Biotechnology and Molecular Biology Reviews

  • Abbreviation: Biotechnol. Mol. Biol. Rev.
  • Language: English
  • ISSN: 1538-2273
  • DOI: 10.5897/BMBR
  • Start Year: 2006
  • Published Articles: 102


Kojic acid: Applications and development of fermentation process for production

Rosfarizan Mohamad1, Mohd Shamzi Mohamed1, Nurashikin Suhaili1,Madihah Mohd Salleh 2 and Arbakariya B. Ariff 1*
1Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. 2Faculty of Bioscience and Bioengineering, Universiti Teknologi Malaysia, Skudai, 81310 Johor, Malaysia.
Email: [email protected]

  •  Accepted: 16 March 2010
  •  Published: 30 April 2010


Kojic acid, 5-hydroxy-2-hydroxymethyl-g-pyrone, has many potential industrial applications. In this review, the properties and diverse applications of kojic acid in industries are described. The review also discusses the advance in kojic acid fermentation, focusing on the process development in micro-organisms and strain selection, medium and culture optimization, as well as fermentation modes for commercially viable industrial scale production. The performances of various fermentation techniques that have been applied for the production of kojic acid are compared, while the advantages and disadvantages of each technique are discussed in this paper.


Key words: Kojic acid, mild antibiotic, anti-browning agent, tyrosinase inhibitor, submerged fermentation, resuspended cell system, surface culture.