May 2020

Chemical characterization of seeds of Amazon fruits as nutritional contribution with functional medicinal potential

The fruit seeds of the Northern Amazon Region were evaluated bromatologically and nutritionally in terms of the level of macro- and micro-elements and fatty acids present in them. Bromatologically, the seeds of camu-camu (369.08 kcal 100 g-1) and biribá (364.78 kcal 100 g-1) have the highest energy value. In terms of the macroelements, the highest concentration was potassium (554.23 mg 100 g-1) seen in graviola,...

Author(s): Ismael Montero Fernández, Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Antonio Alves de Melo Filho

May 2020

Comparative effect on liver fibrosis of bicyclol and silymarin

Bicyclol and silymarin are widely used in the treatment of various liver diseases; however, there is no report on comparative effect of them on liver fibrosis. To compare their liver protective effect, liver fibrosis rats induced by bile duct ligation (BDL) were orally treated with 100 mg/kg bicyclol and 100 mg/kg silymarin respectively for 4 weeks. Liver index, liver function activities, inflammatory biomarkers,...

Author(s): Liping Wang, Li Zhang, Kelan Gan, Xiaoping Hua, Ying Xiao, Yikun Shi and Zhenghuai Tan  

May 2020

Designing polyethylene oxide and hydroxypropyl methylcellulose matrix tablets with comparable dissolution properties

PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. Based on the dissolution results obtained using Apparatus 3, a 53% concentration of PEO polymer in the...

Author(s): Petra Draksler, and Biljana Janković,  

May 2020

The potential cardioprotective effects of Febuxostat versus Cilostazol on Isoproterenol induced cardiac dysfunction in rats

Myocardial infarction causes an acute condition of necrosis of the myocardium resulting in increased production of free radicals and decreased levels of antioxidants. It was proposed that Febuxostat reduced myocardial oxidative stress and suppressed apoptosis. Cilostazol used to treat claudication has a growing evidence, suggesting that Cilostazol could be cardioprotective. This work aims to highlight the potential...

Author(s): Ayman Helal, Sawsan Sadik and Eman Hussein