African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2198

Full Length Research Paper

Investigation of hemotoxicologic potential of an ayurvedic preparation “Kutajarista” used in Sprue syndrome after chronic administration to male Sprague-Dawley rats

Mohammad Tohidul Amin
  • Mohammad Tohidul Amin
  • Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
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Kaniz Fatema
  • Kaniz Fatema
  • Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhlai-3814, Bangladesh.
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Palash karmakar
  • Palash karmakar
  • Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
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Md. Abdur Rahman
  • Md. Abdur Rahman
  • Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
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Tazmel Haque
  • Tazmel Haque
  • Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh.
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M. Shahabuddin Kabir Choudhuri
  • M. Shahabuddin Kabir Choudhuri
  • Department of Pharmacy, Faculty of Biological Science, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
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  •  Received: 02 July 2020
  •  Accepted: 24 July 2020
  •  Published: 30 September 2020

Abstract

The ayurvedic medicinal system is the world’s most primitive medical systems which were originated in India. For the treatment of Sprue syndrome, a very well-known ayurvedic preparation named Kutajarista (KTJ) is used in the south Asian region. This study aimed to detect the impact of chronic administration of KTJ on hematological parameters. The experimental animals were subdivided into two groups. A high dose (50 mL/kg) of body weight was given to the first group for 42 days and the second group which was considered as the control group was treated with normal water for the same period. There was a remarkable reduction [10.37%, p=0.092] in the total numbers of red blood cells (RBC). A prominent decrease [10.75%. p=0.097] is also observed in the hemoglobin content of the blood. There was a noticeable [11.05%, p=0.077] decrease in the hematocrit level of the blood and a very high [64.35%, p=0.19] increase in the number of white blood cell (WBC) count of the male Sprague-Dawley rat. A remarkably high increase was observed in the absolute count of Neutrophils (220.161%, p=0.12), Eosinophils (368.75%, p=0.11), Lymphocytes [11.29%, p=0.06], and Monocyte [142.781%, p=0.13] count. Also a prominent [↑ 14.15%, p=0.42] increase in the number of platelet counts was observed. Rat cutaneous tail bleeding time and whole blood clotting time shortening were also observed and the result is statistically prominent. As the result shows a significant change in different hematological parameter it can be summarized that KTJ have potential hemotoxicity at a higher dose. Further study is required at a lower dose.

Key words: Ayurvedic, Kutajarista, hemotoxicity, red blood cells (RBC), white blood cells (WBC).