Background and objective: Plants have been used for the purpose curing, suppressing and prevention of some diseases by human being for many years. Arum dioscoridis is one of these plants. To evaluate its use in medicine, it is important to understand its toxicity on the animals. Thatâ€™s why, in this study toxicological effects of Arum dioscoridis extracts on Balb/c mice haematological and biochemical values were investigated.
Materials and methods: 30 growing Balb/c were used in this study. The animals divided into 5 groups of 6 animals per group were used. While the first group served as the control, the other 4 groups were seperated as the experiment groups. The control group received only water instead of extract. The crude arum extract, cooked arum extract, arum with yoghurt extract and cooked arum with yoghurt extracts were administered orally to the experimenal groups. The toxicity experiments were carried out for 3 days.
Results: After evaluating the results, statistically significant changes were found in some haematological parameters such as haemotocyte (HCT), mean corpuscular volume (MCV), lymphocyte (LYM) and white blood cells (WBC) parameters, but no changes were found on the other values. On the other hand, statistically significant differences were observed at the plasma level of aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma glutamic transferase (GGT) by the administration of A. dioscoridis extracts throughout the study.
Conclusion: The results showed that the crude arum extract had more toxicological effects on the Balb/c mice haematological and biochemical parameters than the others. Besides, the results showed that cooking and adding yoghurt into the arum mixture were useful ways for eliminating the toxic effects of Arum.
Keywords: Arum, extracts, toxicity, liver enzymes, yoghurt.