African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2157

Table of Content: 8 April, 2012; 6(13)

April 2012

Pharmacological effects of two polar fractions from Annona coriacea Mart in animal models

In the current investigation, the antinociceptive and anti-inflammatory effects of the ethyl acetate and butanol fractions from Annona coriacea leaves were evaluated using standard experimental test models. The antinociceptive activity of A. coriacea was studied by acetic acid-induced writhing, formalin and hot-plate tests, and the anti-inflammatory activity was determined by carrageenan-induced...

Author(s): Orlando Vieira de Sousa, Glauciemar Del-Vechio-Vieira, Maria Silvana Alves, José de Jesus Ribeiro Gomes de Pinho, Célia Hitomi Yamamoto and Maria Auxiliadora Coelho Kaplan

April 2012

Hepatoprotective effect of Lysimachia paridiformis Franch. var. stenophylla Franch. on CCl4-induced acute liver injury in mice

As Chinese folklore medicine, Lysimachia paridiformis Franch. var. stenophylla Franch. (LPF) has been used for treatment of various diseases such as rheumatism and hemiplegia. Our previous studies have shown that LPF have strong antioxidant activity in vitro. Nevertheless, there have been no reports on the hepatoprotective effect of the extracts of LPF in animals. The aim of this study...

Author(s): Jin-feng Wei,, Yuan-yuan Li, Zhen-hua Yin, Fang Gong and Fu-de Shang

April 2012

Apoptotic effects of dehydroepiandrosterone sulphate (DHEAS) of the human promyelocytic leukemia cell (HL-60)

Dehydroepiandrosterone sulphate (DHEAS) has a protective role against cancer; however, the mechanism by which DHEAS has this effect remains poorly understood. The purpose of this study was to investigate the potential effects of DHEAS on HL-60 (human promyelocytic leukemia cell). The percentage of cells undergoing apoptosis was analyzed by flow cytometry using Annexin V-fluorescein isothiocyanate staining. DHEAS...

Author(s): Sema Uslu, Mehtap Kutlu, Eda Ozcelik and Arzu Iscan

April 2012

Proximate composition, antimicrobial and antioxidant activities of six wild edible celeries (Smyrnium L.)

In this study, proximate composition, antimicrobial and antioxidant activities of six Smyrniumtaxa, including, Smyrnium olusatrum, Smyrnium perfoliatum, Smyrnium rotundifolium,Smyrnium cordifolium, Smyrnium connatum and Smyrnium creticum (Umbelliferae) were determined. Antioxidant properties of methanol extracts were studied by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free...

Author(s): Ersin Minareci, Bülent Ergönül and Fatih Kalyoncu

April 2012

Study on the medicinal plant Calandula officinalis

The antibacterial and anti-fungal activities of the methanol and its sub fractions of chloroform, ethyl acetate, and water extracts of the roots, stem and leaves of Calendula officinalis were carried out against bacterial strains, Staphylococus aureus, Klebsiella pneumoniae, Salmonella typhymurium and Escherichia coli, and fungal species including Aspergilla fumigates, Fusarium...

Author(s): Iqbal Hussain, Jameel Ahmed Khader, Shumaila Noor, Riaz Ullah, Muhammad Talha, Badrullah and Majid Ahmed 

April 2012

Anti-Malassezia furfur activity of essential oils against causal agent of Pityriasis versicolor disease

Potential inhibitory effect of Citrus lemon (lemon) and Citrus sinensis (orange) on lipophilic, yeast like fungus Malassezia furfur which causes Pityriasis versicolor, chronic superficial fungal disease of the skin have been studied using two different methods: Disc diffusion and microdilution methods. In screening of lemon and orange oil by disc diffusion method, the diameter of...

Author(s): Richa  Sharma, Gajanand Sharma and Meenakshi Sharma

April 2012

High mobility group in A1a (HMGA1a) small interfering RNA (siRNA) blockage decreases metastatic potential in cultured osteosarcoma cell lines

High mobility group A1 (HMGA1) is a non-histone chromosomal nuclear protein that plays important roles on gene transcription, recombination, and chromatin structure stabilization. The aim of this study was to investigate the effect of small interfering RNA (siRNA) on HMGA1 expression and metastatic potential in osteosarcoma cell in vivo. We obtained osteosarcoma cell sublines after single cell cloning technique...

Author(s): Shaohui Yuan, Qi Pan, Chunjiang Fu and Zhenggang Bi

April 2012

Antinociceptive, antiinflammatory and antioxidant activities of ethanolic extract of Cancrinia discoidea (Ledeb.) Poljak

Antinociceptive, anti-inflammatory, and antioxidant activities of ethanolic extract of Cancrinia discoidea (Ledeb.) Poljak. (EEC) was evaluated. Intraperitoneal (IP) administration of EEC, in all the tested dose levels (100 to 300 mg/kg), exhibited significant dose-related inhibition of acetic acid-induced writhing and formalin induced nociception, exhibited significant dose-related inhibition of carrageenin...

Author(s): Si-Ming Zhu, Liang Zhu and Ying-Juan Tian

April 2012

Preparation of triptolide ethosomes

Filming-rehydration and ultrasonic method were combined to prepare ethosomes as a carrier of triptolide. A laser dynamic scattering instrument was used to determine the particle size of ethosomes. The average particle size was calculated based on the measurements of five different batches of ethosomes. To determine the entrapment efficiency, free triptolide was isolated by ultracentrifugation. The concentration of...

Author(s): Jin-Guang Chen, Yu Jiang and Zhi-bo Yang

April 2012

Testing willingness to pay for blood pressure measurement in community pharmacy

The Bulgarian primary healthcare system was faced by a number of challenges: The demands of an aging population, the growing strain on the primary healthcare services and a change in the daily activities of pharmacy and other primary healthcare professionals. These changes for community pharmacist are reflected more generally in contributing to accessible and efficient primary healthcare services, known as value-added...

Author(s): Evgeni E. Grigorov, Emilia K. Naseva, Hristina V. Lebanova and Ilko N. Getov

April 2012

Study on the anti-dementia and neural protection effects of ethamol soluble extract of Polygalae Radix

Polygalae radix, the root of Polygala tenuifolia Willd, has been widely used as a drug for the treatment of amnesia, calm, convulsions, aging, physical weakness, abnormal intelligence, etc, in traditional Chinese medicine. Recent research indicated that Polygalae radix has the function of neural protection. Extractions and fractionation of Polygalae radix were used as effective compounds in this research,...

Author(s): Gang Luo, Chang-qing Li, Wen-jie Zheng, Yue Zhou and Yunyi Yao

April 2012

Time dependent response in ghrelin levels in mesenteric ischemia in rat

The objective of this study was to determine the value of time-dependent ischemia-modified ghrelin in mesenteric ischemia. The authors investigated whether or not there is changes in plasma ghrelin levels in the acute period in a rat model of mesenteric ischemia were time-related. 42 mature male rats were divided into seven groups: one control and six ischemia groups. In the ischemia groups, following laparotomy the...

Author(s): Akgun Oral, Zekai Halici, Yasin Bayir, Emre Karakus, Sabri Selcuk Atamanalpand Yavuz Albayrak