African Journal of
Plant Science

  • Abbreviation: Afr. J. Plant Sci.
  • Language: English
  • ISSN: 1996-0824
  • DOI: 10.5897/AJPS
  • Start Year: 2007
  • Published Articles: 805

Full Length Research Paper

Neuroprotective effect of Khaya grandifoliola against aluminium chloride (AlCl3) induced neurotoxicity in rats

Domkem Nkameni Léa
  • Domkem Nkameni Léa
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Owona Ayissi Brice
  • Owona Ayissi Brice
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Ambassa Axel Cyriaque
  • Ambassa Axel Cyriaque
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Njingou Ibrahim
  • Njingou Ibrahim
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Ngoungoure Ndam Viviane Laure
  • Ngoungoure Ndam Viviane Laure
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Njayou Frédéric Nico
  • Njayou Frédéric Nico
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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Moundipa Fewou Paul
  • Moundipa Fewou Paul
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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  •  Received: 16 February 2024
  •  Accepted: 17 April 2024
  •  Published: 30 April 2024

Abstract

Aluminium chloride (AICl3) is known as a potent environmental neurotoxin causing progressive neurodegeneration in the brain. Khaya grandifoliola (KG) is used in Cameroon in traditional medicine for its therapeutical properties. Thus, the aim of this study was to evaluate the neuroprotective effect of K. grandifoliola against AICl3-induced neurotoxicity in rats. The KG25-fraction was obtained by maceration of the K. grandifoliola bark powder followed by fractionation by flash chromatography. The neuronal dysfunction induced by AICl3 was evaluated on 36 rats divided into 6 groups of 6 rats each during 45 days. On day 46 after 24 h of fasting, the rats were sacrificed. AST, ALT, PAL, catalase activity, glutathione level, peroxidized lipid level and acetylcholinesterase activity were assessed. AICl3-induced anxiety was reduced by administration of the K. grandifoliola 25-fraction. The oxidative stress response of the K. grandifoliola 25 fraction showed a significant increase (p<0.05) in catalase activity at the dose of 225 mg/kg body weight, glutathione and lipid peroxidation levels followed the same pattern. Acetylcholinesterase activity showed a significant increase in group III (positive control) and a significant decrease (p<0.05) in the experimental groups. The K. grandifoliola 25 fraction effectively protects the brain of rats against the toxic effects of AICl3 at doses (75 and 225 mg/kg) body weight, respectively.

 

Key words: K. grandifoliola 25, AICl3, anxiety, neurotoxicity, oxidative stress.