African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2152

Table of Content: July 2010; 4(7)

July 2010

Tripterine induces apoptosis of human acute myelocytic leukemic cells via up-regulating Fas/FasL and down-regulating NF-κB

This study investigated the mechanism underlying the effect of tripterine on apoptosis of human acute myelocytic leukemic cells (HL-60). The apoptosis of HL-60 cells after treatment with triperine of different dosages and durations were determined using flow cytometry and transmission electron microscopy. The expressions of Fas, FasL and NF-κB in the HL-60 cells treated with 1.5 μmol/L tripterine for different...

Author(s): Sheng Quan, Yin-Hai Xu, Xiao-Ping Xia, Jin-Fang Zhao and Jie Yan

  • Article Number: 9EA6CD829399

July 2010

A study of Nigella sativa oil in the management of wheeze associated lower respiratory tract illness in children

Nigella sativa seeds and its oil had been widely used in traditional medicine (particularly in Unani Medicine) for a wide variety of illnesses including bronchial asthma in adults. The adjuvant effect of N. sativa oil in patients of bronchial asthma has already been reported but, no work had yet been done in very common disease of children called wheeze associated lower respiratory tract illness (wheeze...

Author(s): Jameel Ahmad, Rahat Ali Khan and M. Ashraf Malik

  • Article Number: 1BCF58229428

July 2010

Effects of anti-CD25 monoclonal antibody on the corneal allograft rejection in a rat model

This study aims to investigate the effects of anti-CD25 monoclonal antibody (mAb) on the effector T cells (Teff) and CD4+CD25+ regulatory T cells (CD4+CD25+Treg) in corneal allograft rejection. Wistar rats were used as donors and SD rats were used as recipients. Routine penetrating keratoplasty (PKP) was performed. 90 SD rats were randomly divided into 5 groups: A - E. Group A (n = 6) was normal group and rats in...

Author(s): Yu-Bo Gong, Xiao-He Lu , Jin Zhou, Wei Yuan and Yi-Fei Huang

  • Article Number: 557EE0929457

July 2010

The effects of short-term exercise on the parameters of oxidant and antioxidant system in handball players

The aim of the study was to evaluate the effects of short-term exercise on total antioxidant capacity (TAC), lipid hydroperoxide (LOOHs), total oxidative status (TOS) and oxidative stress index (OSI) in handball players. A total of 20 amateur handball players participated in the study. Handball players were training regularly 3 days a week for 2 h. All subjects followed a circuit exercise program. Blood samples...

Author(s): Recep Kurkcu

  • Article Number: 44C01A229472

July 2010

Effects of advanced glycation end products on expressions of EMMPRIN and MMP-2 in mouse osteoblasts

This study investigated the effects of advanced glycation end products (AGEs) on expressions of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-2 (MMP-2) in mouse osteoblasts. MC3T3-E1 cells were incubated with AGEs of different concentrations (50, 100, 200 and 400 mg/L) for various durations (12, 24 and 48 h). The expressions of EMMPRIN mRNA and protein as well as MMP-2 expression...

Author(s): Rongfeng Dai, Li Wang, Hui Jin and Zilin Sun

  • Article Number: DF68B4029511

July 2010

Heavy metal concentrations in plants growing in crude oil contaminated soil in Akwa Ibom State, South-Eastern Nigeria

A field study was conducted to assess heavy metal concentrations in plants grown on crude oil contaminated soil in Akwa Ibom State. Plant samples obtained from polluted and unpolluted (control) sites were digested and analysed for manganese (Mn), iron (Fe), lithium (Li), zinc (Zn), copper (Cu), cadmium (Cd), chromium (Cr), lead (Pb), cobalt (Co), vanadium (V), molybdenum (Mo), mercury (Hg) and selenium (Se). The...

Author(s): U. A. Essiett, G. S. Effiong, F. O. Ogbemudia and E. J. Bruno

  • Article Number: FFFD70529538

July 2010

The protective effects of Cordyceps sinensis extract on extracellular matrix accumulation of glomerular sclerosis in rats

The objective of the present study is to observe protective effects of Cordyceps sinensis extract on extracellular matrix (ECM) accumulation and explore its therapeutic mechanism. The glomerular sclerosis model was established by unilateral nephrectomy and injecting adriamycin. Then urinary protein, BUN and Scr levels were measured. Renal pathological changes were observed by light microscopy....

Author(s): Li-Qun Song, Yu Si-Ming, Ma Xiao-Peng and Jin Li-Xia

  • Article Number: C75D25529563

July 2010

The effects of pyrimethamine sulfadoxine and berenil on glucose-6-phosphate dehydrogenase activity in Trypanosoma brucei brucei and Trypanosoma brucei congolese infected rats

The effects of pyrimethamine sulfadoxine (PS) and Berenil on the glucose 6-phosphate dehydrogenase  (G6PD) activity in the blood, brain, heart, kidney, liver and skeletal muscle tissues of Trypanosoma brucei bruccei (Tbb) andTrypanosoma brucei congolense (Tbc) infected Wistar rats were investigated. Forty-eight rats with a mean weight of 140.0 g were divided into 2 equal groups and separately treated...

Author(s): C. L. Coleshowers, O. O. Oguntibeju, Q. M. Etoh, C. O. Alebiosu and E. J. Truter

  • Article Number: D9924D629587

July 2010

Comparison of the effectiveness of vitamin C vaginal tablet with metronidazole vaginal gel in the treatment of bacterial vaginosis

Bacterial vaginosis is a change of vaginal flora in which the normal lactobacilli florais replaced by an overgrowth of Gardnerella vaginalis and anaerobic bacteria. Bacterial vaginosis is the most common cause of vaginal infection in women during their reproductive age. The relationship between bacterial vaginosis and increase of vaginal pH is suggested by the use of intravaginal acidification substances...

Author(s): Abbaspoor Zahra, Goodarzy Fateme and Abbaspoor MohamadReza

  • Article Number: 0ADD8C829615

July 2010

Integron-plasmid mediated antibiotic resistance and virulence factors in clinical Salmonella enterica serovars in rural Western Kenya

Integron-mediated antibiotic resistance is common among diverse Salmonellaserovars. Phenotypic antibiotic resistance was correlated with the presence of intergron–mediated genes in 65 Salmonella typhimurium isolates using conventional microbiological methods and PCR gene amplification. The resistance genes detected in the 20 S. typhimurium isolates were mainly those identified as part of...

Author(s): David Miruka Onyango, Rose Kakai, Waindi Eliud Nyandago, B. Ghebremedhin, W. Konig and B. Kong

  • Article Number: 1C258A729640

July 2010

Effect of heat moisture treatment on the functional and tabletting properties of corn starch

The effect of heat moisture treatment on the functional and tabletting properties of corn starch BP was investigated. Corn starch was hydrothermally modified by heat moisture treatment (HMT) at 100oC, 16 h; 20% moisture level (HIC – 20), 25% moisture level (HIC – 25), and 30% moisture level (HIC – 30). The tablet formation properties were investigated using Heckel and Kawakita equation, while its...

Author(s): Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria. Department of Chemistry, University of Ado-Ekiti, Ado-Ekiti, Ekiti State, Nigeria.