African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 8 November, 2011; 5(17)

November 2011

A review on Hyssopus officinalis L.: Composition and biological activities

Hyssopus officinalis L. (Hyssop) is one of the most popular herbal preparations, mainly distributed in the East Mediterranean to central Asia. The plant has been used traditionally for medicinal purposes; generally, these therapeutic uses and health benefits of hyssop are largely based on folklore rather than on scientific substantiation, making it a good candidate to gather documentations, including the...

Author(s): Fatemeh Fathiazad and Sanaz Hamedeyazdan

November 2011

Identification of phenolic compounds and assessment of in vitro antioxidants activity of 30% ethanolic extracts derived from two Phyllanthus species indigenous to Malaysia

Phenolic compounds were identified in 30% ethanolic extracts derived from Phyllanthus niruri(P. niruri) and Phyllanthus urinaria (P. urinaria) using high performance liquid chromatography (HPLC) assay. In vitro antioxidants activity of the extracts was studied based on total phenolic contents (TPC) using Folin-Ciocalteu reagent and their scavenging activity towards radical...

Author(s): Elrashid Saleh Mahdi, Azmin Mohd Noor, Mohamed Hameem Sakeena, Ghassan Z. Abdullah,  Muthanna Abdulkarim and Munavvar Abdul Sattar

November 2011

Cultural importance and antibacterial activity of Ziziphus mucronata (Willd.) in the Umlazi community in Durban

The Zulu community of Umlazi, Durban makes extensive use of Ziziphus mucronata (Buffalo thorn) for predominantly cultural purposes. There are many superstitions and beliefs associated with the tree. A validation of its antimicrobial properties from leaf, bark and root extracts were attempted against three Gram positive and three Gram negative bacteria. In addition, an antifungal assay was attempted, using...

Author(s): R. M. Coopoosamy, K. K. Naidoo and N. J. Ndlazi

November 2011

Altitude-related changes in activities of carbon metabolism enzymes and secondary plant products-menthoforon an active pharmaceutical constituents yield in pippermint (Mentha piperita L. Var. Kukarail)

Activities of some enzymes related to carbon metabolism were studied in different ecotypes of pippermint (Mentha piperita L. Var. Kukarail), growing at 950 and 1,250 m above mean sea level. Activities of peroxidase and superoxide dismutase (SOD) and geranyl pyro phosphate (GPP) are significantly higher in higher altitude cultivated cultivars. The GPP which converts to geranyl geranyl pyro phosphate (GGPP)...

Author(s): A. Misra and N. K. Srivastava

November 2011

Simultaneous determination of gatifloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations by HPLC

A liquid chromatography method was developed and validated for the simultaneous determination of gatifloxacin and dexamethasone sodium phosphate in bulk and pharmaceutical formulations. Optimum separation was achieved in less than 5 min using a C18column (250 × 4.6 mm i.d, 5 µ particle size) by isocratic elution. UV detection was carried out at 254 nm. Developed method was economical in terms of the time...

Author(s): K. R. Sireesha and K. Prakash

November 2011

Anti-inflammatory and wound healing activity of Fagonia schweinfurthii alcoholic extract herbal gel on albino rats

Traditionally, a large number of plants are used for treatment of inflammation and wounds. In Asian and African countries Fagonia schweinfurthii (Hadidi) (F. Zygophyllaceae) and the closely related herb, such as Fagonia arabica are traditionally used for treatment of inflammation, open wounds, boils, skin eruptions, allergies, etc. Hence, the present study was conducted to investigate the...

Author(s): Saleh I. Alqasoumi, Hasan S. Yusufoglu and  Aftab Alam

November 2011

The effects of maximal aerobic exercise on cortisol and thyroid hormones in male field hockey players

Some metabolic and endocrine functions might be influenced by exercise and it leads to changed concentrations of hormone secretions in humans. In order to determine the changes of thyroid hormones (THs) related to shuttle run exercise (SRE),  14 field hockey players and their thyroid stimulating hormones (TSH) free T3 (fT3), free T4 (fT4) were included in this study, and cortisol levels were measured...

Author(s): Malik BEYLEROGLU

November 2011

Cationic liposomes as gene delivery system

Delivery of oligonucleotides (ONs) and genes to their intracellular targets is a prerequisite for their successful use in medical therapy. Cationic liposomes are among the most commonly used and promising delivery system for ONs and genes. Cationic-liposomes and their complexes with ON were characterized according to complex size, zeta potential measurements, transmission electron microscope (TEM) and confocal laser...

Author(s): Mohsen M. Mady

November 2011

Nitrous oxide versus pethidine with promethasine for reducing labor pain

Systemic opioids are widely used for the relief of labor pain. Self-administered nitrous oxide with concentration of 50% is a new form of analgesia. The aim of this study was to compare the analgesic efficacy and side effects of the patient controlled inhaled nitrous oxide (50% ‘‘Entonox’’) with systemic intramuscular pethidine, in reducing pain during normal vaginal labor in Iranian population....

Author(s): Batool Teimoori, Nahid Sakhavar, Masoome Mirteimoori and Behzad Narouie

November 2011

Differential analysis of human kidney stone samples using electrospray ionization mass spectrometry

Kidney stones may be caused by many factors, including ingestion of melamine for a relatively long time. The diagnosis of melamine-induced kidney stones and the understanding of how the melamine is involved in the formation of kidney stones are of practical importance. To establish a sensitive method based on widely used electrospray ionization mass spectrometry (ESI-MS) for diagnosis of melamine-induced kidney stones...

Author(s): Zhiquan Zhou, Yongzhong Ouyang, Xiangtai Zeng, Tingting Zhang, Bin Jia, Xinglei Zhang, Huanwen Chen and Jianhua Ding 

November 2011

Radical scavenging and antioxidant activity of Hibiscus rosasinensis extract

Free radicals induce numerous diseases by lipid peroxidation, protein peroxidation and DNA damage. It has been reported that numerous plant extracts have antioxidant activities to scavenge free radicals. In the present study, the antioxidant properties of crude extract ofHibiscus rosasinensis were examined, using different in vitro analytical methodologies, such as total antioxidant activity determination...

Author(s): Rajesh Mandade, S. A. Sreenivas, D. M. Sakarkar and Avijit Choudhury

November 2011

Therapeutic monitoring of isoniazid, rifampicin, ethambutol and pyrazinamide serum levels in the treatment of active pulmonary tuberculosis and determinants of their serum concentrations

Inadequate serum levels of antimycobacterial drugs have been associated with treatment failure, relapse and acquired drug resistance as well as high concentrations of these drugs may cause intolerance and toxic effects. We objected in this study to determine serum concentrations of anti-tuberculosis drugs and to know the determinants of their concentrations. Venous blood samples was obtained 2 and 6 h after drug...

Author(s): Servet Kayhan, and Alper Akgüneş,