African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2237

Table of Content: August 2011; 5(8)

August 2011

Evaluation of the effects of ciprofloxcin or gatifloxacin on neurotransmitters levels in rat cortex and hippocampus

The objective of the present work is to study the possible role of neurotransmitters in the central nervous system (CNS) side effects due to the administration of ciprofloxacin (80 mg/kg body weight) and gatifloxacin (32 mg/kg body weight) in male albino rats for 3, 7 and 14 days. The frontal cortex of ciprofloxacin and gatifloxacin treated groups revealed decrease of glutamate,...

Author(s): Sayed M. Rawi, Nadia M. S. Arafa and Mansour M. El-Hazmi

August 2011

Evaluation of estrogen-like activity of Nigella sativa in ovariectomized rats

The purpose of the current study was to evaluate estrogenic activity of Nigella sativausing ovariectomized (OVX) rats. Forty OVX rats divided into five groups. N. sativawas administered orally as a supplement to chaw palate at different doses of 300, 600 and 1200 mg/kg for 21 days to OVX rats and were compared to either positive (0.2 mg/kg conjugated equine estrogen- CEE) or negative control (1 ml distilled...

Author(s): Saadat Parhizkar⊃,⊃, Latiffah Abdul Latiff, Sabariah Abdul Rahman, and Mohammad Aziz Dollah

August 2011

Reducing queues in a Nigerian hospital pharmacy

Queues are characterized structures formed to maintain order and create a hold on time, money and human contribution towards development and efficient performance of any system. The aim of this work was to characterize the queue, describe the queue discipline of the outpatient pharmacy, to institute a cross-sectional intervention by streamlining queue behaviour and to measure the impact of streamlining queue...

Author(s): Ndukwe H. C., Omale S. and Opanuga O. O.

August 2011

A meta-analysis of the efficacy and safety of candesartan in Chinese patients with mild to moderate essential hypertension

This study was performed to evaluate the efficacy and safety of Candesartan in treating Chinese patients with mild to moderate essential hypertension. Medical databases and review articles were screened with prespecified criteria for randomized controlled trials that reported the effects of and adverse reactions to Candesartan and other antihypertensive drugs in treating of Chinese patients with mild to moderate...

Author(s): Cui Wen-peng, Du Bing and Qin Ling

August 2011

The effect of gallic acid on kidney and liver after experimental renal ischemia/reperfusion injury in the rats

To investigate the effect of gallic acid (GA) on kidney and liver against oxidative stress during renal ischemia-reperfusion (I/R) injury, by determining biochemical parameters and evaluating histological examinations.   Key words: Gallic acid, ischemia-reperfusion, kidney, liver, antioxidant enzyme

Author(s): Mediha Canbek, Mehmet Cengiz Ustüner, Sahin Kabay, Onur Uysal, Hilmi Ozden, Gökhan BayramoÄŸlu, Hakan Sentürk, Cansu Ozbayar, Aysegül Bayramoglu, Derya Ustüner and Irfan Degirmenci

August 2011

Effect of roasting, boiling and microwaving cooking method on doxycline residues in edible tissues of poultry by microbial method

The purpose of this study was to determine the effects of different cooking processes like boiling, roasting and microwaving on doxycline residues in chicken muscle, liver and gizzard tissues of broiler chickens. Each chick was fed by water and food with 0.1% of Doxycline in their drinking water for 5 consecutive days. Then, three locations were sampled aseptically from each carcass: Breast muscle, liver and...

Author(s): Javadi A.

August 2011

Anti atherosclerotic effects of verjuice on hypocholesterolemic rabbits

1Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran. 2Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 4Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 5Department of...

Author(s): Mahbubeh Setorki, Bahar Nazari, Sedighe Asgary, Leila Azadbakht, and Mahmoud Rafieian-Kopaei

August 2011

Purified alkaloid extract of Scutellaria barbata inhibits proliferation of hepatoma HepG-2 cells by inducing apoptosis and cell cycle arrest at G2/M phase

Scutellaria barbata was widely used as an antitumor agent in traditional Chinese medicine. However, its antitumor components and mechanism remained unclear. In the present study, the effects of purified alkaloid extract of Scutellaria barbata (PAESB) on the cultured hepatoma HepG-2 cells were investigated. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay showed that PAESB could...

Author(s): Tie-shan Wang,#, Li-jing Chen#, Zhao-yu Wang#, Sheng-tan Zhang and Jing-ming Lin

August 2011

Development of novel herbal cosmetic cream with Curcuma longa extract loaded transfersomes for antiwrinkle effect

Curcuminoids obtained from Curcuma longa have properties like photoprotection, antiaging, anti- wrinkle, moisturizing, antioxidant, astringent, anti-irritant, antimicrobial and anti-inflammatory activities. Our aim was to develop a stable nano-transfersomes loaded cream which could correct the morphological defects and penetrate deeper to the cellular level of dermis to produce anti-wrinkle effect. Soxhlet...

Author(s): Swarnlata Saraf, Gunjan Jeswani, Chanchal Deep Kaur and Shailendra Saraf

August 2011

Preparation of ambroxol hydrochloride carboxymethyl chitosan micropheres without burst release

The aim of this article was to fabricate novel ambroxol hydrochloride carboxymethyl chitosan microspheres without burst release. Firstly the blank carboxymethyl chitosan microspheres were fabricated by the emulsion chemical cross-linking method and the blank microspheres showed a controllable biodegradation in vitro in lysozyme solution. Then the ambroxol hydrochloride microspheres were prepared by the column...

Author(s): Hongfei Liu, Yan He, Zhaoying and Peng Ke

August 2011

Effect of absorption enhancers on nasal delivery of basic fibroblast growth factor

The present study was to screen an optimal absorption enhancer for enhancing the nasal absorption of basic fibroblast growth factor (bFGF), a promising therapeutic agent to neurodegenerative diseases. In this study, four absorption enhancers including chitosan, sodium caprate, poly-L-arginine (poly-L-Arg, 92.0 kDa) and dimethyl-β-cyclodextrin were chosen to evaluate their toxicity using in situ toad palate model...

Author(s): Feng Chengcheng, Shao Xiayan, Zhang Chi, Liu Qingfeng, Chen Jie, Shen Yehong, Zhang Qizhi and Jiang Xinguo

August 2011

Modulation of monoamines and amino-acids neurotransmitters in cerebral cortex and hippocampus of female senile rats by ginger and lipoic acid

Brain aging is the major risk factor for common neurodegenerative diseases. Free radicals are involved in neurodegenerative disorders such as aging. Several neural systems are affected in aging. Neurotransmitters exhibited a marked alteration in different regions of the brain as part of the normal aging process. In the present study, age-related changes in the levels of monoamines and amino-acids neurotransmitters in...

Author(s): Hoda G. Hegazy and Elham H. A. Ali

August 2011

Induction of apoptosis by Rhizoma Paridis saponins in MCF-7 human breast cancer cells

This study investigates the relationship between the induction of MCF-7 human breast cancer cell apoptosis by Rhizoma Paridis saponins (RPS) and the mitochondrial apoptotic pathway. We treated MCF-7 cells with RPS at various concentrations and examined the inhibitory effect of RPS on the proliferation of MCF-7 cells using the 4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the change in...

Author(s): Chuan Lu†, ChunJiang Li,†, Dongmei Wu, JingMei Lu, Fan Tu, Lijuan Wang

August 2011

In-vivo study of stratum corneum water content and transepideramal water loss using a newly formulated topical cream of hippophae rhamnoides fruit extract

This study was purposed to determine the effects of newly formulated topical skin-care cream (w/o emulsion) of Hippophae rhmanoides versus its vehicle (Base) as control on stratum corneum (SC) water content and transepidermal water loss (TEWL). Concentrated H. rhamnoids (sea Buckthorn) fruit extract was entrapped in the inner aqueous phase w/o emulsion. Newly formulated and previously evaluated base...

Author(s): Barkat Ali Khan, Naveed Akhtar, Tariq Mahmood, Haji M. Shoaib Khan, Shahiq-Uz-    Zaman, Akhtar Rasul, Muhammad Iqbal, Atif Ali, Salimullah Khan and Mughal Qayum

August 2011

Ameliorative effects of ginger and α-lipoic acid on oxidative stress and inflammation in senile female rats

Oxidative stress is recognized as an important environmental factor in aging. The reactive oxygen species and related free radicals are normally produced both intra and extracellular and air-breathing organisms cannot avoid the risk of oxidative stress. Moreover, recent studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In the present study, the...

Author(s): Hoda G. Hegazy

August 2011

Modeling a murine model of immunoglobulin-E (IgE)-mediated qingkailing injection anaphylaxis

Qingkailing injection (QKLI) is a classic compound traditional Chinese medical injection (TCMI). It can cause anaphylatic shock and death in clinic. Modeling a murine model of qingkailing injection anaphylaxis appears to be essential. In this study, for the first time, we used several strategies to prepare cationic bovine serum albumin (cBSA) and QKLI-cBSA conjugate. The native bovine serum albumin (nBSA), cBSA and...

Author(s): Guoping Liao, Wenshi Li, Shuai He and Zhongyi Zhang

August 2011

Comparison of the effect of acupressure, fish oil capsules and ibuprofen on treatment of primary dysmenorrheal

Primary dysmenorrhea is one of the common causes of absence from workplace and decline in the quality of life of women. Because of the importance and prevalence of dysmenorrhea among women and girls of childbearing age, and due to the publication of reports concerning the effectiveness of fish oil and acupressure in curing primary dysmenorrhea, this study was conducted with the purpose of comparing the effectiveness of...

Author(s): Zafari, M., Tofighi, M., Aghamohammady, A., Behmanesh, F. and Rakhshaee, Z.

August 2011

The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies

n-butanol extract (n-Bt ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic acid induced writhing and hot plate tests. The extract exhibited significant antinociceptive activity (P<0.01) in these tests. Standard centrally acting analgesic, morphine, peripherally acting and diclofenac were also tested along with the extract for comparison. The antinociceptive...

Author(s): Abbas M, Subhan F, Mohani N, Rauf K, Ali G and Khan M

August 2011

Synergy of daptomycin with fusidin against invasive systemic infection and septic arthritis induced by type IV group B streptococci in mice

In view of the emergence of multidrug-resistant group B streptococci (GBS), and its significant clinical impact, there is a necessary need for the development of more effective therapeutic alternatives. Here, we assessed the therapeutic efficacy of daptomycin, a novel lipopeptide antibiotic, in the treatment of type IV GBS-induced invasive systemic infection and septic arthritis in mice. We also evaluated the...

Author(s): Adel Galal El-Shemi, and Hani S. Faidah

August 2011

Anti-nociceptive, anxiolytic and anticonvulsant effects of an aqueous leaf extract of Leea guineensis G. Don (Family: Leeaceae)

Leea guineensis G. Don (Family: Leeaceae) is an evergreen shrub or small tree used in Ghanaian traditional medicine to treat various ailments including epileptic fits and pain. However, little scientific evidence exists to support its use. The present study examined the anti-nociceptive, anti-anxiety and anticonvulsant effects of the aqueous leaf extract of L. guineensis (LGE) in murine models of pain...

Author(s): Eric Woode, David Abasiwani Alagpulinsa and Wonder Kofi Mensah Abotsi

August 2011

HI-6 and obidoxime implication in oxidative stress, antioxidants level and apoptosis

The oxime reactivators, obidoxime and asoxime (HI-6) are suitable for antidotal treatment after exposure to nerve agents. Although they are considered for use in humans under emergency situations, complete clinical studies are lacking as there were no clinical trials. We examined obidoxime and HI-6 in laboratory rats intramuscularly exposed to 25% of the median lethal dose (210 and 780 mg/kg) of each oxime reactivator...

Author(s): Miroslav Pohanka, Ladislav Novotny, Josef Fusek and Jiri Pikula

August 2011

Triterpenoids from Vernonia auriculifera Hiern exhibit antimicrobial activity

Phytochemical investigation of Vernonia auriculifera afforded farnesylamine, a sesquiterpene amine that has not been found previously in plant species, together with lupenyl acetate, oleanolic acid, β-amyrin acetate, β-amyrin, friedelanone, friedelin acetate, α-amyrin and β-sitosterol. The compounds were characterized using nuclear magnetic resonace (NMR) spectroscopy and comparison with...

Author(s): Joyce Jepkorir Kiplimo, Neil Anthony Koorbanally and Hafizah Chenia

August 2011

Nutritional and elemental analyses of some selected fodder species used in traditional medicine

The present study was carried out to evaluate the nutritional value and elemental analysis of some fodder plant species. Proximate composition of proteins, crude fibers, fats and oils, moisture, ash contents and carbohydrates and elemental composition of aerial parts have been determined by using Atomic Absorption Spectrophotometer (AAS). A total of 16 elements; Na, Mg, Al, Si, P, S, Rb, K, Ca, Fe, Mn, Ti, Ni, Cu, Zn...

Author(s): Ali Bahadur, Zubeda Chaudhry, Gul Jan, Mohammad Danish, Atta ur Rehman, Rafiq Ahmad, Aman khan, Shah Khalid, Irfan ullah, Zahir Shah, Farman Ali, Tahira Mushtaq and Farzana Gul Jan

August 2011

Acute toxicity and anti inflammatory effects of supercritical extracts of Ilex paraguariensis

This work reports the in vivo evaluation of acute toxicity and anti-inflammatory activity of supercritical carbon dioxide (CO2) extracts of Ilex paraguariensis. For the acute toxicity study, the extracts diluted in sunflower oil were administered to adult male wistar rats in single doses of 250 mg/kg by the intraperitoneal route. Adverse effects and mortality were monitored along 14 days. In the case of...

Author(s): Tiago R. Pasquali, Sandra M. D. Macedo, Silvane S. Roman, Valéria Dal Prá, Rogério L. Cansian, Altemir J. Mossi, Vladimir J. Oliveira and  Marcio A. Mazutti

August 2011

Evaluation of the stem bark of Pistacia integerrima Stew ex Brandis for its antimicrobial and phytotoxic activities

The antimicrobial and phytotoxic activities of the crude methanolic extract and its subsequent solvent fractions of Pistacia integerrima bark were investigated. The outstanding activity was shown by the ethyl acetate fraction followed by aqueous fraction against Staphylococcus aureus having zone of inhibition 19 and 15 mm respectively. The ethyl acetate fraction was also effective...

Author(s): Shafiq ur Rahman, Muhammad Ismail, Naveed Muhammad, Farhat Ali, Kamran Ahmad Chishti and Muhammad Imran

August 2011

Antioxidant and antibacterial activity of crude methanolic extract of Euphorbia prostrata collected from District Bannu (Pakistan)

Medicinal plants help in improving the human health that is primarily due to bioactive constituents such as flavonoids, alkaloids, saponins, cardiac glycosides and tannins. These compounds play important role in minimizing oxidative stress, cancer, impotency, cardiac dysfunction and microbial inhibition. Euphorbia prostrata (L) is a small prostrate, annual herb found all over the world including...

Author(s): Mushtaq Ahmad, Abdus Saboor shah, Rahmat Ali Khan, Farid Ullaha Khan, Noor Aslam Khan, Mir Sadiq Shah and Muhammad Rashid Khan

August 2011

Development of new spectrophotometric determination of titanium in homeopathic pharmacy using Ponceau S as a reagent

Spectrophotometric method has been developed for the determination of titanium (III). The linear calibration curve was obtained with 2-10 μg/ml titanium. The titanium was determined in pharmaceutical preparation with coefficient of variation 3.0%. The concentration of titanium was calculated from the standard calibration curve and was found 111.25 µg/ml with coefficient of variation 3.0%. The obtained...

Author(s): G. M. Mastoi, M. Y. Khuhawar, Kulsoom Abbasi, Moina Akhtar, Saba Naz, Humaira Khan, Arfana Mallah and Zuhra Memon