International Journal of
Genetics and Molecular Biology

  • Abbreviation: Int. J. Genet. Mol. Biol.
  • Language: English
  • ISSN: 2006-9863
  • DOI: 10.5897/IJGMB
  • Start Year: 2009
  • Published Articles: 134

Full Length Research Paper

Contribution of cytogenetic and molecular biology in disorders of sex development diagnosis: About 55 cases

Fatou Diop GUEYE
  • Fatou Diop GUEYE
  • Doctoral School of Life, Health and Environmental Sciences, ED-SEV, Biology and Human Pathologies, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Fatimatou DIA
  • Fatimatou DIA
  • Laboratory of Clinical Cytology-Cytogenetic-Biology of Reproduction and Human Development, Cytogenetic Unit, Aristide Le Dantec Hospital, Dakar, Senegal.
  • Google Scholar
Arame NDIAYE
  • Arame NDIAYE
  • Laboratory of Clinical Cytology-Cytogenetic-Biology of Reproduction and Human Development, Cytogenetic Unit, Aristide Le Dantec Hospital, Dakar, Senegal.
  • Google Scholar
Adji Dieynaba DIALLO
  • Adji Dieynaba DIALLO
  • Doctoral School of Life, Health and Environmental Sciences, ED-SEV, Biology and Human Pathologies, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Mame Venus GUEYE
  • Mame Venus GUEYE
  • Department of Biology and Functional Explorations, Histology-Embryology Laboratory, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Ndiaga Diop
  • Ndiaga Diop
  • Department of Biology and Functional Explorations, Histology-Embryology Laboratory, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Mama SY DIALLO
  • Mama SY DIALLO
  • Department of Biology and Functional Explorations, Histology-Embryology Laboratory, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Oumar FAYE
  • Oumar FAYE
  • Department of Biology and Functional Explorations, Histology-Embryology Laboratory, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar


  •  Received: 21 November 2022
  •  Accepted: 13 January 2023
  •  Published: 31 January 2023

References

Al Jurayyan NA (2011). Medical Sciences. Malaysian Journal of Medical Sciences 3(18):4-12.

 

Artois M, Salmon D (2009). Détermination expérimentale du sexe et de l'âge chez le renard roux (Vulpes vulpes): Validité et reproductibilité des techniques choisies?: Mammalia. Mammalia 45(3).
Crossref

 

Azonbakin, S., Axede, B., Avakoudjo, J., Sissoko, S., Ouedraogo, A., Adjagba, M., Alao, M., Darboux, R., & Laleye A (2016). Anomalie du développement sexuel (DSD, 46 XY) par déficit en 17 β-Hydroxysteroïde deshydrogenase de type 3: Aspects clinique et biologique. Journal de La Société de Biologie Clinique Du Bénin 25:70-73.

 

Barbaux S, Vilain E, McElreavey K, Fellous M (1995). Update on sex determinism in mammals. MS. medicine science 11(4):529-536.
Crossref

 

Bashamboo A, Ledig S, Wieacker P, Achermann JC, McElreavey K (2010). New Technologies for the Identification of Novel Genetic Markers of Disorders of Sex Development (DSD). Sexual Development 4(4-5):213-224.
Crossref

 

Creighton S, Minto C (2001). Managing intersex. BMJ?: British Medical Journal, 323(7324):1264-1265.
Crossref

 

Dia F (2015). Contribution de cytogénétique au diagnostic de la différenciation sexuelle et des aneuploïdies à l'hôpital Aristide le Dantec (Mémoire de Master En Biologie Animale 238 :47). Université Cheikh Anta Diop de Dakar.

 

Diakité M L, Berthé H JG, Timbely A, Diallo M, Maiga M, Diakité A, Diallo M, Ouattara K, Faure A (2013). Problématique de la prise en charge des anomalies de la différenciation sexuelle dans le service d'urologie: CHU Point G. Progrès en Urologie 23(1):66-72.
Crossref

 
 
 

DIOUF AW (2004). [These doctorat en Médecine, Cheikh Anta Diop Dakar].

View

 

Ediati A, Juniarto AZ, Birnie E, Drop SLS, Faradz SMH, Dessens AB (2015). Body Image and Sexuality in Indonesian Adults with a Disorder of Sex Development (DSD). The Journal of Sex Research 52(1):15-29.
Crossref

 

Ediati A, Juniarto AZ, Birnie E, Okkerse J, Wisniewski A, Drop S, Faradz SMH, Dessens A (2017). Social stigmatisation in late identified patients with disorders of sex development in Indonesia. BMJ Paediatrics Open 1(1):e000130.
Crossref

 

Faye O, Azza S, Adil B, Doudou D, Berthé MA, Ndiaye M, Afoutou JM, Touré CT, Anthonioz P (2007). Diagnostic interest of Barr chromatin test in sex determination: About one case of male pseudohermaphrodism. Dakar Medical 52(3):204-208.

 

Folligan K, Laleye A, Moumouni H, Koffi KS, Yao GV, Adjagba M, James YE, Anoukoum T, Akakpo-Numado G, Hazemdji-Nimtche H, Defolo A (2012). Anomalie de developpement sexuel: Un cas de pseudohermaphrodisme masculin ou anomalie de developpement sexuel XY. Journal de La Recherche Scientifique de l'Universite de Lome 14(1):51-54.

 

Gao X, Chen G, Huang J, Bai Q, Zhao N, Shao M, Jiao L, Wei Y, Chang L, Li D, Yang L (2013). Clinical, cytogenetic, and molecular analysis with 46, XX male sex reversal syndrome: Case reports. Journal of Assisted Reproduction and Genetics 30(3):431-435.
Crossref

 

Goultaiene A, Elmortaji K, Sentissi R, Moataz A, Rabii R, Aboutaib R, Dakir M, Debbagh A, Meziane F (2016). Place de la laparoscopie dans la prise en charge des anomalies de différenciation sexuelle: À propos de 4 cas. Pan African Medical Journal 23(1).
Crossref

 

Gueniche K, Jacquot M, Thibaud E, Polak M (2008). L'identité sexuée en impasse…À propos de jeunes adultes au caryotypeXY nées avec une anomalie du développement des organes génitaux et élevées en fille. Neuropsychiatrie de l'Enfance et de l'Adolescence 56(6):377-385.
Crossref

 

Gueye MV, Faye O, Ndiaye A, Diop N, Diallo AS, Diallo MS (2014). Etude cytogénétique des anomalies chromosomiques par la chromatine de Barr et le caryotype au service d'histologie-embryologie-cytogénétique de Dakar: À propos de 100 cas. Journal de La Société de Bioloçgie Clinique Du Bénin 25:90-95.

 

Guillot V (2008). Intersexes: Ne pas avoir le droit de dire ce que l'on ne nous a pas dit que nous étions. Nouvelles Questions Féministes 27(1):37.
Crossref

 

Hersmus R, Stoop H, White SJ, Drop SL, Oosterhuis JW, Incrocci L, Wolffenbuttel KP, Looijenga LH (2012). Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. International Journal of Endocrinology pp. 1-9.
Crossref

 

Idrissi HK (2012, June 3). Hermaphodisme: Une anomalie congénitale très rare. L'Observateur du Maroc & d'Afrique | Hermaphrodisme.

View

 

Juniarto AZ, van der Zwan YG, Santosa A, Ariani MD, Eggers S, Hersmus R, Themmen AP, Bruggenwirth HT, Wolffenbuttel KP, Sinclair A, White SJ (2016). Hormonal evaluation in relation to phenotype and genotype in 286 patients with a disorder of sex development from Indonesia. Clinical Endocrinology 85(2):247-257.
Crossref

 

Kamiguchi Y, Tateno H, Mikamo K (1994). Chromosomally Abnormal Gametes as a Cause of Developmental and Congenital Anomalies in Humans. Congenital Anomalies 34(1):1-12.
Crossref

 

Kim KS, Kim J (2012a). Disorders of Sex Development. Korean Journal of Urology 53(1):1.
Crossref

 

Kossi EK (2003). Les ambiguités sexuelles en service de médecine interne de l'Hôpital National du Point G A propos de douze cas [Doctorat medecine, UNIVERSITÉDEB AMAKO Faculté de Médecine de Pharmacie et D'Odonto-Stomatologie].

View

 

Lee PA, Houk CP (2008). Disorders of Sexual Differentiation in the Adolescent. Annals of the New York Academy of Sciences 1135(1):67-75.
Crossref

 

Lee PA, Houk CP, Ahmed SF, Hughes IA, in collaboration with the participants in the International Consensus Conference on Intersex organized by the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology. (2006). Consensus Statement on Management of Intersex Disorders. PEDIATRICS, 118(2):e488-e500.
Crossref

 
 
 

Lin L, Philibert P, Ferraz-de-Souza B, Kelberman D, Homfray T, Albanese A, Molini V, Sebire NJ, Einaudi S, Conway GS, Hughes IA (2007). Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46, XY disorders of sex development with normal adrenal function. The Journal of Clinical Endocrinology and Metabolism 92(3):991-999.
Crossref

 

Lux A, Kropf S, Kleinemeier E, Jürgensen M, Thyen U (2009). Clinical evaluation study of the German network of disorders of sex development (DSD)/intersexuality: Study design, description of the study population, and data quality. BMC Public Health 9(1):1-7.
Crossref

 

MacLean HE, Warne G, Zajac JD (1997). Intersex disorders: Shedding light on male sexual differentiation beyond SRY. Clinical Molecular Endocrinology 46(1):101-108.
Crossref

 

Mastrandrea LD, Albini CH, Wynn RJ, Greenfield SP, Robinson LK, Mazur T (2012). Disorders of Sex Development: Management of Gender Assignment in a Preterm Infant with Intrauterine Growth Restriction. Case Reports in Medicine 1-4.
Crossref

 

Matejka M, Cribiu EP (1987). Idiogramme et représentation schématique des bandes G des chromosomes du mouton domestique (Ovis aries L.). Genetique, Selection, Evolution 19(1):113.
Crossref

 

Ndiaye M (2001). Ambigüités Sexuelles: Prise en Charge à Dakar These doctorat en Pharmacie, Cheikh Anta Diop Dakar.

View

 

Öçal G (2011). Current Concepts in Disorders of Sexual Development. Journel of Clinical Research in Pediatric Endocrinology 3(3):105-114.
Crossref

 

Pellestor F (2004). Âge maternel et anomalies chromosomiques dans les ovocytes humains. Médecine/sciences 20(6-7):691-696.
Crossref

 

Popescu CP (1975). L'étude du caryotype Bovin (Bos taurus) L.) par les méthodes de Bandes. Annales de Biologie Animale Biochimie Biophysique 4(15):751-756.
Crossref

 

Popescu CP, Hayes H, Dutrillaux B (2000). Techniques in animal cytogenetics. Springer-Verlag. http://prodinra.inra.fr/?locale=fr#!ConsultNotice:3224
Crossref

 

Poulat F, Goze C, Boizet B, Berta P (1992). Gene SRY et anomalies de la determination genetique du sexe chez l'homme. Andrologie 2(2): 50.
Crossref

 

Querfani B, El Mhef S, Rabii R, Joual A, Bennani S, Meziane F (2007). Hermaphrodisme vrai (à propos d'un cas). Journal Marocain d'Urologie 1(6):24-27.

 

R Development Core Team (2008). R: A Language and Environment for Statistical Computing. R foundation for statistical computing.

View

 

Settin A, Elsobky E, Hammad A, Al-Erany A (2008). Rapid Sex Determination Using PCR Technique Compared to Classic Cytogenetics. International Journal of Health Sciences 2(1):49-52.

 

Sultan C, Balaguer P, Terouanne B, Georget V, Paris F, Jeandel C, Lumbroso S, Nicolas JC (2001). Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation. Molecular and Cellular Endocrinology 178(1-2):99-105.
Crossref

 

Tijo JH, Levan A (1956). The chromosome number of man. Hereditas 42(1-2):1-6.
Crossref

 

Vekemans M (2003). Âge maternel et autres facteurs de risque de la trisomie 21. Annales de Biologie Clinique 61(4):497-499.

 

Wiesemann C, Ude-Koeller S, Sinnecker GHG, Thyen U (2010). Ethical principles and recommendations for the medical management of differences of sex development (DSD)/intersex in children and adolescents. European Journal of Pediatrics 169(6):671-679.
Crossref

 

Wu QY, Li N, Li WW, Li TF, Zhang C, Cui YX, Xia XY, Zhai JS (2014). Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive. BMC Urology 14(1):1-5.
Crossref