of losartan plus hydrochlorothiazide for high blood pressure treatment
Hypertension is one of the most common cardiovascular risk factors in adult population. Even values of high normal blood pressure are linked to increased risk of major cardiovascular events and only minority of patients reach the target values with antihypertensive medications prescribed. We wanted to demonstrate the efficacy and safety of treatment with losartan and/or combination of losartan plus...
September 2012
Study on the DNA repair gene ERCC1 and XPD polymorphism in prediction of survival of glioma patients with chemotherapy
Tumors of the central nervous system (CNS) account for about 2% of all the cancers, and gliomas are the most common tumors of CNS. Although there is a great improvement of the diagnosis and treatment, the prognosis of glioma is poor and this tumor remains incurable. We conducted a perspective case cohort study to examine the role of genetic polymorphisms in Excision repair cross-complementing group 1...
September 2012
The effect of hydrophobicity/hydrophilicity balance of three kinds of adjuvants on pridinol mesylate orally disintegrating tablets and its quality assessment
This study was aimed at investigating the effects of 3 kinds of adjuvants on the disintegrating ability of pridinol mesylate orally disintegrating tablets (PMODT), and evaluating the quality of PMODT. The hydrophobic balance of 3 adjuvants (polyvinylpolypyrrolidone (PVPP), microcrystalline cellulose (MCC) and Povidone K30 (PVPK30)) were detected using the L9(34) orthogonal test to determine their effects...
September 2012
Volatiles in the Lysimachia clethroides Duby by head space solid phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS)
We studied for the first time, the volatile compounds in the Lysimachia clethroide Duby by using head space solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). The results showed that 14 compounds were identified from the stem of L. clethroides, 13 compounds were identified from the leaves, and 16 compounds from the flowers. 8 compounds were mutual components,...
September 2012
A randomized double-blind controlled study of the efficacy of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy
The objectives of this study are to compare the effectiveness of different proportions of ketamine and propofol in ketamine-propofol single-syringe combination (ketofol), and to compare the effectiveness of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy. Randomized, double-blind, controlled study of 100 female American Society of Anesthesiologists (ASA I or II) patients of age 18 to 40...
September 2012
Susceptibility to cardiac ischemia/reperfusion injury modulated by an estrogen derivative
Several studies indicate that some steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the effects of the estradiol derivatives on cardiac injury ischemia/reperfusion (I/R). Therefore, in this study, an estradiol derivative was synthetized with the objective of evaluating its activity on I/R in an ischemia-reperfusion model. In addition, molecular mechanism involved...
September 2012
Effect of Viola tricolor on pentobarbital-induced sleep in mice
Traditionally, Viola tricolor has been recommended for its sedative property. However, no pharmacological studies have yet evaluated the effect of this plant on sleep. The hydro-alcoholic extract (HAE) was prepared by the extraction of the aerial parts of V. tricolor in 70% ethanol using a Soxhalet apparatus. Also, with solvent-solvent extraction, the HAE was further fractionated to water...
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