African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2199

Table of Content: September, 2020; 14(8)

September 2020

Development and validation of UV- Spectrophotometric and RP-HPLC method for the analysis of raw material and formulations of Aceclofenac

The purpose of the study is to develop and validate method for assay of Aceclofenac in tablet dosage forms using ultra violet spectrophotometry (UV) and high performance liquid chromatography (HPLC) techniques. A method was developed and validated for analysis of Aceclofenac using UV technique with methanol and phosphate buffer 7.4 as solvent. The HPLC analysis was conducted using two mobile phases, that is,...

Author(s): Tahir Jamshaid, Syed Saeed ul Hassan, Hammad Ahmed, and Muhammad Khalil ur Rehman

September 2020

Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

Cancer and microbial infectious diseases are considered a global threat. Plants have been investigated across the world to exploit their potential anticancer and antimicrobial effective agents. In this study, two medicinal plant species native to Saudi Arabia, namely; Artemisia judaica and Artemisia sieberi were screened to assess their antioxidant, anticancer and antimicrobial potential activities as well as...

Author(s): Fahd A. Nasr, Omar M. Noman, Ramzi A. Mothana, Ali S. Alqahtani and Abdullah A. Al-Mishari  

September 2020

Cardioprotective effects of animal grade piperazine citrate on isoproterenol induced myocardial infarction in wistar rats: Biochemical and histopathological evaluation

The present study was designed to investigate the cardioprotective effect of animal grade piperazine citrate on isoproterenol-induced myocardial infarction in rats by studying cardiac marker enzymes and histopathological changes of the cardiac muscle. Isoproterenol administration showed significant (P<0.001) increase in the serum levels of cardiac injury markers (creatine kinase-MB and troponin-I), 358.98 ±...

Author(s): Ghasi, S. I., Umana, I. K., Ogbonna, A. O., Nwokike, M. O. and Ufelle, S.  

September 2020

Assessment of anti-hepatitis B virus activity of endemic medicinal plants from Socotra Island

Hepatitis B virus (HBV) is a leading cause of liver disease and a possible worldwide source of severe morbidity and mortality. The current standard therapy using interferons or antiviral agents is not successful in all cases and is associated with severe side effects. Consequently, the development of new medicines for the treatment of HBV is still relevant. This experimental study was therefore performed to assess the...

Author(s): Ramzi A. Mothana, Ahmed H. Arbab, Mohammad K. Parvez and Mohammed S. Al-Dosari  

September 2020

Neuroprotective effects of methanol extract of Terminalia macroptera leaf in mice

The plant Terminalia macroptera has been reported to possess many pharmacological activities. The aim of the present study was to screen the effect of the methanol extract of T. macroptera against ketamine-induced mice model of psychosis and the apomorphine climbing test. The behavioural studies entailed an evaluation of locomotor activity, stereotypic behaviours in the open field and stereotypic climbing behaviour,...

Author(s): Lydia Doosuur Ior, Sunday Oritsetimenyin Otimenyin and John Stephen Gushit  

September 2020

Investigation of hemotoxicologic potential of an ayurvedic preparation “Kutajarista” used in Sprue syndrome after chronic administration to male Sprague-Dawley rats

The ayurvedic medicinal system is the world’s most primitive medical systems which were originated in India. For the treatment of Sprue syndrome, a very well-known ayurvedic preparation named Kutajarista (KTJ) is used in the south Asian region. This study aimed to detect the impact of chronic administration of KTJ on hematological parameters. The experimental animals were subdivided into two groups. A high dose...

Author(s): Mohammad Tohidul Amin, Kaniz Fatema, Palash karmakar, Md. Abdur Rahman, Tazmel Haque and M. Shahabuddin Kabir Choudhuri  

September 2020

Hepatoprotective and free radical scavenging activities of methanol extract fractions of Capparis decidua Edgew (Forssk.) (Capparidaceae)

The main objective of the study is to evaluate the hepatoprotective and antioxidant activities of different extracts and fractions of a Sudanese traditionally used plant, Capparis decidua Edgwe (Forssk.) (Capparidaceae). Carbon tetrachloride (CCl4) induced hepatotoxicity in rats, and DPPH radical scavenging activity (RSA) were the methods used to evaluate the hepatoprotective and antioxidant activities of this plant...

Author(s): Mohamed Mirghani, Hassan S. Khalid, Mona S. Mohammed, Ahmed Babiker Mohamed, Amna Ali, Wadah Osman, Waleed A Alobaid and Ramzi A. Mothana  

September 2020

Assessment of the antioxidant and antimicrobial activities of Caralluma deflersiana growing in the South of Saudi Arabia

Reactive oxygen species and oxidative stress are related to a large number of human degenerative diseases. Consequently, plants have been investigated across the world to exploit their potential antioxidant and antimicrobial activities. In the current study, Caralluma deflersiana is native to Saudi Arabia and was screened to assess its antioxidant and antimicrobial potential activities as well as the phenolic...

Author(s): Mona Nasser BinMowyna and Muneer Mohammed Alsayadi