African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 8 August, 2012; 6(29)

August 2012

Protective effect of tyrosol on apoptosis in PC12 cell induced by paraquat

The protective effect of tyrosol on apoptosis in PC12 cell induced by paraquat (PQ) was studied. The PC12 cell was cultured in RPMI-1640 medium supplemented with 10% newborn calf serum at 37°C in a 5% CO2 incubator. 800 μm of PQ solution was added to establish an oxidative-stress injury model in vitro. The protective effect of tyrosol was evaluated by using this model. We compared the lactate...

Author(s): Zhenxing Zhang, Xiaofeng Song, Xiaoyuan Du, Yu Cui and Jishou Dai

August 2012

Effect of extract of Urtica dioica on insulin and C-peptide secretion from rats (RIN5F) pancreatic beta cells

Plants are being used in the treatment of diabetes in traditional system of medicine. Urtica dioica (UD) has a variety of uses in traditional medicine. There are few reports about hypoglycemic mechanisms of U. dioica. The present study was designed to determine the possible mechanisms of hypoglycemic effects of UD on RIN5F rat pancreatic beta cells in vitromodels. Beta cells were prepared in multiple...

Author(s): Akbar Aliasgarzadeh, Majid Mobasseri, Amir Bahrami, Nosratollah Zargami and Ali Tabrizi

August 2012

A meta-analysis of the efficacy and safety of lacidipine in Chinese patients with mild to moderate essential hypertension

The purpose of this study was to evaluate the efficacy and safety of lacidipine tablets to treating Chinese patients with mild to moderate essential hypertension. We systematically searched the Cochrane central register of controlled trials (Issue 2, 2011), Medline (1966 to June 2011), EMbase (1966 to June 2011), CNKI (1993 to June 2011), WANFANG (1981 to June 2011), VIP (1989 to June 2011) and CBM (1991 to June 2011)...

Author(s): Xu Guo-liang, Du bing, Cao Hong-yan, Wu Hai-di and Qin Ling

August 2012

Impact of gender, weight and CYP2B6 genotype on efavirenz exposure in patients on HIV/AIDS and TB treatment: Implications for individualising therapy

Gender, weight and cytochrome P450 2B6 (CYP2B6) 516G>T genetic data of 61 patients on efavirenz containing highly active anti-retroviral therapy (HAART) was collated and analysed. Multivariate data analysis and correlations between variables were done to determine the relative contributions of gender, weight and CYP2B6 genetic polymorphism. Models were derived to guide dose adjustment in...

Author(s): Tafireyi Nemaura, Charles Nhachi and Collen Masimirembwa

August 2012

Comparative therapeutic potentials of acarbose and a formulated herbal extract on type 2 diabetic rats

Oxidative stress plays an important role in chronic complications of diabetes. Acarbose is an alpha-glucosidase inhibitor used for the treatment of diabetes. A commercial herbal formulated extract, which consists of 13 herbal extract (F13), is also described to have a potential antidiabetic action. The aim of this study was to determine the comparative effects of acarbose and F13 on type 2 diabetic rats. Three to five...

Author(s): Hulyam Kurt, Cansu Ozbayer, Irfan Degirmenci, Mehmet Cengiz Ustuner, Hilmi Ozden, Kismet Civi and Hasan Veysi Gunes

August 2012

Ferriprotoporphyrin IX-Combretum imberbe crude extracts interactions: Implication for malaria treatment

Leaves from Combretum imberbe traditionally used to treat symptoms of malaria in most parts of Southern Africa were studied for interaction of its crude methanolic, ethyl acetate and hexane extracts with hemin a product of hemoglobin degradation in 40% water-dimethylsulphoxide at pH 9, 7.4 and 5 using a spectrophotometric method. It has been established that hemin is the target of antimalaria quinolines thus,...

Author(s): P. Dzomba, T. Chayamiti, S. Nyoni, P. Munosiyei and I. Gwizangwe

August 2012

Effect of vitamin E and α-lipoic acid on nano zinc oxide induced renal cytotoxicity in Rats

The objective of this study is to detect toxic effects of two different doses of nano zinc oxide (ZnO-NP) particles. Moreover, a comparative study was conducted to modulate this toxic effect by the use of two natural antioxidants vitamin E (Vit E) and α-lipoic acid (α-Lip). The results of the current study revealed that ZnO-NP treatment produced hazard effects which were confirmed by the elevation of...

Author(s): Nouf Al Rasheed, Nayira A. Abdel Baky, Nawal Al Rasheed, Wedad Shebly, Aly Mohamed Ahmed and L. M. Faddah

August 2012

The effects of caffeine and carvedilol on skeletal system of rat embryos in prenatal period

Caffeine at high doses is a known rodent teratogen and induces limb malformations along with cleft palate in various strains of rats and mice. The teratogenic effects of some drugs can be prevented by the application of antioxidant drugs and stimulation of the maternal immune system. Also, there are some evidence that carvedilol is antioxidant. Therefore, in this study, the prophylactic effect of carvedilol on...

Author(s): Rashidi, F, Mahmood Khaksary Mahabady, Ranjbar  R and Najafzadeh Varzi  H

August 2012

Significance of the distribution of platelet-derived growth factor B chain in arteriosclerosis plaque in type-2 diabetic patients with arteriosclerosis obliterans of lower extremity

This study aims to explore the expression of platelet-derived growth factor (PDGF) in arteriosclerosis plaque on type 2 diabetes mellitus (DM) with arteriosclerosis obliterans (ASO) of the lower extremity. A total of 24 samples from 12 patients with lower-extremity ASO who underwent surgical treatment were collected in this study. Among these samples were 12 iliofemoral arterial plaques and 12 popliteal or distal...

Author(s): Xu Li, Long-Hua Fan, Jian-Jun Liu and De-Chun Xu

August 2012

Renoprotective effect of silymarin on gentamicin-induced nephropathy

Gentamicin (GM) is an aminoglycoside antibiotic which is used in clinical practice to treat severe gram-negative infections. Silybum marianum, also known as milk thistle, is a member of Asteraceae family and is well recognized as a hepatoprotective herbal medicine. The main objective of this present study was to evaluate the renoprotective effect of silymarin on GM-induced nephropathy. Eighteen healthy Ghezel...

Author(s): Mohammad Mashayekhi

August 2012

Unsupervised data mining technology based on research of stroke medication rules and discovery of prescription

For collecting and sorting literature on treatment of ancient and modern stroke at the entry point, frequency and charts analysis methods were applied. Modern computer technology and statistics were used to do in-depth study of stroke literature data, explore stroke differentiation of symptoms and signs and regular treatment by ancient physicians. On this basis, the unsupervised data mining technology was applied to...

Author(s): Xinjie Li, Mingqi Wang, Xujie Yu, Xiaoyan Li, Jingwei Liu, Zhenhua Jia, and Wei Cong