African Journal of
Plant Science

  • Abbreviation: Afr. J. Plant Sci.
  • Language: English
  • ISSN: 1996-0824
  • DOI: 10.5897/AJPS
  • Start Year: 2007
  • Published Articles: 808

Full Length Research Paper

Hepatoprotective and hepatocurative properties of alcoholic extract of Carthamus oxyacantha seeds

Ellahi Bukhsh
  • Ellahi Bukhsh
  • Department of Biochemistry, Faculty of Biological sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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Salman Akber Malik
  • Salman Akber Malik
  • Department of Biochemistry, Faculty of Biological sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  • Google Scholar
Sheikh Saeed Ahmad
  • Sheikh Saeed Ahmad
  • Department of Environmental Sciences, Fatima Jinnah Women University, Rawalpindi, Pakistan.
  • Google Scholar
Summra Erum
  • Summra Erum
  • Department of Environmental Sciences, Fatima Jinnah Women University, Rawalpindi, Pakistan.
  • Google Scholar


  •  Received: 15 March 2012
  •  Accepted: 25 May 2012
  •  Published: 31 January 2014

References

Afaf I, Abuelgasim, Nuha HS, Mohammed AH (2008). Hepato-protective effect of Lepidium sativum against car-bontetrachloride-induced damage in rats. Res. J. Anim. Vet. Sci. 3:20-23.
 
Arulkumaran KS, Rajasekaran A, Ramasamy A, Jegadee-san M, Kavimani S, Somasundaram A (2009). Cassia rox-burghii seeds protect liver against toxic effects of ethanol and carbontetrachloride in rats. Int. J. Pharm-Tech. Res. 1(2):273-246.
 
Borba EL, Trigo JR, Semir J (2001). Variation of diastereoisomeric pyrrolizidine alkaloids in Pleurothallis (Orchidaceae). Biochem. Syst. Ecol. 29:45-52.
Crossref
 
Desjardins JP, Iversen PL (1995). Inhibition of the rat cytochrome, P450 3A2 by an antisense photo-orothioate oligodeoxy nucleotide in vivo. J. Pharmacol. Exp. Ther. 275:1608-1613.
 
Gopinathan N, Srinivasan KK, Mathew JE (2004). Free radical scavenging properties of ethanol extract of Saccharum spontaneum. Indian Drugs. 41:633-635.
 
Halim AB, Ahmady OE, Hassab-Allah S, Abdel-Jalil F, Hafez A, Darwish A (1997). Biochemical effects of antioxidants on lipids and liver function in experimentally induced liver damage. Ann. Clin. Biochem. 34:656-663.
Crossref
 
Hui-Mei L, Hsien-Chun T, Chau-Jong W, Jin-Jin L, Chia-Wen L, Fen-Pi C (2008). Hepatoprotective effects of Sola-num nigrum Linn extract against CCl4-iduced oxidative damage in rats. Chem-Biol. Interact. 171:283-293.
Crossref
 
Mattocks AR, Jukes R (1990). Trapping and measurement of short-level alkylating agents in a recirculating flow system. Chem-Biol. Interact. 76:19-30.
Crossref
 
Nelson D, Kamataki T, Waxman D, Guengerrich P, Estabrook R, Feyerisen R, Gozalcz F, Coon M, Gunsahts I, Cotoh O, Okuda K, Nebert D (1993). The P450 Superfamily: update on new sequences, gene mapping, expression numbers, Early trivial names of enzymes and nomenclature, DNA. Cell. Biol. 12:1-51.
Crossref
 
Osol A (1975). Extraction and Extractives. Remington's Pharma Material Sciences. Mack Publishing. Co. Easton, Pennsylvania, U.S.A. Reprinted by National Book Foundation of Pakistan. 15:1509.
 
Parra JL, Reddy KR (2003). Hepatotoxicity of hypolipidemic drugs. Clinic Liver Dis. 7(2):415-433.
Crossref
 
Ravikumar V, Shivashangari KS, Devaki T (2005). Hepatoprotective activity of Tridax procumbens against d-galactosamine/lipopolysaccharide-induced hepatitis in rats. J. Ethnopharmacol. 101:55-60.
Crossref
 
Reinke LA, Lai EK, DuBose CM, McCay PB (1987). Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proc. Natl. Acad. Sci. 84:9223-9227.
Crossref
 
Roger D, Pamplona R (2001). Liver toxicity Encyclopedia of Medicinal plants. 392-395.
 
Sahu SC, Sapienza PP, Sprando RL, Collins TFX, Ross IA, Flynn TJ, Wiesenfeld PL, Donnell MWO, Kim CS (2005). Hepatotoxicity of androstenedione in pregnant rats, Food Chem. Toxicol. 43: 341-344.
Crossref
 
Sallie R, Tredger JM, William R (1991). Drugs and the liver. Biopharm. Drug Dispos. 12:251-259.
Crossref
 
San Feliciana A, Barrero AF, Miguel del Corral JM, Gacimartin MV, Medarde M (1982). Phytochemistry 21:2115-2117.
Crossref
 
Sanmugapriya E, Venkataraman S (2006). Studies on the hepatoprotective and antioxidant actions of Strychnos potatorum Linn seeds on CCl4 - induced hepatic acute injury in experimental rats. J. Ethnopharmacol. 105:154-160.
Crossref
 
Shibayama Y (1989). Endotoxaemia and hepatic injury in obstructive jaundice. J. Pathol. 159:335-339.
Crossref
 
Shin KH (1989). Hepatic drug metabolising enzyme inhibitors from herbal medicines. Proc, 2nd. Int. symp. Rcce. Adv. Nat. Prod. Res. pp. 176-195.
 
Slater TF, Cheeseman KH, Davies MJ, Proudfoot K, Xin W (1987). Free radical mechanisms in relation to tissue injury. Proc. Nutr. Soc. 46:1-12.
Crossref
 
Smialowicz RRJ, Simmon JE, Luebke RW, Allis JW (1991). Immunotoxicologic assessment of subacute exposure of rats to carbon tetrachloride with comparison to hepatotoxicity and nephrrotoxicity. Fundam. Appl. Toxicol. 17:186-196.
Crossref
 
Stickel F, Schuppan D (2007). Herbal medicine in the treatment of liver diseases. Digestive Liver Disease. 39:293-304.
Crossref
 
Stierum R, Heijne W, Kienhuis A, van Ommen B, Groten J (2005). Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals. Toxicol. Appl. Pharmacol. 207(2 Suppl):179-188.
Crossref
 
Vadiraja BB, Gaikwad NW, Madyastha KM (1998). Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats. Biochem. Biophys. Res. Commun. 249(2):428-431.
Crossref
 
Van de Straat R, de Vries J, Dcbcts AJJ, Vermiculein NPE (1987). The mechanism of paracetamol induced hepatotoxicity by 3,5-diaIkyl substitution; the role of glutathione depletion and oxidative stress. Biochem. Pharm. 36:2065-2071.
Crossref