African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Table of Content: 8 July, 2013; 7(25)

July 2013

Developmental effects of extracts produced by some newly isolated Actinobacteria on the heart of Zebra fish (Danio rerio) embryos

Most actinomycete species have the capability to synthesize many different biologically active secondary metabolites such as antibiotics, herbicides, pesticides, anti-parasitic and enzyme inhibitors. The main focus of the present study was to isolate some new actinobacterial strains from the Saudi habitats and study the biological effects of their secondary metabolites on the heart development of the zebra fish embryos...

Author(s): Wael N. Hozzein, Muhammad Farooq, Adel H. Al-Malki and Mohammed A.M. Wadaan

July 2013

Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan

Aqueous and hydro-alcoholic extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan were screened for their antioxidant, antibacterial and antiplatelet efficacy. Total phenols and flavonoids were determined colorimetrically. The radical scavenging activities were evaluated using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical...

Author(s): Hana M. Hammad, Camelia Albu, Suzan A. Matar, Simona-Carmen Litescu, Hala I. Al Jaber, Amal S. Abualraghib and Fatma U. Afifi

July 2013

Nutritional composition, vitamins, minerals and toxic heavy metals analysis of Digera muricata (L.) Mart.: A wild edible plant from Peshawar, Pakistan

This study was aimed to assess the nutritional potential of an unexplored wild edible plant,Digera muricata (L.) Mart. commonly used as food in Peshawar, Khyber Pakhtunkhwa, Pakistan. The nutritional, vitamins, minerals and trace elements were investigated, using standard methods of Association of Official Analytical Chemists (AOAC). Nutritional assessment included determination of moisture, ash, lipid, fiber,...

Author(s): Naeem Khan, Naima Tahir, Alia Sultana, Iqbal Hussain, In Min Hwang, and Kyong Su Kim

July 2013

Effect of Ocimum basilicum on ovary tissue histopathology after exposure to electromagnetic fields (EMF) in rats

Plants continue to be a major source of medicines, as they have been throughout human history. Ocillium basilicum has been used since ancient times as a medicine and food and it is known that the antioxidant effect of O. basilicum is beneficial to protect tissue and decreasing carcinogeniceffect of electromagnetic field (EMF), so it was hypothesized that this herb might also provide protection to...

Author(s): Arash Khaki, Amir Afshin Khaki, Amir Ezzatzadeh, and Hamidreza A-Ashteani

July 2013

Formulation of solid dispersion and surface solid dispersion of nifedipine: A comparative study

In this study, an attempt was taken to enhance the solubility and dissolution characteristics of nifedipine, a poorly water soluble calcium channel blocking agent, by preparing solid dispersions (SD) with water soluble carriers; Poloxamer 407, HPMC 5 cPs, polyethylene glycol (PEG) 4000 and 6000 and surface solid dispersions (SSD) with insoluble carriers; sodium starch glycolate (SSG) and croscarmellose sodium...

Author(s): Anjuman Ara Alam, Md. Abdullah Al Masum, Rezaur Bin Islam, Florida Sharmin and S. M. Ashraful Islam

July 2013

In vitro antimicrobial activity of Syzygium cumini fruit peel and identification of anthocyanins

The present investigation evaluated the antimicrobial potential of Syzygium cumini (SC) fruit peel against fourteen microorganisms and identified major anthocyanins. Methanol, ethyl acetate and dichloromethane extracts of shade dried SC fruit peel were screened for antimicrobial effects using disc diffusion and minimum inhibitory concentration (MIC) methods. Methanol extract showed maximum antimicrobial...

Author(s): Sathyan Sri Lavvanya Priya, Ponnusamy Renuka Devi, Palanisami Eganathan and Jayasurya Kingsley

July 2013

Oestrogenic properties of the ethanolic extract of Fernandoa adolfi friderici (Bignoniaceae) stem bark

Fernandoa adolfi friderici is used traditionally to treat menopause related symptoms. The effects of the ethanolic extract of this plant in ovariectomized (OVX) rats were investigated. 40 of 50 rats were OVX and separated into four groups of 10 each. 84 days after ovariectomy, animal groups were started on one of four treatments: ethanol/0.09% NaCl (control group), oestrogen, extracts of F. adolfi...

Author(s): Dieudonné Njamen, Benedicta N. Nkeh-Chungag, Marie A. Mvondo and N. S. Tchoukouegno

July 2013

Antihyperlipidemic effect of ambrex, a polyherbal formulation against experimentally induced hypercholesterolemia in rats

Ambrex, a polyherbal formulation was tested for its antihypercholesterolemic effect against experimentally induced hypercholesterolemia in rats. Alteration in the levels of serum marker enzymes, alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and general biochemical parameters glucose, protein, urea and creatinine were tested in both treated and...

Author(s): Jamuna Devi and Johanna Rajkumar

July 2013

Novel controlled release of antihypertensive drug: preparation, in-vitro and in-vivo evaluation

The objective was to control the release of diltiazem HCl. Emulsion solvent evaporation technique was applied to encapsulate diltiazem HCl using ethyl cellulose or Eudragit RS100. The prepared microspheres were characterized concerning entrapment efficiency;micromeritics properties and surface morphology using SEM and mixed with carbopol, hydroxypropyl methyl cellulose, or chitosan in different ratios....

Author(s): Khalid M. El-Say, Abdel-Rahim M. El-Helw, Osama A.A. Ahmed, Khaled M. Hosny, Tarek A. Ahmed,

July 2013

Preventive effects of silymarin in retinal intoxication with methanol in rat: Transmission electron microscope study

The aim of this study was to investigate the ultra-structure of the photoreceptor layer of male rats under the effect of methanol intoxication and protective effect of silymarin against the methanol toxicity. Fifteen adult male rats were divided into three groups: Control group, Experimental group I (received 4g/kg methanol by intraperitoneal injection for five days), Experimental group II (received 4 g/kg methanol by...

Author(s): Ali Zarenezhad, Arash Esfandiari and Ali Aliabadi

July 2013

Influence of serpentine soils on the flavonoid content of Hypericum populations growing in Bulgaria

The effect of environmental factors on the production of secondary metabolites by plants has attracted a considerable amount of attention. Most species populations growing on serpentine soils are adapted to these special edaphic conditions in different ways. In this study we investigated the flavonoid content in Bulgarian Hypericum populations from five Hypericumspecies (H. cerastoides, H....

Author(s): Ilina Krasteva, Anely Nedelcheva, Dolja Pavlova, Petranka Zdraveva, Stefan Nikolov and Konstantin Mitov