Journal of
AIDS and HIV Research

  • Abbreviation: J. AIDS HIV Res.
  • Language: English
  • ISSN: 2141-2359
  • DOI: 10.5897/JAHR
  • Start Year: 2009
  • Published Articles: 297

Short Communication

Polymorphism in the CC-chemokine receptor-5 (CCR5) gene and risk of AIDS among Kashmiri population

Syed Irtiza
  • Syed Irtiza
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Dil-Afroze
  • Dil-Afroze
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Niyaz A. Naykoo
  • Niyaz A. Naykoo
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Lateef Charoo
  • Lateef Charoo
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Iqbal Qasim
  • Iqbal Qasim
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Inayat S. Fazili
  • Inayat S. Fazili
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.Center of Animal Biotechnology,Sher-i-Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Shuhama (Alusteng), Srinagar, 190 006, India.
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Mir Aasif
  • Mir Aasif
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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Mushtaq A. Siddiqi
  • Mushtaq A. Siddiqi
  • Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir -190 011, India.
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  •  Accepted: 25 March 2011
  •  Published: 31 May 2011

Abstract

Chemokine receptors and their ligands may confer resistance to HIV-1 infection and/or AIDS progression. Our aim was to study our population for the most frequently studied polymorphism CCR5-Δ32 for evaluating their contribution to a protective genetic background against HIV infection and progression. One hundred and fifty blood samples from normal controls were recruited at random among prospective normal blood donors and forty blood samples of HIV/AIDS patients from Ethnic Kashmiri population were collected from Blood Bank and National AIDS Control Organisation of Sheri Kashmir Institute of Medical Sciences Soura, Kashmir respectively. Genotyping was performed by polymerase chain reaction (PCR) analysis followed by electrophoresis. The CCR5- Δ32 genotype frequency among our study group was wt/wt (93.3%), wt/mt (4%) and mt/mt (3%) from control group, revealing CCR5Δ32 allele frequency of 5%. The frequency of the CCR5- Δ32 allele among our study population seems to be remarkably higher compared to previously reported frequencies in other Asian populations. However, since this polymorphism is related with delayed progression from HIV infection to AIDS, it could be used for prognostic genotyping in HIV infected Kashmiri individuals.

 

Key words: CCR5- Δ32, HIV (Human immuno deficiency virus), mt (mutant type), wt (wild type).