Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antimicrobial and antioxidant activities of essential oil and crude extracts of Hypericum tetrapterum Fries (Hypericaceae)

Aleksandra ĐorÄ‘ević1*, Andrija Šmelcerović2, Dragan Veličković3, Vesna Stankov-Jovanović1, Violeta Mitić1, Danijela Kostić1 and Radosav Palić1
1Department of Chemistry, Faculty of Science and Mathematics, University of Niš, 18000 Niš, Serbia. 2Department of Pharmacy, Faculty of Medicine, University of Niš, 18000 Niš, Serbia. 3College of Agriculture and Food Technology, 18400 Prokuplje, Serbia.
Email: [email protected]

  •  Accepted: 21 June 2010
  •  Published: 30 September 2013


In vitro antimicrobial activity of essential oil and crude extracts (petroleum ether, ethyl acetate and methanol extract) of Hypericum tetrapterum Fries (Hypericaceae) were investigated by disc diffusion and dilution methods. The studied samples were active against a panel of standardized bacteria and fungi. The maximum antimicrobial activity was shown by the essential oil and the petroleum ether extract. The antioxidant activity of the examined oil and extracts was determined by free radical scavenging assay and a phosphomolybdenum method. Both methods showed that the methanol crude extract of H. tetrapterumhad the highest antioxidant capacity among all samples investigated. The results of the pharmacological tests were discussed with respect to up to now known constituents of essential oil and crude extracts of H. tetrapterum. A correlation between the total flavonoid content and the antioxidant activity was observed. To the best of our knowledge this is the first report about the antimicrobial and antioxidant activities of the essential oil, crude petroleum ether and ethyl acetate extracts of H. tetrapterum.


Key words:  Hypericum tetrapterum Fries, Hypericaceae, antimicrobial activity, antioxidant activity, essential oil, crude extracts.