African Journal of
Plant Science

  • Abbreviation: Afr. J. Plant Sci.
  • Language: English
  • ISSN: 1996-0824
  • DOI: 10.5897/AJPS
  • Start Year: 2007
  • Published Articles: 805

Full Length Research Paper

Neuroprotective effect of Khaya grandifoliola against aluminium chloride (AlCl3) induced neurotoxicity in rats

Domkem Nkameni Léa
  • Domkem Nkameni Léa
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Owona Ayissi Brice
  • Owona Ayissi Brice
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Ambassa Axel Cyriaque
  • Ambassa Axel Cyriaque
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Njingou Ibrahim
  • Njingou Ibrahim
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Ngoungoure Ndam Viviane Laure
  • Ngoungoure Ndam Viviane Laure
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Njayou Frédéric Nico
  • Njayou Frédéric Nico
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
  • Google Scholar
Moundipa Fewou Paul
  • Moundipa Fewou Paul
  • Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon.
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  •  Received: 16 February 2024
  •  Accepted: 17 April 2024
  •  Published: 30 April 2024

References

Adebayo AB, Samuel AO, Joseph OH, Sunday SA (2012). Effect of aluminum chloride exposure on the histology of the liver of adult Wistar rats. Journal of Pharmacy 2:525-533.
Crossref

 

Amjad S, Umesalma S (2015). Protective effect of Centella asiatica against aluminium-induced neurotoxicity in cerebral cortex, striatum, hypothalamus and hippocampus of rat brain-histopathological, and biochemical approach. Journal of Molecular Biomarkers & Diagnosis 6(1).
Crossref

 

Amougou AM (2012). Propriété antiacétylcholinestérase des extraits de Khaya grandifoliola C.D.C et d'EntadaafricanaGuill et Perr. Mémoire de Master Biochimie, Université de Yaoundé I, Cameroun pp. 31-41.

 

Bickii J, Njifutie N, Foyere JA, Basco LK, Ringwald P (2000). In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). Journal of Ethnopharmacology 69:27-33.
Crossref

 

Brice AO, Frederic NN, Pierre M, Paul FM (2022). Khaya grandifoliola active fraction as source of therapeutic compounds for Alzheimr's disease treatment: In silico validation of identified compounds. In Silico Pharmacology 10:11.
Crossref

 

Chia-Yi Y, Yih-Jing L, Guoo-Shyng WH (2012). Aluminium overload increases oxidative stress in four functional brain areas of neonatal rats. Journal of Biomedical Sciences 19(1):51.
Crossref

 

Costa P, Goncalves S, Andrade PB, Valentao P, Romano A (2011). inhibitory effect of Lavanda viridis on Fe2+-induced lipid peroxidation, antioxidant anticholinesterase properties. Food Chemistry 126:1779-1786.
Crossref

 

Claiborne A (1985). Catalase activity. In: Greenwald, RA, Ed., CRC Handbook of Methods for Oxygen Radical Research, CRC Press, Boca Raton pp. 283-284.

 

Dey M, Singh RK (2022). Chronic oral exposure of alumunium chloride in rat modulates molecular and functional neurotoxic markers relavant to alzheimer's disease. Pub Med 32(5):616-627.
Crossref

 

Ferri CP, Prince P, Brayne C (2005). Global prevalence of dementia: A delphi consensus study. Lancet Neurology 366:2112-2117.
Crossref

 

Fils AE, Simon NF, Mario RDK, Pascal O, Frederic NN, Paul FM (2022). Khaya grandifoliola Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats. American Journal of Biomedical and Life Sciences 10(3):84-96.
Crossref

 

Galani BRT, Sahuc ME, Sass G, Njayou FN, Loscher C, Nkounga P, Deloison G, Brodin P, Rouilllé Y, Tiegs G, Séron K, Moundipa FP (2016). Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. Archives of Virology 161:1169-1181.
Crossref

 

Galani TBR (2009). Essai d'isolement des hépatocytes de rat et application à l'étude des propriétés antihépatotoxiques de trois plantes médicinales. DEA de Biochimie. Université de Yaoundé 1, Cameroun pp. 39-46.

 

Gentsch C, Lichtsteiner M, Feer H (1987). Open Field and Elevated Plus-Maze: A Behavioural Comparison between Spontaneously Hypertensive (SHR) and Wistar-Kyoto (WKY) Rats and the Effectq of Clordiazepoxide. Behavioural Brain Research 25:101-107.
Crossref

 

Kaumar V, Gill KP (2014). Oxidative and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review. Neurotoxicology 41:154-166.
Crossref

 

Lakshmi BV, Sudhakar M, Prakash KS (2015). Protective effect of selenium against aluminium chloride-induced Alzheimer's disease: behavioral and biochemical alterations in rats. Biological Trace Element Research 165(1):67-74.
Crossref

 

Mahalakshmi CND, Prathyusha D, Madhavic T, Swathi G, Sushma NJ (2015). Antioxidant Role of Ceitoria ternatea extract against Aluminium-induced Oxidative Stress in Hippocampus of albino Rats. International Journal of Scientific and Engineering Research 6:156-160.

 

Moundipa PF, Njayou FN, Yantitoum S, Sonke B, Tchouanguep FM (2002). Medical plants used in the Bamoun region of the western province of Cameroon against jaundice and other liver disorders. Cameroonian Journal of Biological and Biochemical Sciences 12(2):39-46.

 

Mukaila YO, Ajao AAN, Moteetee AN (2021). Khaya grandifoliola C. DC. (Meliaceae: sapindales): ethnobotany, phytochemistry, pharmacological properties, and toxicology. Journal of Ethnopharmacology 278:114253.
Crossref

 

Njayou FN, Aboudi ECE, Tandjang MK, Tchana AK, Ngadjui BT, Moundipa PF (2013). Hepatoprotective and antioxidant activities of stem bark extract of Khaya grandifoliola (Welw) CDC and Entada africana Guill. et Perr. Journal of Natural Products 6(1):73-80.

 

Njayou FN, Kouam AF, Simo BFN, Tchana AN, Moundipa PF (2016). Active chemical fractions of stem bark extract of Khaya grandifoliola C.DC and Entada africana Guill. et Perr. synergistically protect primary rat hepatocytes against paracetamol-induced damage. BMC complementary and alternative medicine 16:1-11.
Crossref

 

Ohkawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxydes in animal tissues by thiobarbituric acid reaction. Anal Biochemistry 95(2):351-358.
Crossref

 

Olowokudejo JD, Kadiri AB, Travih VA (2008). An ethnobotanical survey of herbal markets and medicinal plants in Lagos state of Nigeria. International Journal of Ethnobotanical Research 12:851-865.

 

Pellow S, Chopin P, File SE, Briley M (1985). Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14(3):149-167.
Crossref

 

Prakash A, Kumar A (2013). Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism. Neurological Sciences 34:1403-1409.
Crossref

 

Sung MN, Dae YY, Hyun JK, Jong WK, Hyo YJ, Dae WK, Je KS, In KH, Yeo SY (2019). Effects of long-term exposure to aluminium in the hippocampus in the type 2 diabetes model rats. Toxicology Research 8(2):206-2015.
Crossref

 

Talita HFV, Isabella MG, Flavia RV, Fabiola MR (2016). Alzheimer's disease: targeting the cholinergic system. Current neuropharmacology 14(1):101-115.
Crossref

 

Taus N, Faraj M, Tanase S, Méronescu A, Biocu M, Neculas V, Taus L (2013). Aluminium-A chemical neurotoxic agent: Bulletin of the transilvania University of Brasov Series VI: Medical Sciences 6(55):1-8.

 

Thangarajan S, Chandrasekar S, Varadharajan M, Ramachandran S, Manogaran S, Arunachalam V, Krishnamoorthi R (2013). Oxidative stress in brains of male rats intoxicated with aluminium and neuromodulating effect of celastrus paniculatus alcoholic seed extract. Asian Journal of Pharmaceutical and Clinical Reseach 6:80-90.

 

Teugueu CK, Nguefack S, Doumbe J, Fogang YF, Mbonda PC, Mbonda E (2013). The spectrum of neurological disorders presenting ataneurological clinic in Yaounde, Cameroon. The Pan African Medical Journal 14:34-39.
Crossref

 

Wang L, Benzinger TL, Su Y, Christensen J, Friedrichsen KAP (2016). Evaluation of tau imaging in staging Alzheimer disease and revealing interactions between β-amyloid and tauopathy. JAMA Neurology 73:1070-1077.
Crossref

 

Wróblewski F, Ladue JS (1956). Serum glutamic pyruvic transaminase (SGP-T) in hepatic disease: a preliminary report. Annals of Internal Medicine 45(5):801-811.
Crossref