Journal of
Microbiology and Antimicrobials

  • Abbreviation: J. Microbiol. Antimicrob.
  • Language: English
  • ISSN: 2141-2308
  • DOI: 10.5897/JMA
  • Start Year: 2009
  • Published Articles: 160

Full Length Research Paper

Prevalence and susceptibility to antibiotics of Neisseria gonorrhoeae strains isolated from genital samples in Bangui, Central African Republic

Christian Diamant Mossoro-Kpinde
  • Christian Diamant Mossoro-Kpinde
  • Laboratoire du Centre Hospitalier Maman Elisabeth Domitien, Bimbo, Central African Republic.
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Hermione Dahlia Mossoro-Kpinde
  • Hermione Dahlia Mossoro-Kpinde
  • Département de Santé Publique, Faculté des Sciences de la Santé, Université de Bangui, Bangui, Central African Republic.
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Fabrice Clavaire Assana
  • Fabrice Clavaire Assana
  • Direction du Centre National de Référence des Infections Sexuellement Transmissibles et de la Thérapie Antirétrovirale (CNRISTTAR), Bangui, Central African Republic.
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André Kouabosso
  • André Kouabosso
  • Direction du Centre National de Référence des Infections Sexuellement Transmissibles et de la Thérapie Antirétrovirale (CNRISTTAR), Bangui, Central African Republic.
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Alain Jean Michel Assana
  • Alain Jean Michel Assana
  • Sous-Bureau UNICEF de Bossangoa, Préfecture de l’Ouham, Central African Republic.
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Léon Kobangué
  • Léon Kobangué
  • Service de Dermatologie Vénérologie du Centre National Hospitalier Universitaire de Bangui, Bangui, Central African Republic.
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Gérard Grésenguet
  • Gérard Grésenguet
  • Département de Santé Publique, Faculté des Sciences de la Santé, Université de Bangui, Bangui, Central African Republic.
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  •  Received: 26 November 2021
  •  Accepted: 17 January 2022
  •  Published: 31 January 2022

Abstract

The frequency and antibiotic resistance of N. gonorrhoeae are increasing worldwide. This study aimed to determine the prevalence of N. gonorrhoeae in genital swabs. A collaborative cross-sectional study was conducted by a team of Microbiologist, Dermato-Venerologist and Occupational Physician in Bangui, from January 2015 to December 2018. Genital samples were stained by the Gram method, grown on blood agar and the colonies identified according to the biochemical characteristics. Antibiotic sensitivity was determined by the agar diffusion method from disks. The prevalence of N. gonorrhoeae was 3.2%,  more in males (90.5%), unschooled patients (61.1%),  those with a history of STIs (56.8%), and female sex workers (p = 0.006) The strains of N. gonorrhoeae isolated were highly resistant to all antibiotics commonly prescribed in proportions from 60.9 to 95.8%. No resistance was observed to Ceftriaxone and Spectinomycin. This study highlights the interest of intensifying the prevention of N. gonorrhoeae infection in female sex workers, of the revision of the protocols of management of the N. gonorrhoeae infection and of a policy to ensure a better availability of new antibiotics selected. Understanding the mechanisms of resistance will be the subject of a characterization study in molecular biology.

 

Key words: N. gonorrhoeae, STI, prevalence, antibiotic resistance, female sex workers, Central African Republic, Africa.